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Directory: Division of General and Gastrointestinal Surgery and Division of Colorectal Surgery (below)

Savita Khanna, Ph.D.


Staff photo

473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-7840

Email: khanna.15@osu.edu

 

Current OSU Appointment

Assistant Professor, Surgery

 

Academic Advising

I serve as a University appointed advisor for the Ohio State student’s band called Virtuoso, a band of OSU students, alumni and friends. Cultural development is a valuable component of student life. As a designated advisor, my responsibility is to make sure that these students abide my University rules and guidelines in utilizing facilities and conducting events. In addition, my responsibility is to be responsive to the needs of this group and secure necessary support from the University.

Biographical

Savita Khanna, PhD is an Assistant Professor of Surgery at the Ohio State University, Columbus Ohio. She received her PhD in 2000 in Physiology from University of Kuopio,Finland and completed her postdoctoral training at University of California, Berkeley and at The Ohio State University. Her research interests include the study of brain injury, neurodegeneration, nutrition and therapeutics. Her laboratory performs in vitro and in vivo studies related to mechanisms of neurodegeneration and interventional rescue. Dr. Khanna has over 95 peer-reviewed publications with an H-index of 43. She serves as the managing editor for the international peer-reviewed journal Antioxidants & Redox Signaling, which has an impact factor of 7.2, the highest ranking in the field. She has presented lectures at meetings and conferences both nationally and internationally. Dr. Khanna’s research is funded by National Institute Neurological Disorders & Stroke (NINDS), the American Heart Association (AHA), industry and the NIH-funded OSU Center for Clinical and Translational Science (CCTS) to investigate brain injury, repair, and the role of glutamate metabolism in stroke. In 2008, together with three other colleagues Dr. Khanna co-founded a University Technology Commercialization Company called NutrimiR LLC.

Noteworthy Graduate Narrative

Graduate student: Han-A Park. As a graduate student, Han-A won the awards and honors listed below. She is first and co-author on six publications till date. Currently, she is a post-doctoral fellow at a reputed neuroscience laboratory in Yale.



• 2011: 4th Annual Translational to Clinical (T2C) Wound Care Conference. Columbus. OH – First place poster

• 2010: 9th annual OSU Medical Center Research Day, Columbus, OH. - Travel Award



Graduate student: Jaideep Banerjee. As a graduate student, Jaideep won the awards and honors listed below. He is first and co-author on four publications till date. He is expected to graduate this fall.



• 2014: The Wound Healing Society of America award in Translational and Regenerative Science. Travel Award for Trainees

• 2012: The Wound Healing Society of America - Wound Biotechnology Foundation Travel Award for Trainees

• 2012: 26th Edward. F. Hayes Graduate Research Forum - Oral Presentation Award (3rd position)

• 2011: 4th Annual Translational to Clinical Research Meeting, USA - Best Poster award winner in the graduate student category

• 2011: 10th Allan Yates Memorial Lecture Series – Invited Speaker

• 2010, 2011: The Ohio State University Interdisciplinary Graduate Program –Molecular Life Sciences Annual Research Day – Best Poster Award

• 2010, 2011: The Ohio State University Medical Center Annual Research Day - Best Poster Award



Graduate Student: Amitava Das. As a graduate student, Amitava has won the awards and honors listed below. He is first and co-author on three publications till date.



• 2014: 13th Annual OSUWMC Trainee Research Day- Award for Poster Presentation

• 2014: Russel Klein Symposium conducted by OSUN - Award for Poster Presentation

• 2013: 5th Annual Translational to Clinical Research Meeting, USA - Best Poster Award - Graduate Student Category

• 2013: Russel Klein Symposium conducted by OSUN - Best Oral Presentation

• 2012 & 2013: Wound Healing Society – Young Investigator Award

• 2011: Russel Klein Symposium conducted by OSUN - Award for Poster Presentation

• 2011: OSU Department of Surgery Research Day – Best Poster Award

Advising Narrative

Undergraduate Student: Borna Reza Ghoorkhanian. As an undergraduate student, Reza was a co-author on one publication, which is listed below

.

• Khanna S, Rink C, Ghoorkhanian R, Gnyawali S, Heigel M, Wijesinghe DS, Chalfant CE, Chan YC, Banerjee J, Huang Y, Roy S, Sen CK.Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size. J Cereb Blood

Flow Metab. 2013 Aug;33(8): 1197-206.



I also mentor 4 other undergraduate students, Laura R. Caggiano, Robin Varghese, Lindsey J. Loss and Zachary C. Briggs, They have worked with me for less than six months.

Partnership Narrative

a

Postdoctoral / Researcher Advising

I meet with my post-doctoral researchers at least once a week for an hour to discuss their progress. If any issues have arisen during that week, we try to address them during that meeting and ensure that their work can continue as planned. The names of my postdoctoral researchers are listed below



• Mithun Sinha, PhD (2012-present)

• Ayan Biswas, PhD (2012-present)

• Subhadip Ghatak, PhD (2011-present)

• Kasturi Ganesh, MD (2009-present)

• Huang Yue, MD (2011-2012)

• Yuk Cheung Chan, PhD (2008-2012)

• Surya Gnyawali, PhD (2007-2010)

• Shani Goldberg-Shilo, PhD (2006-2009)



These postdoctoral students have many noteworthy accomplishments. Several of them have reached faculty status and have had very successful careers as researchers to date.

Master/Graduate Advising

I have mentored Jaideep Banerjee, a PhD student with the MCDB program since 2007. I have helped him design experiments, trained him in cell biology and molecular biology techniques. We have co-authored four publications where Jaideep has received technical advice from me. I also lead the lab journal club in which we discuss current literature and scientific advancements and Jaideep takes an active part in that. Jaideep will graduate this fall.



Since 2009 I am also directly involved in the training of Amitava Das, a graduate student in our lab, enrolled in the OSUN PhD program. Apart from instructing him in technical skills which involve cell culture, RNA isolation, cDNA preparation, RTPCR, genotyping and ELISA, I have also helped him to boost his critical thinking and writing skills which has helped him win several graduate student awards including the 2014 graduate student award from the College of Medicine. Amitava also benefits from the journal club that I lead.



It has been a privilege to mentor students, and I am very proud of all of their accomplishments. It is always a pleasure to watch them grow and learn as researchers, and it is very rewarding to be able to take part in improving their skills and expanding their opportunities as scientists.

