Savita Khanna, Ph.D.

Current OSU Appointment

Assistant Professor, Surgery

Chapters in Books

Atalay, M., Larson, D. E., Khanna, S., Hänninen, O., and Sen, C.K.. "Oxidative stress induced by physical exercise." In Natural Antioxidants and Food Qualityin Atherosclerosis and cancer Prevention. Edited by J. T. Kumpulainen and J. T. Salonen. 36-40. [unspecified]: The Royal Society of Chemistry, January 2010.

Larson, D. E., Atalay, M., Khanna, S., and Sen, C. K.. "Exercise and oxidative stress in diabetes mellitus." In Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention. Edited by J. T. Kumpulainen and J. T. Salonen. 22-26. [unspecified]: The Royal Society of Chemistry, January 2010.

Conferences

Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., Packer, L., Hänninen, O., and Sen, C.K.. "Tissue glutathione homeostasis in response to lipoate supplementation and exercise." Oxygen Club of California, World Congress. (February 1997). Abstract # 132-.

Roy, S., Kobuchi, H., Sen, C.K., Gohil, K., Khanna, S., and Packer, L.. "Antioxidant properties and cell regulation." Oxygen Club of California, World Congress. (February 1998). Abstract # 52-.

Khanna, S., Sen, C.K., Roy, S., Christen, M. O., and Packer, L.. "Anethole dithiolethione (Sulfarlem) protects against oxidative stress induced cytotoxicity in human Jurkat T cells." Oxygen Club of California, World Congress. (February 1998). Abstract # 123-.

Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., Packer, L., Hänninen, O., and Sen, C.K.. "lipoate supplementation in exercise induced oxidative stress." Experimental Biology. (April 1998). Abstract # 6024-.

Gohil, K., Sen, C.K., Roy, S., Khanna, S., and Packer, L.. "Differential regulation of tumor necrosis factor –alpha induced expression by alpha-lipoate." Experimental Biology. (April 1998). Abstract # 1866-.

Vider, L., Atalay, M., Gul, M., Laaksonen, D. E., Khanna, S., Roy, S., Hänninen, O., and Sen, C.K.. "Effects of endurance training on tissue vitamin E and Ubiquinone levels." III International Congress of Pathophysiology. (June 1998). Abstract #118-.

Khanna, S., Roy, S., Reznick, A. Z., Packer, L., and Sen, C.K.. "TNF� induced NF-�B activation in skeletal muscle L6 cells is regulated by cell glutathione status." III International Congress of Pathophysiology. (June 1998). Abstract #116-.

Gul, M., Laaksonen, D. E., Atalay, M., Khanna, S., Vider, L., Roy, S., Hänninen, O., and Sen, C.K.. "Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rats." III International Congress of Pathophysiology. (June 1998). Abstract #115-.

Gohil, K., Roy, S., Khanna, S., Packer, L., and Sen, C.K.. "�-lipoic acid alters gene expression in human Jurkat T lymphocytes." III International Congress of Pathophysiology. (June 1998). Abstract #77-.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in L6 skeletal myotubes and the role of R-lipoic acid." Oxygen Club of California, World Congress. (March 1999). Abstract # 155-.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in L6 skeletal myotubes and the role of R-lipoic acid." American Society of Biochemistry and Molecular and Cellular Biology. (May 1999). Abstract # 1002-.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in skeletal muscle." 46th Annual Meeting of the American College of Sports Medicine. (June 1999). Abstract #1523-.

Atalay, M., Khanna, S., Laaksonen, D. E., Gul, M., Vider, L., Roy, S., Hänninen, O., and Sen, C.K.. "�-Lipoic acid supplementation in exercise." 46th Annual Meeting of the American College of Sports Medicine. (June 1999). Abstract #394-.

