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John E. Phay, MD


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410 W 10th Ave
Columbus, OH 43210

Phone: (614) 293-8550

Email: phay.1@osu.edu

 

Current OSU Appointments

Associate Professor-Clinical, Surgical Oncology

Physician, FGP-Surgical Oncology

 

Academic Advising

2012 - present Robert Plews, The Ohio State University.
 

Certifications

2004 - present American Board of Surgery: American Board of Surgery
 

Chapters in Books

Phay, John and Moley, JF. "Genetics of Cancer." In Surgery: Basic Science and Clinical Evidence. 2nd ed. Edited by Jeffrey A. Norton, Philip S. Barie, Ralph R. Bollinger, Alfred E. Chang, Stephen Lowry, Sean J. Mulvihill, Harvey I. Pass, Robert W. Thompson. 1901-1924. New York, US|USA: Springer, August 2008.

 

Clinical Services

07/01/2009 Thyroid/Neuroendocrine Tumors Clinic (The Ohio State University, Dept of Surgery)

Conferences

Broome,James,T; Schrager,Jason,J; Bilheimer,Dean; Chambers,Eugene,P; Jacobs,J,Kenneth; Phay,John. "Central venous sampling for intraoperative parathyroid hormone monitoring: are peripheral guidelines applicable?." In AMERICAN SURGEON. (July 2007). 712-716.

Zaydfudim,Victor; Stover,Daniel,G; Caro,Susan,W; Phay,John,E. "Presentation of a medullary endocrine neoplasia 2A kindred with Cushing's syndrome." In AMERICAN SURGEON. (July 2008). 659-661.

 

Degrees

1987 B.A., Williams College

1993 M.D., University of California San Francisco

 

Editorial Activities

2007 - 2010 World Journal of Surgery
2010 - 2012 Surgery
2012 - present Annals of Surgical Oncology
 

Honors

1986 Phi Beta Kappa.
1987 Sigma Xi.
1987 Cum laude.
1989 UCSF Summer Fellowship.
1991 - 1992 Howard Hughes Medical Institute Fellowship.
1997 Washington University Cancer Center Grant.
1998 - 2000 Surgical Oncology Training Grant Fellowship.
1999 Samuel A. Wells Annual Resident Research Award.
2002 - present Alpha Omega Alpha Honors Medical Society. Alpha Omega Alpha Honor Medical Society.
2002 Vanderbilt Physician Scientist Development Award.
2005 American College of Surgeons Faculty Research Fellowship.
 

Journal Articles

Phay JE, Moley JF. "Evidence for a Novel Glucose Transporter in Sarcomas." Owen H. Wangensteen Surgical Forum. (January 1998.): 416-417.

Phay JE, Rubin B. "Venous Disease." The Washington Manual of Surgery (2nd ed). (January 1999.): -.

Moley JF; Lairmore TC; Phay JE. "Hereditary endocrinopathies.." Current Problems In Surgery. Vol. 36, no. 9. (September 1999.): 653-.

Phay JE, Moley JF. "Parathyroid: Conventional Surgical Treatment." Crucial Controversies in Surgery. Vol. 3, (January 1999.): -.

Phay JE, Moley JF. "Cancer Susceptibility Genetics." Cancer Surgery for the General Surgeon. (January 1999.): -.

Phay JE; Hussain HB; Moley JF. "Strategy for identification of novel glucose transporter family members by using internet-based genomic databases.." Surgery. Vol. 128, no. 6. (December 2000.): 946-.

Phay JE; Hussain HB; Moley JF. "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).." Genomics. Vol. 66, no. 2. (June 2000.): 217-.

Phay JE; Moley JF; Lairmore TC. "Multiple endocrine neoplasias.." Seminars In Surgical Oncology. Vol. 18, no. 4. (June 2000.): 324-.

Moley JF, Phay JE. "Genetics of Cancer." Surgery: Basic Science and Clinical Evidence. (January 2001.): -.

Phay JE, Moley JF. "Hereditary Tumor Syndromes and Genetic Counseling." Washington Manual of Surgery (3rd Ed). (January 2002.): -.