Academic Advising

2007 - present Jaideep Banerjee The Ohio State University.
2009 - present Dr. Kasturi The Ohio State University.
2009 - present Amitava Das The Ohio State University.
2009 - present Ryan M. The Ohio State University. Graduated 2008.
2011 - present Dr. Subhadip The Ohio State University. Graduated 2012.
2011 - present Natasha Sinai The Ohio State University.
2011 - present Jessica Weist The Ohio State University. Graduated 2012.
2012 - present Dr. Ayan The Ohio State University. Graduated 2012.
2012 - present Dr. Mithun The Ohio State University. Graduated 2012.
2012 - present Laura R. The Ohio State University.
2013 - present The Ohio State University.
2014 - present Zachary C. The Ohio State University.
2014 - present Lindsey J. The Ohio State University.
2006 - 2008 Dr. Shani The Ohio State University.
2005 - 2010 Han-A Park The Ohio State University. Graduated 2010.
2007 - 2010 Dr. Surya The Ohio State University. Graduated 2007.
2009 - 2010 Natalia Kubicki The Ohio State University. Graduated 2012.
2010 - 2011 Borna Reza The Ohio State University. Graduated 2012.
2008 - 2012 Dr.Yuk Cheung The Ohio State University.
2010 - 2012 Sang Yong The Ohio State University.
2011 - 2012 Hunag Yue The Ohio State University.
2013 - 2014 Robin Varghese The Ohio State University.
 

Chapters in Books

Sen, C.K., Roy, S., Khanna, S., and Packer, L. "Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection."." In Methods Enzymol.. Vol. 299. 239-246. San Diego, CA, US|USA: Elsevier, January 1999.

Roy, S., Khanna, S., Bentley, K., Beffrey, P., and Sen CK.. "Functional genomics: high-density oligonucleotide arrays." In Methods Enzymol.. Vol. 353. 487-497. San Diego, CA, US|USA: Elsevier, January 2002.

Roy, S., Venojarvi, M., Khanna, S., and Sen, C.K.. "Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC coulometric electrode array." In Methods Enzymol.. Vol. 353. 326-332. San Diego, CT, US|USA: Elsevier, January 2002.

Khanna, S., Venojarvi, M., Roy, S., and Sen, C.K.. "Glutamate-induced c-Src activation in neuronal cells." In Methods Enzymol.. Vol. 352. 191-198. San Diego, CA, US|USA: Elsevier, January 2002.

S Roy, S Khanna and C.K. Sen.. "Perceived hyperoxia: oxygen-regulated signal transduction pathways in the heart." In Methods Enzymol. Vol. 381. 133-9. San Diego, CA, US|USA: Elsevier, February 2004.

W.A. Wallace, A. J. Cardounel, S Khanna, C.K. Sen. "Survival surgery for coronary occlusion and reoxygenation in a rodent model." In Methods Enzymol. Vol. 381. 175-184. San Diego, US|USA: Elsevier, January 2004.

A.K Tewari, S Roy, S Khanna, S, Sen C.K. "Proteomic analysis of the mammalian cell nucleus." In Methods Enzymol. Vol. 381. 192-201. San Diego, CA, US|USA: Elsevier, January 2004.

C.K. Sen, S Khanna, C Rink, S Roy.. "Tocotrienols: The Emerging Face of Natural Vitamin E." In Vitamin E. Vol. 76." In Vitamin E. Vol. 76. Edited by Gerald Witlack. -. San Diego: Academic Press, July 2007.

H Park, S Roy, S Khanna, C.K. Sen. "Current Technologies in Single Cell Microinjection and Application to Study Signal Transduction." In Method in Redox Signaling. Edited by Dipak K Das. -. New Rochelle: Mary Ann Liebert, Inc, September 2009.

M Atalay, D Larson, S Khanna, O Hänninen, C.K. Sen. "Oxidative stress induced by physical exercise." In Natural Antioxidants and Food Qualityin Atherosclerosis and cancer Prevention. Edited by J. T. Kumpulainen and J. T. Salonen. 36-40. [unspecified]: The Royal Society of Chemistry, January 2010.

D Larson, M Atalay, S Khanna, CK Sen. "Exercise and oxidative stress in diabetes mellitus." In Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention. Edited by J. T. Kumpulainen and J. T. Salonen. 22-26. [unspecified]: The Royal Society of Chemistry, January 2010.

C Rink, S Khanna, C.K. Sen. "Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-Tocotrienol as a Unique Therapeutic Agent." In Studies on experimental models. Edited by Samar Basu and Lars Wiklund. -. New York: Humana Prss, April 2011.

C Rink and S Khanna. "Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress." In Chronic Inflammation. Edited by Sashwati Roy , Debasis Bagchi , and Siba P . Raychaudhuri. -. Boca Raton: CRC Press, September 2012.

 

Conferences

Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., Packer, L., Hänninen, O., and Sen, C.K.. "Tissue glutathione homeostasis in response to lipoate supplementation and exercise." Oxygen Club of California, World Congress. (February 1997). Abstract # 132-.

Roy, S., Kobuchi, H., Sen, C.K., Gohil, K., Khanna, S., and Packer, L.. "Antioxidant properties and cell regulation." Oxygen Club of California, World Congress. (February 1998). Abstract # 52-.

Khanna, S., Sen, C.K., Roy, S., Christen, M. O., and Packer, L.. "Anethole dithiolethione (Sulfarlem) protects against oxidative stress induced cytotoxicity in human Jurkat T cells." Oxygen Club of California, World Congress. (February 1998). Abstract # 123-.

Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., Packer, L., Hänninen, O., and Sen, C.K.. "lipoate supplementation in exercise induced oxidative stress." Experimental Biology. (April 1998). Abstract # 6024-.

Gohil, K., Sen, C.K., Roy, S., Khanna, S., and Packer, L.. "Differential regulation of tumor necrosis factor –alpha induced expression by alpha-lipoate." Experimental Biology. (April 1998). Abstract # 1866-.

Vider, L., Atalay, M., Gul, M., Laaksonen, D. E., Khanna, S., Roy, S., Hänninen, O., and Sen, C.K.. "Effects of endurance training on tissue vitamin E and Ubiquinone levels." III International Congress of Pathophysiology. (June 1998). Abstract #118-.

Khanna, S., Roy, S., Reznick, A. Z., Packer, L., and Sen, C.K.. "TNF� induced NF-�B activation in skeletal muscle L6 cells is regulated by cell glutathione status." III International Congress of Pathophysiology. (June 1998). Abstract #116-.

Gul, M., Laaksonen, D. E., Atalay, M., Khanna, S., Vider, L., Roy, S., Hänninen, O., and Sen, C.K.. "Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rats." III International Congress of Pathophysiology. (June 1998). Abstract #115-.

Gohil, K., Roy, S., Khanna, S., Packer, L., and Sen, C.K.. "�-lipoic acid alters gene expression in human Jurkat T lymphocytes." III International Congress of Pathophysiology. (June 1998). Abstract #77-.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in L6 skeletal myotubes and the role of R-lipoic acid." Oxygen Club of California, World Congress. (March 1999). Abstract # 155-.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in L6 skeletal myotubes and the role of R-lipoic acid." American Society of Biochemistry and Molecular and Cellular Biology. (May 1999). Abstract # 1002-.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in skeletal muscle." 46th Annual Meeting of the American College of Sports Medicine. (June 1999). Abstract #1523-.