Sen, C.K., Khanna, S., Roy, S., and Packer, L.. "Vitamin E Alpha tocotrienol potently inhibits glutamate induced pp60-Src kinase activation and death of HT4 neuronal cells." Experimental Biology. (April 2000). Abstract # 398.9-.

Sen, C.K., Khanna, S., Ryu. H., and Roy, S.. "Molecular basis of vitamin E neuroprotection." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #178-.

Roy, S., Khanna, S., Vider. J., and Sen, C.K.. "Redox control of wound angiogenesis." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #176-.

Khanna, S., Roy, S., Alessio, H., Bagchi, D., Bagchi, M., and Sen, C.K.. "Anti-angiogenic property of berry extracts." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #75-.

Khanna, S., Roy, S., Ryu, H., and Sen, C.K.. "Revisting the neuroprotective properties of vitamin E." Oxygen Club of California, World Congress. (March 2002). Abstract # 68-.

Sen, C.K., Khanna, S., Babior, B. M., Hunt, T.K., Ellison, E. C., and Roy, S.. "Redox control of wound repair." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 15-.

Roy, S., Khanna, S., Bickerstaff, A.A., Atalay, M., Bierl, M., Levy, D., Subramanian, S.V., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C.G., and Sen C.K.. "Oxygen sensitive signaling in the heart." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 20-.

Lappalainen, J., Atalay, M., Khanna, S., Roy, S., Nakao C., Oksala, N., Hanninen, O., and Sen C.K.. "Oxidative stress and heat shock proteins: protective role of physical exercise." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 50-.

Khanna, S., Roy, S., Ryu, H., Ratan R.R., and Sen, C.K.. "Molecular basis of vitamin E neuroprotection." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 49-.

Khanna, S., Roy, S., Chaki, S., and Sen, C.K.. "Tocotrienol: Nature’s Vitamin E for Neuroprotection?." Society for Neuroscience 34th Annual Meeting. (October 2004). .

Khanna, S. Slivka, A., Roy, S., Rink, C., Notestine, M. and Sen, C.K.. "Protective effects of oral �-tocotrienol in experimental stroke." 1st Mtg of the Japanese Society for Tocotrienol Research. (December 2004). .

Khanna, S., Roy, S., Maurer, M.R., Ratan.R.R., and Sen, C.K.. "Oxygen-sensitive reset of inducible hif transactivation response." Society for Neuroscience 35th Annual Meeting. (November 2005). .

Rink, C.L., Khanna, S.,Roy, S., Slivka, A., Craft, T.K.S.; Notestine, M., DeVries, C., and Sen, C.K.. "Natural vitamin E -tocotrienol protects against glutamate-induced neurodegeneration and stroke." Society for Neuroscience 35th Annual Meeting. (November 2005). .

Khanna, S., Ojha, N., Rink, C.L.S., Roy. S., and Sen, C. K.. "�-Tocotrienol: a potent form of natural vitamin E against stroke-related neurodegeneration." Society for Free Radical International XIII Congress. (August 2006). .

Khanna, S., Park, H., Rink, C.L.S., Roy, S. and Sen, C.K.. "Potent neuroprotection by the natural vitamin e α-tocotrienol: beyond antioxidant mechanisms." Society for Neuroscience 36th Annual Meeting. (October 2006). .

Rink, C.L.S., Khanna, S., Roy, S.; Park, H., Ghafourifar, P., and C.K.Sen. "The 12-lipoxygenase path of neurodegeneration: mitochondrial involvement and protection by the natural vitamin e α-tocotrienol." Society for Neuroscience 36th Annual Meeting. (October 2006). .

Roy, S., Khanna, S., and Sen, C.K.. "Fra2 mediates oxygen-induced tgfbeta-1 mrna expression in adult cardiac fibroblasts: significance in myocardial fibrosis following ischemia-reperfusion injury." American Heart Association. (November 2007). .