Cohen MS; Phay JE; Albinson C; DeBenedetti MK; Skinner MA; Lairmore TC; Doherty GM; Balfe DM; Wells SA Jr; Moley JF. "Gastrointestinal manifestations of multiple endocrine neoplasia type 2.." Annals Of Surgery. Vol. 235, no. 5. (May 2002.): 648-.

Augustin R; Carayannopoulos MO; Dowd LO; Phay JE; Moley JF; Moley KH. "Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.." The Journal Of Biological Chemistry. Vol. 279, no. 16. (April 2004.): 16229-.

Phay,John; Ollila,David,W; Caudle,Abigail,S. "Experienced radio-guided surgery teams can successfully perform minimally invasive radio-guided parathyroidectomy without Intraoperative parathyroid hormone assays - Discussion." AMERICAN SURGEON. Vol. 72, no. 9. (September 2006.): 790-790.

Phay,John,E; Oladapupo,Sunday; Koch,Stephen; Short,Craig; Granner,Daryl; Printz,Richard,L. "Oncogenic H-Ras increases glucose metabolism with an induction of glucose transporter GLUT1 and hexokinase 2 expression." JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. Vol. 205, no. 3. (September 2007.): S89-S89.

Broome JT; Schrager JJ; Bilheimer D; Chambers EP; Jacobs JK; Phay J. "Central venous sampling for intraoperative parathyroid hormone monitoring: are peripheral guidelines applicable?." The American Surgeon. Vol. 73, no. 7. (July 2007.): 712-.

Zaydfudim V; Stover DG; Caro SW; Phay JE. "Presentation of a medullary endocrine neoplasia 2A kindred with Cushing's syndrome.." The American Surgeon. Vol. 74, no. 7. (July 2008.): 659-.

Zaydfudim V; Feurer ID; Griffin MR; Phay JE. "The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma.." Surgery. Vol. 144, no. 6. (December 2008.): 1070-.

Terhune KP; Jagasia S; Blevins LS Jr; Phay JE. "Diagnostic and therapeutic dilemmas of hypercortisolemia during pregnancy: a case report.." The American Surgeon. Vol. 75, no. 3. (March 2009.): 232-.

Phay JE; Shah MH. "Targeting RET receptor tyrosine kinase activation in cancer.." Clinical Cancer Research: An Official Journal Of The American Association For Cancer Research. Vol. 16, no. 24. (December 2010.): 5936-.

Abdel-Misih SR; Broome JT; Li X; Arrese D; Kenneth Jacobs J; Chambers EP; Phay JE. "Changing intraoperative parathyroid hormone collection sites from peripheral to central does not affect predictive accuracy during minimally invasive parathyroidectomy.." Annals Of Surgical Oncology. Vol. 18, no. 3. (March 2011.): 771-.

Caronia,Lisa,M; Phay,John,E; Shah,Manisha,H. "Role of BRAF in Thyroid Oncogenesis." CLINICAL CANCER RESEARCH. Vol. 17, no. 24. (December 2011.): 7511-7517.

Paras C, Keller M, White L, Phay J, Mahadevan-Jansen A.. "Near-infrared autoflourescence for the detection of parathyroid glands." JOURNAL OF BIOMEDICAL OPTICS. Vol. 16(6), (June 2011.): 067012-.

Kauffmann RM; Juhlin CC; Fohn LE; Broome JT; Phay JE. "Parathyroid carcinoma arising from four-gland hyperplasia.." Endocrine Practice: Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists. Vol. 17, no. 2. (March 2011.): e1-.

McWade MA, Paras C, White LM, Phay JE, Mahadeva-Jansen A, Broome JT. "A novel optical approach to intraoperative detection of parathyroid glands." Surgery. Vol. 154, no. 6. (December 2013.): 1371-7.

Yusof AM, Kothandaraman S, Zhang X, Saji M, Ringel MD, Tweedle MF, Phay JE. "Development of a calcium-sensing receptor molecular imaging agent." Surgery. Vol. 154, no. 6. (December 2013.): 1378-84.