Atalay, M., Khanna, S., Laaksonen, D. E., Gul, M., Vider, L., Roy, S., Hänninen, O., and Sen, C.K.. "�-Lipoic acid supplementation in exercise." 46th Annual Meeting of the American College of Sports Medicine. (June 1999). Abstract #394-.

Sen,C,K; Khanna,S; Roy,S; Packer,L. "Vitamin E alpha-tocotrienol potently inhibits glutamate induced pp60c-Src kinase activation and death of HT4 neuronal cells." In FASEB JOURNAL. (March 2000). A554-A554.

Sen, C.K., Khanna, S., Roy, S., and Packer, L.. "Vitamin E Alpha tocotrienol potently inhibits glutamate induced pp60-Src kinase activation and death of HT4 neuronal cells." Experimental Biology. (April 2000). Abstract # 398.9-.

Sen, C.K., Khanna, S., Ryu. H., and Roy, S.. "Molecular basis of vitamin E neuroprotection." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #178-.

Roy, S., Khanna, S., Vider. J., and Sen, C.K.. "Redox control of wound angiogenesis." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #176-.

Khanna, S., Roy, S., Alessio, H., Bagchi, D., Bagchi, M., and Sen, C.K.. "Anti-angiogenic property of berry extracts." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #75-.

Sen,C,K; Khanna,S; Ellison,E,C; Hunt,T,K; Roy,S. "Redox control of wound repair." In FREE RADICAL BIOLOGY AND MEDICINE. (January 2002). S75-S76.

Khanna, S., Roy, S., Ryu, H., and Sen, C.K.. "Revisting the neuroprotective properties of vitamin E." Oxygen Club of California, World Congress. (March 2002). Abstract # 68-.

Sen, C.K., Khanna, S., Babior, B. M., Hunt, T.K., Ellison, E. C., and Roy, S.. "Redox control of wound repair." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 15-.

Roy, S., Khanna, S., Bickerstaff, A.A., Atalay, M., Bierl, M., Levy, D., Subramanian, S.V., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C.G., and Sen C.K.. "Oxygen sensitive signaling in the heart." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 20-.

Lappalainen, J., Atalay, M., Khanna, S., Roy, S., Nakao C., Oksala, N., Hanninen, O., and Sen C.K.. "Oxidative stress and heat shock proteins: protective role of physical exercise." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 50-.

Khanna, S., Roy, S., Ryu, H., Ratan R.R., and Sen, C.K.. "Molecular basis of vitamin E neuroprotection." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 49-.

Khanna, S., Roy, S., Chaki, S., and Sen, C.K.. "Tocotrienol: Nature’s Vitamin E for Neuroprotection?." Society for Neuroscience 34th Annual Meeting. (October 2004). .

Khanna, S. Slivka, A., Roy, S., Rink, C., Notestine, M. and Sen, C.K.. "Protective effects of oral �-tocotrienol in experimental stroke." 1st Mtg of the Japanese Society for Tocotrienol Research. (December 2004). .

Rink, C.L., Khanna, S.,Roy, S., Slivka, A., Craft, T.K.S.; Notestine, M., DeVries, C., and Sen, C.K.. "Natural vitamin E -tocotrienol protects against glutamate-induced neurodegeneration and stroke." Society for Neuroscience 35th Annual Meeting. (November 2005). .

Khanna, S., Roy, S., Maurer, M.R., Ratan.R.R., and Sen, C.K.. "Oxygen-sensitive reset of inducible hif transactivation response." Society for Neuroscience 35th Annual Meeting. (November 2005). .

Khanna, S., Ojha, N., Rink, C.L.S., Roy. S., and Sen, C. K.. "�-Tocotrienol: a potent form of natural vitamin E against stroke-related neurodegeneration." Society for Free Radical International XIII Congress. (August 2006). .

Khanna, S., Park, H., Rink, C.L.S., Roy, S. and Sen, C.K.. "Potent neuroprotection by the natural vitamin e α-tocotrienol: beyond antioxidant mechanisms." Society for Neuroscience 36th Annual Meeting. (October 2006). .

Rink, C.L.S., Khanna, S., Roy, S.; Park, H., Ghafourifar, P., and C.K.Sen. "The 12-lipoxygenase path of neurodegeneration: mitochondrial involvement and protection by the natural vitamin e α-tocotrienol." Society for Neuroscience 36th Annual Meeting. (October 2006). .

Roy, S., Khanna, S., and Sen, C.K.. "Fra2 mediates oxygen-induced tgfbeta-1 mrna expression in adult cardiac fibroblasts: significance in myocardial fibrosis following ischemia-reperfusion injury." American Heart Association. (November 2007). .

Rink, C.L.S., Khanna, S., Ojha, N., Roy, S., Radtke, J., and Sen, C.K.. "The oxygen-sensitive transcriptome in stroke-related injury of the brain: a therapeutic window of opportunity." Society for Neuroscience 37th Annual Meeting. (November 2007). .

Khanna, S., Roy, S., Park, H., and Sen, C.K.. "Regulation of c-src activity in glutamate-induced neurodegeneration." Society for Neuroscience 37th Annual Meeting. (November 2007). .

Rink, C. L., Christoforidis G. A., Kontzialis M., Bergdall V. K., Abduljalil, A., Roy, S., Khanna S., Knopp, M. V., and Sen, C. K.. "Novel pre-clinical model of acute ischemic stroke in canines: a minimally invasive neuroradiological approach of middle cerebral artery occlusion." Society for Neuroscience 38th Annual Meeting. (November 2008). .

Khanna, S., N. Parinandi., Roy, S., Rink., Park, H., and Sen, C.K.. "Tocotrienol protects mature cortical neurons against arachidonic acid-induced cell death through modulation of lipoxygenase." Society for Neuroscience 38th Annual Meeting. (November 2008). .

Khanna, S., Rink, C.L.S., Park, H., Roy, S., and Sen, C.K.. "Potent neuroprotection by the natural vitamin e α-tocotrienol: Beyond antioxidant mechanisms." International Conference on Free Radicals & Natural Products in Health and Seventh Annual Meeting of the Society of Free Radical Research India. (February 2008). .

Khanna, S., N. Parinandi, Kotha, S.R., Roy, S., C. Rink., Bibus, D., and Sen, C.K. "Arachidonic acid pathway as a key target for neuroprotection by nanomolar �-tocotrienol." Society for Neuroscience 39th Annual Meeting. (October 2009). .

Rink, C. L.,Roy, S., Khan, M., Ananth, P., Kuppusamy, P., Sen, C.K and Khanna, S.. "Characterization of the therapeutic potential for supplemental oxygen therapy in acute ischemic stroke." International Conference on Advances in Free Radicals & Natural Products, Antioxidants and Radioprotectors in Health and 9th Annual Meeting of the Society of Free Radical Research India. (January 2010). .

Khanna, S., N. Parinandi, Kotha, S.R., Roy, S., C. Rink., Bibus, D., and Sen, C.K. "Arachidonic acid pathway as a key target for neuroprotection by nanomolar �-tocotrienol." Annual meeting of the Oxygen Club of California. (February 2010). .