Rink, C.L.S., Khanna, S., Ojha, N., Roy, S., Radtke, J., and Sen, C.K.. "The oxygen-sensitive transcriptome in stroke-related injury of the brain: a therapeutic window of opportunity." Society for Neuroscience 37th Annual Meeting. (November 2007). .

Khanna, S., Roy, S., Park, H., and Sen, C.K.. "Regulation of c-src activity in glutamate-induced neurodegeneration." Society for Neuroscience 37th Annual Meeting. (November 2007). .

Rink, C. L., Christoforidis G. A., Kontzialis M., Bergdall V. K., Abduljalil, A., Roy, S., Khanna S., Knopp, M. V., and Sen, C. K.. "Novel pre-clinical model of acute ischemic stroke in canines: a minimally invasive neuroradiological approach of middle cerebral artery occlusion." Society for Neuroscience 38th Annual Meeting. (November 2008). .

Khanna, S., N. Parinandi., Roy, S., Rink., Park, H., and Sen, C.K.. "Tocotrienol protects mature cortical neurons against arachidonic acid-induced cell death through modulation of lipoxygenase." Society for Neuroscience 38th Annual Meeting. (November 2008). .

Khanna, S., Rink, C.L.S., Park, H., Roy, S., and Sen, C.K.. "Potent neuroprotection by the natural vitamin e α-tocotrienol: Beyond antioxidant mechanisms." International Conference on Free Radicals & Natural Products in Health and Seventh Annual Meeting of the Society of Free Radical Research India. (February 2008). .

Khanna, S., N. Parinandi, Kotha, S.R., Roy, S., C. Rink., Bibus, D., and Sen, C.K. "Arachidonic acid pathway as a key target for neuroprotection by nanomolar �-tocotrienol." Society for Neuroscience 39th Annual Meeting. (October 2009). .

Rink, C. L.,Roy, S., Khan, M., Ananth, P., Kuppusamy, P., Sen, C.K and Khanna, S.. "Characterization of the therapeutic potential for supplemental oxygen therapy in acute ischemic stroke." International Conference on Advances in Free Radicals & Natural Products, Antioxidants and Radioprotectors in Health and 9th Annual Meeting of the Society of Free Radical Research India. (January 2010). .

Khanna, S., N. Parinandi, Kotha, S.R., Roy, S., C. Rink., Bibus, D., and Sen, C.K. "Arachidonic acid pathway as a key target for neuroprotection by nanomolar �-tocotrienol." Annual meeting of the Oxygen Club of California. (February 2010). .

Edited Books

"Handbook of Oxidants and Antioxidants in Exercise." Edited by Sen, Packer & Hanninen. Amsterdam: Elsevier Science Publishers, January 2000.

Editorial Activities

present	Journal of Agricultural and Food Chemistry
present	International Journal of Sports Medicine
present	Biochimica et Biophysica Acta
present	Free Radical Biology and Medicine
present	European Journal of Physiology
present	Antioxidants & Redox Signaling
present	American Journal of Physiology
present	Lipids
present	Life Sciences
present	Journal of the American Collage of Nutrition
1999 - present	Antioxidants & Redox Signaling
2002	Methods in Enzymology
2002	Methods in Enzymology
2004	Methods in Enzymology

Honors

1995 - 2000	Finnish Graduate School Award in Musculo-Skeletal Problems (TULES). Academy of Finland.
1998	Young Investigator Award. OCC (Oxygen Club of California) World Congress.
2000	Order of the Horse Collar Knight.
2002	Junior Investigator Award. Wound Healing: Oxygen & Emerging Therapeutics.
2008	Poster winner. DHLRI Research Poster competition, 3rd Annual Research Retreat.

Journal Articles

Atalay, M., Khanna, S., Laaksonen, D. E., Hänninen, O., Seene, T., Vider, J Korho., and Sen, C. K.. "Glutathione dependent antioxidant protection in skeletal muscle: exercise and training." Acta Medica Baltica. Vol. 4, no. 1. (January 1997.): 10-14.