 

Reference Works

December 2011 Ettinger DS, Agulnik M, Cates JM, Cristea M, Denlinger CS, Eaton KD, Fidias PM, Gierada D, Gockerman JP, Handorf CR, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Shulman LN, Smerage JB, Varadhachary GR, Zager JS, Zhen WK."Occult primary" PubMed - indexed for MEDLINE. : 9(12):1358
Ding H, Yusof AM, Kothandaraman S, Saji M, Wang C, Kumar K, Milum K, Carleton M, Pan X, Ringel MD, Tweedle MF, Phay JE."Localization of CaSR Antagonists in CaSR-expressing Medullary Thyroid Cancer" .
Phay J, Ringel MD."Metastatic Mechanism In Follicular Cell-derived Thyroid Cancer" .

Inventions and Patents

Anita Mahadevan-Jansen; Lisa White; John Phay; Constantine A Paras; Elizabeth Kanter Bartz; Matthew D Keller; Nicole Gasparino; Jennifer Gray Whisenant. "INTRA-OPERATIVE USE OF FLUORESCENCE SPECTROSCOPY AND APPLICATIONS OF SAME." Anasys Instruments CorporationFiled July 2009.

 

Presentations

"Increased Glucose Uptake in Colon Cancer is Mediated by the Facilitative Transporters GLUT1 and GLUT3 and the Active Transporter SGLT1.." Presented at Society of Surgical Oncology Annual Meeting, Chicago. (March 1997)

"Glut1 and Glut3 Mediate the Increased Glucose Uptake in Primary and Metastatic Colorectal Cancer and can be regulated in vitro with Antisense." Presented at American Association for Cancer Research Annual Meeting, New Orleans. (March 1998)

"Evidence for a Novel Glucose Transporter in Sarcomas." Presented at 84th Clinical Congress of the American College of Surgeons, Orlando. (October 1998)

"Glut1 Primarily Mediates the Increased Glucose Uptake in Colorectal Cancer and their Metastases and can be regulated in vitro with Antisense to Inhibit Growth." Presented at Samuel A. Wells, Jr. Resident Research Day, St Louis. (February 1999)

"Cloning of a Novel Member of the Glucose Transporter Family which is expressed in Multiple Cancers." Presented at 85th Clinical Congress of the American College of Surgeons, San Francisco. (October 1999)

"Glut1 Antisense is able to Decrease Glut1 mRNA, Glucose Uptake, and Cell Growth in a Colorectal Cancer Cell Line." Presented at FASEB summer research conference on Glucose Transporters, Snowmass, CO. (July 1999)

"Expression of a Novel Member of the Glucose Transporter Family in Multiple Cancers." Presented at American Association of Cancer Research Annual Meeting, San Francisco. (April 2000)

"Expression of an Ha-Ras mutant increases glucose metabolism in a rat intestinal epithelial cell line, RIE." Presented at American Association of Cancer Research Annual Meeting, Anaheim. (April 2005)

"Experienced radio-guided surgery teams can successfully perform minimally invasive parathyroidectomy without intraoperative parathyroid hormone assays." Presented at Southeastern Surgical Congress Annual Meeting, Orlando. (February 2006)

"Central Venous Sampling for Intra-operative PTH Monitoring: Are Peripheral Guidelines Applicable?." Presented at Southeastern Surgical Congress Annual Meeting, Charleston. (February 2007)

"Oncogenic H-Ras Increases Glucose Metabolism with an Induction of Glucose Transporter GLUT1 and Hexokinase 2 Expression." Presented at Surgical Forum of the American College of Surgeons Annual Congress, New Orleans. (October 2007)

"Diagnostic and Therapeutic Dilemmas of Hypercortisolemia in Pregnancy." Presented at American Association of Endocrine Surgeons Annual Meeting, Tucson, Arizona. (April 2007)

"Cushing’s Syndrome in MEN2A." Presented at Tennessee Chapter of the American College of Surgeons Annual Meeting, Paris Landing, Tennessee. (July 2007)

"Presentation of an MEN 2A kindred with Cushing’s syndrome." Presented at Southeastern Surgical Congress Annual Meeting, Birmingham, Alabama. (February 2008)