 

Degrees

1984 B.S., Meerut University

1986 M.S., Meerut University

1988 None Indicated, Meerut University

2000 Ph.D., University of Kuopio

 

Edited Books

Sen, Packer & Hanninen. "Handbook of Oxidants and Antioxidants in Exercise." Edited by Sen, Packer & Hanninen. Amsterdam: Elsevier Science Publishers, January 2000.

Chandan K Sen and Lester Packer. "Methods in Enzymology." Edited by Chandan K Sen and Lester Packer. San Diego: Academic Press, June 2002.

Chandan K Sen and Lester Packer. "Methods in Enzymology." Vol. 352. Edited by Chandan K Sen and Lester Packer. San Diego: Academic press, July 2002.

Chandan K. Sen and Gregg L. Semenza. "Methods in Enzymolgy." Vol. Volume 381. Edited by Chandan K. Sen and Gregg L. Semenza. San Diego: Elsevier Academic Press, April 2004.

 

Editorial Activities

1999 - present Antioxidants & Redox Signaling
1999 - present Antioxidants & Redox Signaling
2000 - present Nutrition Research
2000 - present Journal of Neuroscience
2000 - present Journal of Internal Medicine
2000 - present Experimental Neurology
2000 - present Experimental Brain Research
2000 - present Clinical Biochemistry
2000 - present Arteriosclerosis, Thrombosis, and Vascular Biology
2000 - present Oxidative Medicine and Cellular Longevity
2001 - present International Journal of Sports Medicine
2002 Methods in Enzymology
2002 Methods in Enzymology
2004 Methods in Enzymology
2005 - present Life Sciences
2006 - present Free Radical Biology and Medicine
2006 - present Journal of Agricultural and Food Chemistry
2006 - present European Journal of Physiology
2009 - present Journal of the American Collage of Nutrition
2010 - present Lipids
2010 - present Biochimica et Biophysica Acta
2012 - present American Journal of Physiology
 

Honors

2002 - present Junior Investigator Award. Wound Healing: Oxygen & Emerging Therapeutics, The Ohio State University.
2008 - present Poster winner, DHLRI Research Poster Competition. 3rd Annual Research Retreat, DHLRI, The Ohio State University.
2012 - present Assistant Professor Award, 5th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care Conference. The Ohio State University.
 

Journal Articles

Atalay, M., Khanna, S., Laaksonen, D. E., Hänninen, O., Seene, T., Vider, J Korho., and Sen, C. K.. "Glutathione dependent antioxidant protection in skeletal muscle: exercise and training." Acta Medica Baltica. Vol. 4, no. 1. (January 1997.): 10-14.

Sen, C. K., Khanna S., Reznick, A. Z., Roy, S., and Packer, L.. "Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells." Biochem Biophys Res Commun. Vol. 237, no. 3. (August 1997.): 645-649.

Khanna, S., Atalay, M., Lodge J. K., Laaksonen, D., Roy, S., Hänninen, O., Packer, L., and Sen, C. K.. "Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary - lipoic acid supplementation." Biochem Mol Biol Int. Vol. 46, no. 2. (October 1998.): 297-306.

Khanna, S., Sen, C. K., Roy, S.,Christen, M. O., and Packer, L.. "Protective effect of anethole dithiolethione against oxidative stress induced cytotoxicity in human Jurkat T cells." Biochem Pharmacol. Vol. 56, no. 1. (July 1998.): 61-69.

Sen, C.K., Roy, S., Khanna, S., and Packer, L.. "Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection." Methods Enzymol. Vol. 299, (January 1999.): 239-246.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid." Am. J. Physiol. Vol. 276, no. regulatory Integrative Comp. Physiol. 5 Pt 2. (May 1999.): R1327-R1333.

Khanna, S., Atalay, M., Laaksonen, D., Gul, M., Roy, S and Sen, C. K.. "-Lipoate supplementation: tissue glutathione homeostasis at rest and following exercise." J. Appl. Phyiol. Vol. 86, no. 4. (April 1999.): 1191-1196.

Atalay, M., Laaksonen, D. E., Khanna, S., Korhonen, E. K., Hänninen, O,. and Sen, C. K.. "Vitamin E regulates changes in tissue antioxidants induced by fish oil and accute exercise." Med Sci Sports Exerc. Vol. 32, no. 3. (March 2000.): 601-607.

Sen, C.K., Khanna, S., Roy, S., and Packer, L.. "Molecular basis of vitamin E action: Tocotrienol potently inhibits glutamate induced pp60c-Src kinase activation and death of HT4 neuronal cells." J Biol Chem. Vol. 275, no. 17. (April 2000.): 13049-13055.

Khanna, S., Roy, S., Bagchi, D., Bagchi, M., and Sen, C.K.. "Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract." Free Radic Biol Med. Vol. 31, no. 1. (July 2001.): 38-42.

Sen, C.K., Khanna, S., Venojarvi, M., Trikha, P., Ellison, E. C., Hunt, T.K and Roy, S. "Copper induced vascular endothelial growth factor expression and wound healing." Am J Physiol Heart Circ Physiol. Vol. 282, no. 5. (May 2002.): H1821-H1827.

Sen, C.K., Khanna, S., Babior, B. M., Hunt, T.K., Ellison, E. C., and Roy, S. "Oxidant-induced vascular endothelial growth factor expression and wound healing." J Biol Chem. Vol. 277, no. 36. (September 2002.): 33284-33290.

Roy, S., Khanna, S., Alessio, H.M., Vider, J., Bagchi, D., Bagchi, M., and Sen, C.K.. "Anti-angiogenic property of edible berries." Free Radic Res. Vol. 36, no. 9. (January 2002.): 1023-1031.

Sen, C.K., Khanna, S., Gordillo, G., Bagchi, D., Bagchi, M and Roy, S. "Oxygen, oxidants, and antioxidant in wound healing: an emerging paradigm- Review." Ann N Y Acad Sci. Vol. 957, (May 2002.): 239-249.

Khanna, S., Venojarvi, M., Roy, S., Sharma, S., Trikha, P., Bagchi, D., Bagchi, M and Sen, C. K.. "Dermal wound healing properties of redox-active grape seed proanthocyanidins." Free Radic Biol Med. Vol. 33, no. 8. (January 2002.): 1089-1096.

Roy, S., Lado B.H., Khanna, S and Sen, C.K.. "Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarry analysis." FEBS Lett. Vol. 530, no. 1-3. (October 2002.): 17-.

Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P.W., Ratan, R.R., and Sen, C.K.. "Molecular basis of vitamin E action. Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration." J Biol Chem. Vol. 278, no. 44. (October 2003.): 43508-43515.

Roy, S., Khanna, S., Bickerstaff, A.A., Subramanian, S.V., Atalay, M., Bierl, M., Pendyala, S., Levy, D., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C.G., and Sen C.K.. "Oxygen sensing by primary cardiac fibroblasts: akey role of p21waf1/Cip1/Sdi1 in signaling for perceived hyperoxia." Circ Res. Vol. 92, no. 3. (February 2003.): 264-271.