Sen, C. K., Khanna S., Reznick, A. Z., Roy, S., and Packer, L.. "Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells." Biochem Biophys Res Commun. Vol. 237, no. 3. (August 1997.): 645-649.

Khanna, S., Atalay, M., Lodge J. K., Laaksonen, D., Roy, S., Hänninen, O., Packer, L., and Sen, C. K.. "Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary �- lipoic acid supplementation." Biochem Mol Biol Int. Vol. 46, no. 2. (October 1998.): 297-306.

Khanna, S., Sen, C. K., Roy, S.,Christen, M. O., and Packer, L.. "Protective effect of anethole dithiolethione against oxidative stress induced cytotoxicity in human Jurkat T cells." Biochem Pharmacol. Vol. 56, no. 1. (July 1998.): 61-69.

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid." Am. J. Physiol. Vol. 276, no. regulatory Integrative Comp. Physiol. 5 Pt 2. (May 1999.): R1327-R1333.

Khanna, S., Atalay, M., Laaksonen, D., Gul, M., Roy, S and Sen, C. K.. "�-Lipoate supplementation: tissue glutathione homeostasis at rest and following exercise." J. Appl. Phyiol. Vol. 86, no. 4. (April 1999.): 1191-1196.

Sen, C.K., Roy, S., Khanna, S., and Packer, L.. "Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection." Methods Enzymol. Vol. 299, (January 1999.): 239-246.

Atalay, M., Laaksonen, D. E., Khanna, S., Korhonen, E. K., Hänninen, O,. and Sen, C. K.. "Vitamin E regulates changes in tissue antioxidants induced by fish oil and accute exercise." Med Sci Sports Exerc. Vol. 32, no. 3. (March 2000.): 601-607.

Sen, C.K., Khanna, S., Roy, S., and Packer, L.. "Molecular basis of vitamin E action: Tocotrienol potently inhibits glutamate induced pp60c-Src kinase activation and death of HT4 neuronal cells." J Biol Chem. Vol. 275, no. 17. (April 2000.): 13049-13055.

Khanna, S., Roy, S., Bagchi, D., Bagchi, M., and Sen, C.K.. "Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract." Free Radic Biol Med. Vol. 31, no. 1. (July 2001.): 38-42.

Roy, S., Venojarvi, M., Khanna, S., and Sen, C.K.. "Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC coulometric electrode array." Methods Enzymol. Vol. 352, (January 2002.): 326-332.

Roy, S., Khanna, S., Bentley, K., Beffrey, P., and Sen CK. "Functional genomics: high-density oligonucleotide arrays." Methods Enzymol. Vol. 353, (January 2002.): 487-497.

Roy, S., Khanna, S., Alessio, H.M., Vider, J., Bagchi, D., Bagchi, M., and Sen, C.K.. "Anti-angiogenic property of edible berries." Free Radic Res. Vol. 36, no. 9. (January 2002.): 1023-1031.

Sen, C.K., Khanna, S., Venojarvi, M., Trikha, P., Ellison, E. C., Hunt, T.K and Roy, S. "Copper induced vascular endothelial growth factor expression and wound healing." Am J Physiol Heart Circ Physiol. Vol. 282, no. 5. (May 2002.): H1821-H1827.

Sen, C.K., Khanna, S., Gordillo, G., Bagchi, D., Bagchi, M and Roy, S. "Oxygen, oxidants, and antioxidant in wound healing: an emerging paradigm- Review." Ann N Y Acad Sci. Vol. 957, (May 2002.): 239-249.

Sen, C.K., Khanna, S., Babior, B. M., Hunt, T.K., Ellison, E. C., and Roy, S. "Oxidant-induced vascular endothelial growth factor expression and wound healing." J Biol Chem. Vol. 277, no. 36. (September 2002.): 33284-33290.