"Glut 1 and Hexokinase 2 Induction by Oncogenic Ras Requires both the Phosphoinositide 3-Kinase and Map Kinase Pathways." Presented at Academic Surgical Congress, Huntington Beach, California. (February 2008)

"Surgical Management of Medullary and Anaplastic Thyroid Cancer." Presented at Otolaryngology – Head and Neck Surgery Grand Rounds, Columbus, Ohio. (October 2009)

"Persistent Hypercalcemia after 3.5 Gland Removal." Presented at American Association of Endocrine Surgeons Annual Meeting, Madison, Wisconsin. (May 2009)

"Controversies in Thyroid Cancer Surgery for Residual/Recurrent Differentiated and Medullary Thyroid Cancer." Presented at Ernest L. Mazzaferri Thyroid Cancer Conference from Predisposition to Therapy: A Bench to Bedside Symposium., Columbus. (November 2010)

"Oncogenic H-Ras Effects on Glucose Transporter and Hexokinase RNA Stabilization." Presented at Academic Surgical Congress, San Antonio. (February 2010)

"Changing Intraoperative Parathyroid Hormone Collection Sites from Peripheral to Central Does Not Affect Predictive Accuracy During Parathyroidectomy." Presented at American Association of Endocrine Surgeons Annual Meeting, Pittsburg. (April 2010)

"Thyroid Nodules and the Rising Incidence of Thyroid Cancer." Presented at Grand Rounds, Portsmouth. (March 2011)

"Hypercalcemia in pregnancy." Presented at American Association of Endocrine Surgeons Annual Meeting, Houston. (April 2011)

"Real-Time Intraoperative Imaging with 99mTc Sestamibi can Reduce Time in the Operating Room during Parathyroidectomy." Presented at World Molecular Imaging Congress, Dublin, IE|IRL. (September 2012)

"Evaluation of the use of a large field-of-view (LFOV) gamma camera during intra-operative." Presented at Society of Nuclear Medicine, Miami Beach, Florida. (June 2012)

"Scientific Session V." Presented at American Association of Endocrine Surgeons Annual Meeting, Iowa City, IA, US|USA. (April 2012)

"Recurrent Pheochromocytoma During Pregnancy." Presented at American Association of Endocrine Surgeons Annual Meeting, Chicago, IL, US|USA. (April 2013)

"Development of A Calcium-Sensing Receptor Molecular Imaging Agent." Presented at American Association of Endocrine Surgeons, Chicago, IL, US|USA. (April 2013)

"A Novel Optical Approach To Intraoperative Detection of Parathyroid Glands." Presented at American Association of Endocrine Surgeons Annual Meeting, Chicago, IL, US|USA. (April 2013)

"A Novel AMPK Activator Inhibits thyroid Cancer Cell Growth." Presented at American Association of Endocrine Surgeons Annual Meeting, Chicago, IL, US|USA. (April 2013)

"A Novel AMPK Activator Inhibits thyroid Cancer Cell Growth." Presented at Columbus Surgical Society, Columbus, OH, US|USA. (March 2013)

"Kertinocyte-Directed Conditional Ablation of Dicer Imparis Wound Healing Via Induction of P21." Presented at OSU Department of Surgery Research Conference, Columbus, OH, US|USA. (May 2013)

"Intraoperative Utilization of a Portable Large Field of View Gamma Camera for Radioguided Surgery." Presented at Society of Surgical Oncology Annual Meeting, . (March 2014)

"Real-time Intraoperative Sestamibi Imaging as adjunct to Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism." Presented at 9th Annual Academic Surgical Congress, San Diego, CA, US|USA. (February 2014)

"Near Infrared Fluorescent Cholangiography Facilitates Identification of Biliary Anatomy During Laparoscopic Cholecystectomy." Presented at Department of Surgery Research Conference, Columbus, OH, US|USA. (May 2014)

"Hypocalcemia and Hemithyroidectomy." Presented at American Association of Endocrine Surgeons Annual Meeting, Boston, MA, US|USA. (April 2014)

"Intraoperative Scintigraphy Using a Large Field of View Partable Gamma Camera for Primary Hyperparathyroidism; Initial Experience." Presented at Department of Surgery Research Conference, Columbus, OH, US|USA. (May 2014)