Roy, S., Khanna, S., Wallace, W.A., Lappalainen, J., Rink, C., Cardounel, A.J., Zweier, J.L., and Sen, C.K.. "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart." J Biol Chem. Vol. 278, no. 47. (November 2003.): 47129-47135.

McClelland, G.B., Khanna, S., Gonzalez, G.F., Butz, C.E., and Brooks, G.A.. "Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system?." Biochem Biophys Res Commun. Vol. 304, no. 1. (April 2003.): 130-135.

Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M, Sen CK. "Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement." Gene Expr. Vol. 11, no. 5-6. (January 2004.): 251-262.

Atalay, M., Oksala, N.K., Laaksonen, D.E., Khanna, S., Nakao, C., Lappalainen, J., Roy, S., Hanninen, O.O., and Sen C.K. "Exercise training modulates heat shock protein response in diabetic rats." J Appl Physiol. Vol. 97, no. 2. (August 2004.): 605-611.

Sen, C.K., Khanna S, Roy S. "Tocotrienol: The natural vitamin E to defend the nervous system?." Ann NY Acad Sci. Vol. 1031, (January 2004.): 127-142.

Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C, Notestine MA, DeVries AC, Parinandi NL, Sen CK. "Neuroprotective properties of the natural vitamin E alpha-tocotrienol." Stroke. Vol. 36, no. 10. (October 2005.): 2258-2264.

Roy S, Khanna S, Yeh PE, Rink C, Malarkey WB, Kiecolt-Glaser J, Laskowski B, Glaser R, Sen CK. "Wound site neutrophil transcriptome in response to psychological stress in young men." Gene Expr. Vol. 12, no. 4-6. (January 2005.): 273-287.

Patel V, Chivukula IV, Roy S, Khanna S, He G, Ojha N, Mehrotra A, Dias LM, Hunt TK, Sen CK. "Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress." Antioxid Redox Signal. Vol. 7, no. 9-10. (January 2005.): 1377-1387.

Khanna S, Patel V, Rink C, Roy S, Sen CK. "Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice." Free Radic Biol Med. Vol. 39, no. 10. (November 2005.): 1310-1319.

Roy S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen CK. "Human genome screen to identify the genetic basis of the anti-inflammatory effects of boswellia in microvascular endothelial cells." DNA Cell Biol. Vol. 24, no. 4. (April 2005.): 244-255.

Roy S, Khanna S, Nallu K, Hunt TK, Sen CK. "Dermal wound healing is subject to redox control." Mol Ther. Vol. 13, no. 1. (January 2006.): 211-220.

Patel V, Khanna S, Roy S, Ezziddin O, Sen CK. "Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal." Free Radic Res. Vol. 40, no. 7. (July 2006.): 763-771.

Oksala NK, Laaksonen DE, Lappalainen J, Khanna S, Nakao C, Hanninen O, Sen CK, Atalay M. "Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation." J Diabetes Complications. Vol. 20, no. 4. (July 2006.): 257-261.

Rink C, Roy S, Khanna S, Rink T, Bagchi D, Sen CK. "Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type II Leprdb obese diabetic mice with niacin-bound chromium." Physiol Genomics. Vol. 27, no. 3. (November 2006.): 370-379.

Sen CK, Khanna S, Roy S. "Perceived hyperoxia: Oxygen-induced remodeling of the reoxygenated heart- Review." Cardiovasc Res. Vol. 71, no. 2. (July 2006.): 280-288.

Bagchi D, Roy S, Patel V, He G, Khanna S, Ojha N, Phillips C, Ghosh S, Bagchi M, Sen CK. "Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries." Mol Cell Biochem. Vol. 281, no. 1-2. (January 2006.): 197-209.

Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. "Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia." Antioxid Redox Signal. Vol. 8, no. 3-4. (March 2006.): 653-660.

Sen CK, Khanna S, Roy S. "Tocotrienols: Vitamin E beyond tocopherols- Review." Life Sci. Vol. 78, no. 18. (March 2006.): 2088-2098.

Roy S, Khanna S, Kuhn DE, Rink C, Williams WT, Zweier JL, Sen CK. "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix." Physiol Genomics. Vol. 25, no. 3. (May 2006.): 364-374.

Khosla P, Patel V, Whinter JM, Khanna S, Rakhkovskaya M, Roy S, Sen CK. "Postprandial levels of the natural vitamin e tocotrienol in human circulation." Antioxid Redox Signal. Vol. 8, no. 5-6. (May 2006.): 1059-1068.

Khanna S, Roy S, Maurer M, Ratan RR, Sen CK. "Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point." Free Radic Biol Med. Vol. 40, no. 12. (June 2006.): 2147-2154.

Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK. "Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol." J Neurochem. Vol. 98, no. 5. (September 2006.): 1474-1486.

Roy S, Khanna S, Rink T, Radtke J, Williams WT, Biswas S, Schnitt R, Strauch AR, Sen CK. "p21waf1/cip1/sdi1 as a Central Regulator of Inducible Smooth Muscle Actin Expression and Differentiation of Cardiac Fibroblasts to Myofibroblasts." Mol Biol Cell. Vol. 18, no. 12. (December 2007.): 4837-4846.

Sen CK, Khanna S, Roy S. "Tocotrienols in health and disease: the other half of the natural vitamin E family- Review." Mol Aspects Med. Vol. 28, no. 5-6. (January 2007.): 692-728.

Roy S, Patel D, Khanna S, Gordillo G, Biswas S, Friedman A, Sen CK. "Genome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue." Proc Natl Acad Sci U S A. Vol. 104, no. 36. (September 2007.): 14472-14477.

Sen CK, Khanna S, Rink C, Roy S. "Tocotrienols: the emerging face of natural vitamin E- Review." Vitam Horm. Vol. 76, (January 2007.): 203-261.

Khanna S, Roy S, Park HA, Sen CK. "Regulation of c-SRC activity in glutamate-induced neurodegeneration." J Biol Chem. Vol. 282, no. 32. (August 2007.): 23482-23490.

Roy S, Shah H, Rink C, Khanna S, Bagchi D, Bagchi M, Sen CK. "Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement." DNA Cell Biol. Vol. 26, no. 9. (January 2007.): 627-639.

Shilo S, Roy S, Khanna S, Sen CK. "MicroRNA in cutaneous wound healing: a new paradigm- Review." DNA Cell Biol. Vol. 26, no. 4. (April 2007.): 227-237.

Oksala NK, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. "Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney." Antioxid Redox Signal. Vol. 9, no. 4. (April 2007.): 497-506.

Kuhn D, Roy S, Radtke J, Khanna S, Sen CK. "Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes." Am J Physiol Heart Circ Physiol. Vol. 292, no. 3. (March 2007.): H1245-H1253.