Khanna, S., Venojarvi, M., Roy, S., Sharma, S., Trikha, P., Bagchi, D., Bagchi, M and Sen, C. K.. "Dermal wound healing properties of redox-active grape seed proanthocyanidins." Free Radic Biol Med. Vol. 33, no. 8. (January 2002.): 1089-1096.

Khanna, S., Venojarvi, M., Roy, S., and Sen, C.K.. "Glutamate-induced c-Src activation in neuronal cells." Methods Enzymol. Vol. 352, (January 2002.): 191-198.

Roy, S., Lado B.H., Khanna, S and Sen, C.K.. "Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarry analysis." FEBS Lett. Vol. 530, no. 1-3. (October 2002.): 17-.

Roy, S., Khanna, S., Bickerstaff, A.A., Subramanian, S.V., Atalay, M., Bierl, M., Pendyala, S., Levy, D., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C.G., and Sen C.K.. "Oxygen sensing by primary cardiac fibroblasts: akey role of p21waf1/Cip1/Sdi1 in signaling for perceived hyperoxia." Circ Res. Vol. 92, no. 3. (February 2003.): 264-271.

Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P.W., Ratan, R.R., and Sen, C.K.. "Molecular basis of vitamin E action. Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration." J Biol Chem. Vol. 278, no. 44. (October 2003.): 43508-43515.

Roy, S., Khanna, S., Wallace, W.A., Lappalainen, J., Rink, C., Cardounel, A.J., Zweier, J.L., and Sen, C.K.. "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart." J Biol Chem. Vol. 278, no. 47. (November 2003.): 47129-47135.

McClelland, G.B., Khanna, S., Gonzalez, G.F., Butz, C.E., and Brooks, G.A.. "Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system?." Biochem Biophys Res Commun. Vol. 304, no. 1. (April 2003.): 130-135.

Wallace, W. A., Cardounel, A. J., Khanna, S., and Sen, C.K.. "Survival surgery for coronary occlusion and reoxygenation in a rodent model." Methods Enzymol. Vol. 381, (January 2004.): 175-184.

Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M, Sen CK. "Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement." Gene Expr. Vol. 11, no. 5-6. (January 2004.): 251-262.

Atalay, M., Oksala, N.K., Laaksonen, D.E., Khanna, S., Nakao, C., Lappalainen, J., Roy, S., Hanninen, O.O., and Sen C.K.. "Exercise training modulates heat shock protein response in diabetic rats." J Appl Physiol. Vol. 97, no. 2. (August 2004.): 605-611.

Atalay, M., Oksala, N.K., Laaksonen, D.E., Khanna, S., Nakao, C., Lappalainen, J., Roy, S., Hanninen, O.O., and Sen C.K. "Exercise training modulates heat shock protein response in diabetic rats." J Appl Physiol. Vol. 97, no. 2. (August 2004.): 605-611.

Roy, S., Khanna, S and Sen, C.K.. "Perceived hyperoxia: oxygen-regulated signal transduction pathways in the heart." Methods Enzymol. Vol. 381, (January 2004.): 133-139.

Tewari, A.K., Roy, S, Khanna, S., and Sen C.K.. "Proteomic analysis of the mammalian cell nucleus." Methods Enzymol. Vol. 381, (January 2004.): 192-201.

Sen, C.K., Khanna S, Roy S. "Tocotrienol: The natural vitamin E to defend the nervous system?." Ann NY Acad Sci. Vol. 1031, (January 2004.): 127-142.

Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C, Notestine MA, DeVries AC, Parinandi NL, Sen CK. "Neuroprotective properties of the natural vitamin E alpha-tocotrienol." Stroke. Vol. 36, no. 10. (October 2005.): 2258-2264.

Roy S, Khanna S, Yeh PE, Rink C, Malarkey WB, Kiecolt-Glaser J, Laskowski B, Glaser R, Sen CK. "Wound site neutrophil transcriptome in response to psychological stress in young men." Gene Expr. Vol. 12, no. 4-6. (January 2005.): 273-287.