Roy S, Khanna S, Rink C, Biswas S, Sen CK. "Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome." Physiol Genomics. Vol. 34, no. 2. (July 2008.): 162-184.

Roy S, Khanna S, Sen CK. "Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing." Free Radic Biol Med. Vol. 44, no. 2. (January 2008.): 180-192.

Ojha N, Roy S, He G, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK. "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing." Free Radic Biol Med. Vol. 44, no. 4. (February 2008.): 682-691.

Gordillo GM, Roy S, Khanna S, Schlanger R, Khandelwal S, Phillips G, Sen CK. "Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds." Clin Exp Pharmacol Physiol. Vol. 35, no. 8. (August 2008.): 957-964.

Khanna S, Park HA, Sen CK, Golakoti T, Sengupta K, Venkateswarlu S, Roy S. "Neuroprotective and anti-inflammatory properties of a novel demethylated curcuminoid." Antioxid Redox Signal. Vol. 20(1), (August 2008.): 83-9.

Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S. "Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure." Circ Res. Vol. 103, no. 12. (December 2008.): 1466-1472.

Shilo S, Roy S, Khanna S, Sen CK. "Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells." Arterioscler Thromb Vasc Biol. Vol. 28, no. 3. (March 2008.): 471-477.

Rink C, Christoforidis G, Abduljalil A, Kontzialis M, Bergdall V, Roy S, Khanna S, Slivka A, Knopp M, Sen CK. "Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines." Proc Natl Acad Sci U S A. Vol. 105, no. 37. (September 2008.): 14100-14105.

Lappalainen Z, Lappalainen J, Oksala NK, Laaksonen DE, Khanna S, Sen CK, Atalay M. "Exercise training and experimental diabetes modulate heat shock protein response in brain." Scand J Med Sci Sports. Vol. 20(1), (November 2008.): 83-9.

Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK. "MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue." Cardiovasc Res. Vol. 82, no. 1. (April 2009.): 21-29.

Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK. "Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm." Antioxid Redox Signal. Vol. 11, no. 1. (January 2009.): 47-58.

Sen CK, Gordillo GM, Khanna S, Roy S. "Micromanaging Vascular Biology: Tiny MicroRNAs Play Big Band." J Vasc Res. Vol. 46, no. 6. (June 2009.): 527-540.

Lappalainen Z, Lappalainen J, Oksala NK, Laaksonen DE, Khanna S, Sen CK, Atalay M. "Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain." J Appl Physiol. Vol. 106, no. 2. (February 2009.): 461-467.

Roy S, Biswas S, Khanna S, Gordillo G, Bergdall V, Green J, Marsh CB, Gould LJ, Sen CK. "Characterization of a preclinical model of chronic ischemic wound." Physiol Genomics. Vol. 37, no. 3. (May 2009.): 211-224.

Park HA, Khanna S, Rink C, Gnyawali S, Roy S, Sen CK. "Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway." Cell Death Differ. Vol. 16, no. 8. (August 2009.): 1167-1179.

Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S.. "Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice." PLoS One. Vol. 5, no. 3. (March 2010.): e9539-.

Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen CK, Khanna S.. "Oxygen-sensitive outcomes and gene expression in acute ischemic stroke." Journal of Cerebral Blood Flow and Metabolism. Vol. 30(7), (February 2010.): 1275-87.

Khanna S, Parinandi NL, Kotha SR, Roy S, Rink C, Bibus D, Sen CK. "Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A and causes neuroprotection." J Neurochem. Vol. 112, no. 5. (March 2010.): 1249-1260.

Lappalainen Z, Lappalainen J, Laaksonen DE, Oksala KJ, Khanna S, Sen CK, Atalay M. "Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes." Int J Sport Nutr Exerc Metab. Vol. 20, no. 3. (June 2010.): 206-215.

Roy S, Khanna S, Azad A, Schnitt R, He G, Weigert C, Ichijo H, Sen CK. "Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts." Cardiovasc Res. Vol. 87(4), no. Cardiovasc. (April 2010.): 647-55.

Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK. "Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds." Proc Natl Acad Sci U S A. Vol. 107, no. 15. (April 2010.): 6976-6981.

Sen CK, Rink C, Khanna S.. "Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease." J Am Coll Nutr. Vol. 29, no. 3 Suppl. (June 2010.): 314S-323S.

Gnyawali SC, Roy S, Driggs J, Khanna S, Ryan T, Sen CK. "High-frequency high-resolution echocardiography: first evidence on non-invasive repeated measure of myocardial strain, contractility, and mitral regurgitation in the ischemia-reperfused murine heart." J Vis Exp. Vol. 41, (July 2010.): 1781-.

Lappalainen J, Lappalainen Z, Oksala NK, Laaksonen DE, Khanna S, Sen CK. "Atalay M. Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain." Cell Biochem Funct. Vol. 28, no. 8. (October 2010.): 644–650-.

Chan,Yuk,Cheung; Khanna,Savita; Roy,Sashwati; Sen,Chandan,K. "miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 3. (January 2011.): 2047-2056.

Roy,Sashwati; Dickerson,Ryan; Khanna,Savita; Collard,Eric; Gnyawali,Urmila; Gordillo,Gayle,M; Sen,Chandan,K. "Particulate beta-glucan induces TNF-alpha production in wound macrophages via a redox-sensitive NF-kappa beta-dependent pathway." WOUND REPAIR AND REGENERATION. Vol. 19, no. 3. (May 2011.): 411-419.

Rink,Cameron; Gnyawali,Surya; Peterson,Laura; Khanna,Savita. "Oxygen-Inducible Glutamate Oxaloacetate Transaminase as Protective Switch Transforming Neurotoxic Glutamate to Metabolic Fuel During Acute Ischemic Stroke." ANTIOXIDANTS & REDOX SIGNALING. Vol. 14, no. 10. (May 2011.): 1777-1785.

Park,Han-A; Kubicki,Natalia; Gnyawali,Surya; Chan,Yuk,Cheung; Roy,Sashwati; Khanna,Savita; Sen,Chandan,K. "Natural Vitamin E alpha-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1." STROKE. Vol. 42, no. 8. (August 2011.): 2308-U450.

Rink,Cameron; Christoforidis,Greg; Khanna,Savita; Peterson,Laura; Patel,Yojan; Khanna,Suchin; Abduljalil,Amir; Irfanoglu,Okan; Machiraju,Raghu; Bergdall,Valerie,K; Sen,Chandan,K. "Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis." JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Vol. 31, no. 11. (November 2011.): 2218-2230.

Patel,Viren; Rink,Cameron; Khanna,Savita; Sen,Chandan,K. "Tocotrienols: The lesser known form of natural vitamin E." INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY. Vol. 49, no. 10. (October 2011.): 732-738.

Roy,Sashwati; Driggs,Jason; Elgharably,Haytham; Biswas,Sabyasachi; Findley,Muna; Khanna,Savita; Gnyawali,Urmila; Bergdall,Valerie,K; Sen,Chandan,K. "Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation." WOUND REPAIR AND REGENERATION. Vol. 19, no. 6. (November 2011.): 753-766.

Rink C, Khanna S.. "MicroRNA in Ischemic Stroke Etiology and Pathology." Physiol Genomics. Vol. 43(10), (May 2011.): 521-8.

Rink C, Khanna S.. "Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke." Antioxid Redox Signal. Vol. 14(10), (May 2011.): 1889-903.

Christoforidis GA, Rink C, Kontzialis MS, Mohammad Y, Koch RM, Abduljalil AM, Bergdall VK, Roy S, Khanna S, Slivka AP, Knopp MV, Sen CK. "An Endovascular Canine Middle Cerebral Artery Occlusion Model for the Study of Leptomeningeal Collateral Recruitment." Invest Radiol.. Vol. 46(1), (January 2011.): 34-40.

Patel,Viten; Rink,Cameron; Gordillo,Gayle,M; Khanna,Savita; Gnyawali,Urmila; Roy,Sashwati; Shneker,Bassel; Ganesh,Kasturi; Phillips,Gary; More,J,Layne; Sarkar,Atom; Kirkpatrick,Robert; Elkhammas,Elmahdi,A; Klatte,Emily; Miller,Michael; Firstenberg,Michael,S; Chiocca,E,Antonio; Nesaretnam,Kalanithi; Sen,Chandan,K. "Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients." JOURNAL OF NUTRITION. Vol. 142, no. 3. (March 2012.): 513-519.

Chan,Yuk,Cheung; Roy,Sashwati; Khanna,Savita; Sen,Chandan,K. "Downregulation of Endothelial MicroRNA-200b Supports Cutaneous Wound Angiogenesis By Desilencing GATA Binding Protein 2 and Vascular Endothelial Growth Factor Receptor 2." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Vol. 32, no. 6. (June 2012.): 1372-1382.

Ganesh,Kasturi; Das,Amitava; Dickerson,Ryan; Khanna,Savita; Parinandi,Narasimham,L; Gordillo,Gayle,M; Sen,Chandan,K; Roy,Sashwati. "Prostaglandin E-2 Induces Oncostatin M Expression in Human Chronic Wound Macrophages through Axl Receptor Tyrosine Kinase Pathway." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 5. (September 2012.): 2563-2573.

Chan,Yuk,Cheung; Roy,Sashwati; Huang,Yue; Khanna,Savita; Sen,Chandan,K. "The MicroRNA miR-199a-5p Down-regulation Switches on Wound Angiogenesis by Derepressing the v-ets Erythroblastosis Virus E26 Oncogene Homolog 1-Matrix Metalloproteinase-1 Pathway." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 287, no. 49. (November 2012.): 41032-41043.

Elgharably,Haytham; Roy,Sashwati; Khanna,Savita; Abas,Motaz; Dasghatak,Piya; Das,Amitava; Mohammed,Kareem; Sen,Chandan,K. "A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds." WOUND REPAIR AND REGENERATION. Vol. 21, no. 3. (May 2013.): 473-481.

Roy,Sashwati; Banerjee,Jaideep; Gnyawali,Surya,C; Khanna,Savita; He,Guanglong; Pfeiffer,Douglas; Zweier,Jay,L; Sen,Chandan,K. "Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction." PLOS ONE. Vol. 8, no. 6. (June 2013.): e66789-.

Khanna,Savita; Rink,Cameron; Ghoorkhanian,Reza; Gnyawali,Surya; Heigel,Mallory; Wijesinghe,Dayanjan,S; Chalfant,Charles,E; Chan,Yuk,Cheung; Banerjee,Jaideep; Huang,Yue; Roy,Sashwati; Sen,Chandan,K. "Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size." JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Vol. 33, no. 8. (August 2013.): 1197-1206.

Gordillo,G,M; Biswas,A; Khanna,S; Pan,J; Sen,C,K. "MICRORNA IS REQUIRED FOR IN VIVO ANGIOGENESIS." WOUND REPAIR AND REGENERATION. Vol. 21, no. 2. (March 2013.): A24-A24.

Gordillo GM, Biswas A, Khanna S, Pan X, Sinha M, Roy S, Sen CK.. "Dicer Knockdown Inhibits Endothelial Cell Tumor Growth via MicroRNA 21a-3p Targeting of Nox-4.." J Biol Chem.. Vol. 289, no. 13. (March 2014.): 9027-38.

Das,Amitava; Ganesh,Kasturi; Khanna,Savita; Sen,Chandan,K; Roy,Sashwati. "Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation." JOURNAL OF IMMUNOLOGY. Vol. 192, no. 3. (February 2014.): 1120-1129.

Roy,Sashwati; Elgharably,Haytham; Sinha, Mithun; Ganesh,Kasturi; Chaney, Sommer; Mann, E; Miller, Cheryl; Khanna,Savita; Bergdall, Valerie K; Powell, Heather M; Cook, Charles H; Gordillo Gayle, Wozniak, Daniel; Sen, Chandan K.. "Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function." J Pathol.. Vol. 233, no. 4. (August 2014.): 331-343.

Banerjee,Jaideep; Das Ghatak,Piya; Roy,Sashwati; Khanna,Savita; Sequin,Emily,K; Bellman,Karen; Dickinson,Bryan,C; Suri,Prerna; Subramaniam,Vish,V; Chang,Christopher,J; Sen,Chandan,K. "Improvement of human keratinocyte migration by a redox active bioelectric dressing.." PloS one. Vol. 9, no. 3. (January 2014.): e89239-.

 

Inventions and Patents

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Topical Application of Humidified and Warmed Oxygen (TAHWO) for Dermal Wound Care." Filed January 2003.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Control of Stroke-Induced Brain Damage by Oxygen Theory." Filed January 2005.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Novel Tissue Oximetry Design for Research and Clinical Use." Filed January 2006.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Multidrug Resistance-associated Protein 1 (MRP1) as a therapuetic Agent." Filed January 2010.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "natural Vitamin E Tocotrienol for the Treatment of Burn and Scar." Filed January 2011.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Cold Water Face Treatment to Increase Cerebral Bool Flow in Trauma and Disease." Filed January 2011.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Antiplatelet Effects of Natural Viatmin E Alpha-Tocotrienol." Malaysian Palm Oil Board (MPOB).. Filed July 2012.

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Tocovid SupraBioo to treat Hot Flashes in Humans." Filed January 2013.

Chadan Sen; Sashwati Roy; Savita Khanna. "Protective and therapeutic uses for tocotrienols." Filed August 2006.

Sen, Chandan; Roy, Sashwati; Khanna, Savita. "Methods and compositions for the topical oxygenation of hypoxic tissue." Filed January 2007.

Chandan K Sen; Savita Khanna; Sashwati Roy; Sangly P Srinivas. "Apparatus, System and Method for Tissue Oximetry." Filed December 2006.