Patel V, Chivukula IV, Roy S, Khanna S, He G, Ojha N, Mehrotra A, Dias LM, Hunt TK, Sen CK. "Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress." Antioxid Redox Signal. Vol. 7, no. 9-10. (January 2005.): 1377-1387.

Khanna S, Patel V, Rink C, Roy S, Sen CK. "Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice." Free Radic Biol Med. Vol. 39, no. 10. (November 2005.): 1310-1319.

Roy S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen CK. "Human genome screen to identify the genetic basis of the anti-inflammatory effects of boswellia in microvascular endothelial cells." DNA Cell Biol. Vol. 24, no. 4. (April 2005.): 244-255.

Sen CK, Khanna S, Roy S. "Perceived hyperoxia: Oxygen-induced remodeling of the reoxygenated heart- Review." Cardiovasc Res. Vol. 71, no. 2. (July 2006.): 280-288.

Patel V, Khanna S, Roy S, Ezziddin O, Sen CK. "Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal." Free Radic Res. Vol. 40, no. 7. (July 2006.): 763-771.

Oksala NK, Laaksonen DE, Lappalainen J, Khanna S, Nakao C, Hanninen O, Sen CK, Atalay M. "Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation." J Diabetes Complications. Vol. 20, no. 4. (July 2006.): 257-261.

Rink C, Roy S, Khanna S, Rink T, Bagchi D, Sen CK. "Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type II Leprdb obese diabetic mice with niacin-bound chromium." Physiol Genomics. Vol. 27, no. 3. (November 2006.): 370-379.

Roy S, Khanna S, Nallu K, Hunt TK, Sen CK. "Dermal wound healing is subject to redox control." Mol Ther. Vol. 13, no. 1. (January 2006.): 211-220.

Sen CK, Khanna S, Roy S. "Tocotrienols: Vitamin E beyond tocopherols- Review." Life Sci. Vol. 78, no. 18. (March 2006.): 2088-2098.

Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. "Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia." Antioxid Redox Signal. Vol. 8, no. 3-4. (March 2006.): 653-660.

Bagchi D, Roy S, Patel V, He G, Khanna S, Ojha N, Phillips C, Ghosh S, Bagchi M, Sen CK. "Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries." Mol Cell Biochem. Vol. 281, no. 1-2. (January 2006.): 197-209.

Roy S, Khanna S, Kuhn DE, Rink C, Williams WT, Zweier JL, Sen CK. "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix." Physiol Genomics. Vol. 25, no. 3. (May 2006.): 364-374.

Khosla P, Patel V, Whinter JM, Khanna S, Rakhkovskaya M, Roy S, Sen CK. "Postprandial levels of the natural vitamin e tocotrienol in human circulation." Antioxid Redox Signal. Vol. 8, no. 5-6. (May 2006.): 1059-1068.

Khanna S, Roy S, Maurer M, Ratan RR, Sen CK. "Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point." Free Radic Biol Med. Vol. 40, no. 12. (June 2006.): 2147-2154.

Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK. "Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol." J Neurochem. Vol. 98, no. 5. (September 2006.): 1474-1486.

Sen CK, Khanna S, Roy S. "Tocotrienols in health and disease: the other half of the natural vitamin E family- Review." Mol Aspects Med. Vol. 28, no. 5-6. (January 2007.): 692-728.

Sen CK, Khanna S, Rink C, Roy S. "Tocotrienols: the emerging face of natural vitamin E- Review." Vitam Horm. Vol. 76, (January 2007.): 203-261.

Roy S, Patel D, Khanna S, Gordillo G, Biswas S, Friedman A, Sen CK. "Genome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue." Proc Natl Acad Sci U S A. Vol. 104, no. 36. (September 2007.): 14472-14477.