Sen, Chandan; Roy, Sashwati; Rink, Cameron; Khanna, Savita. "Methods for Treating Burn and Scar Injury Using Tocotrienol Compostitions." Hovid LLC.. Filed June 2012.

Sen, Chandan; Roy, Sashwati; Khanna, Savita; Rink, Cameron. "Methods for Reducing the Occurance of Hot Flashes." Hovid LLC.. Filed July 2013.

Sen, Chandan; Roy, Sashwati; Rink, Cameron; Khanna, Savita. "Methods for Improving Liver Function." Filed May 2012.

Sen, Chandan; Roy, Sashwati; Khanna, Savita; Rink, Cameron. "Method of Ameliorating Clotting Pathologies and Related Materials and Methods." Filed April 2013.

 

Presentations

"[unspecified]." Presented at 1st Mtg of the Japanese Society for Tocotrienol Research, Hyogo, JP|JPN. (December 2004)

"Oxygen-Sensitive Reset of Inducible Hif Transactivation Response." Presented at Society for Neuroscience 35th Annual Meeting, Washington, DC. (November 2005)

"-Tocotrienol: A Potent form of Natural Vitamin E Against Stroke-Related Neurodegeneration." Presented at XIII International Congress of the Free Radical Society International, Davos, CH|CHE. (May 2006)

"Potent Neuroprotection by the Natural Vitamin E α-Tocotrienol: Beyond Antioxidant Mechanisms." Presented at Society for Neuroscience 36th Annual Meeting, Atlanta, Georgia. (October 2006)

"Regulation of c-Src Activity in Glutamate-Induced Neurodegeneration." Presented at Society for Neuroscience 37th Annual Meeting, San Diego, California. (November 2007)

"Regulation of c-Src Activity in Glutamate-Induced Neurodegeneration." Presented at International Conference on Free Radicals & Natural Products in Health and Seventh Annual Meeting of the Society of Free Radical Research India, Jaipur, IN|IND. (February 2008)

"Tocotrienol Protects Mature Cortical Neurons Against Arachidonic Acid-Induced Cell Death Through Modulation of Lipoxygenase." Presented at Society for Neuroscience 38th Annual Meeting, Washington, DC. (November 2008)

"Arachidonic Acid Pathway as a key Target for Neuroprotection by Nanomolar α-Tocotrienol." Presented at Society for Neuroscience 39th Annual Meeting, Chicago, Illinois. (October 2009)

"Characterization of the Therapeutic Potential for Supplemental Oxygen Therapy in Acute Ischemic Stroke." Presented at International Conference on Advances in Free Radicals & Natural Products, Antioxidants and Radioprotectors in Health and 9th Annual Meeting of the Society of Free Radical Research India, Hyderabad, IN|IND. (January 2010)

"Arachidonic Acid Pathway as a Key Target for Neuroprotection by Nanomolar α-Tocotrienol." Presented at Annual meeting of the Oxygen Club of California, Santa Barbara, California. (February 2010)

"Bioavailability of Orally Supplemented Tocotrienol in Human Tissues & Organs." Presented at 1st International Conference on Tocotrienols and Chronic Diseases, Las Vegas. (July 2010)

"Natural Vitamin E Tocotrienol Against Stroke." Presented at OSUN spring seminar series, . (May 2010)

"Natural Vitamin E Tocotrienol Against Stroke." Presented at International Conference on Recent Trends in Therapeutic Advancement of Free Radical Science and 10th Annual Meeting of the Society of Free Radical Research India, chennai, IN|IND. (January 2011)

"MRP1: A Novel Tocotrienol Target against Stroke." Presented at 2nd International Conference on Tocotrienols and Chronic Diseases., Las Vegas, US|USA. (July 2011)

"Oxygen-Inducible Glutamate Oxaloacetate Transaminase as Protective Switch Transforming Neurotoxic Glutamate to Metabolic Fuel during Acute Ischemic Stroke." Presented at Society for Neuroscience 41st Annual Meeting, Washington, DC. (November 2011)

"Vitamin E alpha-Tocotrienol Protects Against Acute Ischemic Stroke by Preventing Loss of miR-29b." Presented at 5th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care Conference, Columbus, Ohio. (March 2012)

"Palm Vitamin E alpha-Tocotrienol Protects Against Acute Ischemic Stroke by Preventing Loss of miR-29b." Presented at FAV Health 2012, The Fifth International Symposium on Human Health Effects of Fruits and Vegetables, Dharwad & Goa, IN|IND. (January 2013)

"The microRNA Basis of Palm Tocotrienol Neuroprotection." Presented at PALM oil nutrition week, Pataling Jaya, MY|MYS. (May 2013)

"Loss of miR-29b Following Acute Ischemic Stroke Contributes to Neurodegeneration and Infarct Size." Presented at 6th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care, Columbus, Ohio. (March 2013)

"Inducible Glutamate Oxaloacetate Tranaminase: A New Target for Stroke Therapy." Presented at 7th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care, Columbus, Ohio. (March 2014)

"Inducible Glutamate Oxaloacetate Transaminase a New Target for Stroke Therapy." Presented at International Stroke Conference 2014, San Diego,, California. (February 2014)

 

Professional Activities

present Lipoprotein Metabolism, Kuopio, Finland, August 14-16, 1995.
present Emerging Potential of Antioxidant Therapy, Goa, India, January 9-11, 1999.
present TULES-GS Course “Muscle cellular respiration, oxidative stress and damage in exercise” Kuopio, Finland, December 18-20, 1995.
present International symposium and practical course on Skeletal Muscle Research. Part II, Jyväskylä, Finland, November 6-11, 1995.
present Experimental Biology, New Orleans, Louisiana, April 20-24, 2000.
present Annual meeting of the Oxygen Club of California, Santa Barbara, California, March 03-06, 1999.
present Gene Transfer “Strategies for in vivo gene transfer and techniques to monitor therapeutic effects” A.I.V Institute, Kuopio, Finland, September 2-7, 1996.
present 45th Annual meeting of the American college of sports medicine, Orlando, Florida, June 03-06, 1998.
present 46th Annual meeting of the American College of Sports Medicine, Seattle, Washington, June 01-05, 1999.
present Wound Healing: Oxygen & Emerging Therapeutics, Columbus, Ohio, September 12-15, 2002.
present Annual meeting of the Oxygen Club of California, Santa Barbara, California, Feb 27- March 1, 1997.
present American Society of Biochemistry and Molecular and Cellular Biology, San Francisco, California, May 16-20, 1999.
present Experimental Biology 2000, San Diego,California, April 15-18, 2000.
present 8th Annual Meeting of the Oxygen Society, Research Triangle Park, North Carolina, November 15-19, 2001.
present Society for Neuroscience 34th Annual Meeting, San Diego, California, October 23-27, 2004.
present III International Congress of Pathophysiology, Lahti, Finland, June 28-July 03, 1998.
present Experimental Biology 1998, San Francisco, California, April 18-22, 1998.
present Annual meeting of the Oxygen Club of California, Santa Barbara, California, February 03-05, 1998.