Roy S, Khanna S, Rink T, Radtke J, Williams WT, Biswas S, Schnitt R, Strauch AR, Sen CK. "p21waf1/cip1/sdi1 as a Central Regulator of Inducible Smooth Muscle Actin Expression and Differentiation of Cardiac Fibroblasts to Myofibroblasts." Mol Biol Cell. Vol. 18, no. 12. (December 2007.): 4837-4846.

Khanna S, Roy S, Park HA, Sen CK. "Regulation of c-SRC activity in glutamate-induced neurodegeneration." J Biol Chem. Vol. 282, no. 32. (August 2007.): 23482-23490.

Roy S, Shah H, Rink C, Khanna S, Bagchi D, Bagchi M, Sen CK. "Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement." DNA Cell Biol. Vol. 26, no. 9. (January 2007.): 627-639.

Shilo S, Roy S, Khanna S, Sen CK. "MicroRNA in cutaneous wound healing: a new paradigm- Review." DNA Cell Biol. Vol. 26, no. 4. (April 2007.): 227-237.

Oksala NK, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. "Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney." Antioxid Redox Signal. Vol. 9, no. 4. (April 2007.): 497-506.

Kuhn D, Roy S, Radtke J, Khanna S, Sen CK. "Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes." Am J Physiol Heart Circ Physiol. Vol. 292, no. 3. (March 2007.): H1245-H1253.

Shilo S, Roy S, Khanna S, Sen CK. "Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells." Arterioscler Thromb Vasc Biol. Vol. 28, no. 3. (March 2008.): 471-477.

Khanna S, Park HA, Sen CK, Golakoti T, Sengupta K, Venkateswarlu S, Roy S. "Neuroprotective and anti-inflammatory properties of a novel demethylated curcuminoid." Antioxid Redox Signal. (August 2008.): -.

Roy S, Khanna S, Sen CK. "Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing." Free Radic Biol Med. Vol. 44, no. 2. (January 2008.): 180-192.

Rink C, Christoforidis G, Abduljalil A, Kontzialis M, Bergdall V, Roy S, Khanna S, Slivka A, Knopp M, Sen CK. "Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines." Proc Natl Acad Sci U S A. Vol. 105, no. 37. (September 2008.): 14100-14105.

Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S. "Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure." Circ Res. Vol. 103, no. 12. (December 2008.): 1466-1472.

Lappalainen Z, Lappalainen J, Oksala NK, Laaksonen DE, Khanna S, Sen CK, Atalay M. "Exercise training and experimental diabetes modulate heat shock protein response in brain." Scand J Med Sci Sports. (November 2008.): -.

Ojha N, Roy S, He G, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK. "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing." Free Radic Biol Med. Vol. 44, no. 4. (February 2008.): 682-691.

Roy S, Khanna S, Rink C, Biswas S, Sen CK. "Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome." Physiol Genomics. Vol. 34, no. 2. (July 2008.): 162-184.

Gordillo GM, Roy S, Khanna S, Schlanger R, Khandelwal S, Phillips G, Sen CK. "Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds." Clin Exp Pharmacol Physiol. Vol. 35, no. 8. (August 2008.): 957-964.

Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK. "Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm." Antioxid Redox Signal. Vol. 11, no. 1. (January 2009.): 47-58.

Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK. "MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue." Cardiovasc Res. Vol. 82, no. 1. (April 2009.): 21-29.

Sen CK, Gordillo GM, Khanna S, Roy S. "Micromanaging Vascular Biology: Tiny MicroRNAs Play Big Band." J Vasc Res. Vol. 46, no. 6. (June 2009.): 527-540.

Lappalainen Z, Lappalainen J, Oksala NK, Laaksonen DE, Khanna S, Sen CK, Atalay M. "Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain." J Appl Physiol. Vol. 106, no. 2. (February 2009.): 461-467.

Roy S, Biswas S, Khanna S, Gordillo G, Bergdall V, Green J, Marsh CB, Gould LJ, Sen CK. "Characterization of a preclinical model of chronic ischemic wound." Physiol Genomics. Vol. 37, no. 3. (May 2009.): 211-224.

Park HA, Khanna S, Rink C, Gnyawali S, Roy S, Sen CK. "Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway." Cell Death Differ. Vol. 16, no. 8. (August 2009.): 1167-1179.

Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen CK, Khanna S.. "Oxygen-sensitive outcomes and gene expression in acute ischemic stroke." Journal of Cerebral Blood Flow and Metabolism. (February 2010.): -.

Khanna S, Parinandi NL, Kotha SR, Roy S, Rink C, Bibus D, Sen CK. "Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A and causes neuroprotection." J Neurochem. Vol. 112, no. 5. (March 2010.): 1249-1260.

Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S.. "Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice." PLoS One. Vol. 5, no. 3. (March 2010.): e9539-.

Lappalainen Z, Lappalainen J, Laaksonen DE, Oksala KJ, Khanna S, Sen CK, Atalay M. "Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes." Int J Sport Nutr Exerc Metab. Vol. 20, no. 3. (June 2010.): 206-215.

Rink C, Khanna S.. "MicroRNA in Ischemic Stroke Etiology and Pathology." Physiol Genomics. (September 2010.): -.

Roy S, Khanna S, Azad A, Schnitt R, He G, Weigert C, Ichijo H, Sen CK. "Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts." Cardiovasc Res. (April 2010.): -.

Rink C, Khanna S.. "Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke." Antioxid Redox Signal. (August 2010.): -.

Christoforidis GA, Rink C, Kontzialis MS, Mohammad Y, Koch RM, Abduljalil AM, Bergdall VK, Roy S, Khanna S, Slivka AP, Knopp MV, Sen CK. "An Endovascular Canine Middle Cerebral Artery Occlusion Model for the Study of Leptomeningeal Collateral Recruitment." Invest Radiol.. (September 2010.): -.

Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK. "Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds." Proc Natl Acad Sci U S A. Vol. 107, no. 15. (April 2010.): 6976-6981.

Sen CK, Rink C, Khanna S.. "Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease." J Am Coll Nutr. Vol. 29, no. 3 Suppl. (June 2010.): 314S-323S.

Gnyawali SC, Roy S, Driggs J, Khanna S, Ryan T, Sen CK. "High-frequency high-resolution echocardiography: first evidence on non-invasive repeated measure of myocardial strain, contractility, and mitral regurgitation in the ischemia-reperfused murine heart." J Vis Exp. Vol. 41, (July 2010.): -.

Lappalainen J, Lappalainen Z, Oksala NK, Laaksonen DE, Khanna S, Sen CK. "Atalay M. Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain." Cell Biochem Funct. (October 2010.): -.

Presentations

"[unspecified]." Presented at 1st Mtg of the Japanese Society for Tocotrienol Research, Hyogo, JP|JPN. (December 2004)

"Bioavailability of Orally Supplemented Tocotrienol in Human Tissues & Organs." Presented at 1st International Conference on Tocotrienols and Chronic Diseases, Las Vegas. (July 2010)

"Natural Vitamin E Tocotrienol Against Stroke." Presented at OSUN spring seminar series, . (May 2010)

Professional Activities

1991	19th European Congress of Cytology.
1995	International symposium and practical course on Skeletal Muscle Research. Part II.
1995	TULES-GS Course “Muscle cellular respiration, oxidative stress and damage in exercise”.
1996	Gene Transfer “Strategies for in vivo gene transfer and techniques to monitor therapeutic effects”.
1998	45th Annual meeting of the American college of sports medicine. Orlando, FL.
1999	Annual meeting of the Oxygen Club of California.
1999	Emerging Potential of Antioxidant Therapy.
2002	Experimental Biology.