Ohio State Navbar

Directory

Lisa D. Yee, MD


Associate Professor of Surgery
The Ohio State University
N911 Doan Hall
410 W 10th Avenue
Columbus, Ohio, 43210
Phone: 6142936654
Email: lisa.yee@osumc.edu

Degrees

September 1978 - June 1982 BA, (Summa cum laude)
September 1982 - May 1986 MD, Yale University School of Medicine

Certifications

December 1994 - Present Diplomate: Surgery, American Board of Surgery

Curriculum Development

1. Organization of the didactic conferences for third year medical students rotating on Surgical Oncology
2. Updates of lectures on "Breast Disease" for MED III students on the General Surgery rotation, including the topics of skin cancer and soft tissue sarcoma
3. Development of the Tumor Biology journal club session for medical students participating in the Honors in Surgery Program
4. Development of course material and presentations for graduate courses in Human Nutrition regarding breast cancer prevention, dietary lipids and mammary carcinogenesis

Approach to and goals in teaching

I favor teaching methods that encourage the process of gaining information and to stimulate independent and creative thinking. Teaching is conducted during inpatient rounds, operating room procedures, outpatient clinic visits and didactic sessions, using clinical scenarios to promote a problem solving approach. I like to combine interactive discussion with didactic teaching and to provide perspective on clinical medicine with incorporation of basic science research and vice versa. For the future, I will continue to improve my teaching skills based on feedback from student and peer evaluators.

Evaluation of Teaching

The evaluation information provides invaluable feedback on the quality of my teaching, allowing me to assess the impact of my methods of instruction and to incorporate changes to improve my didactic approach and presentation skills. I use the information to further develop my small group and one-on-one student teaching techniques, focusing on interactive and problem-based learning. I have also used evaluations to improve my lecture style to larger groups.

Chapters in Edited Books

1. Yee, LD, "The physiology of the breast from birth through menopause". In "The Physiologic Basis of Gynecology and Obstetrics". Baltimore: Williams & Wilkins. 2001. (Published) I wrote the chapter.

2. Yee, LD, "The principles of surgical wound healing". In "The Physiologic Basis of Gynecology and Obstetrics". Edited by:Seifer DB, Samuels P, and Kniss DA. Baltimore: Williams & Wilkins. 2001. (Published)
I wrote the chapter.

Peer-Reviewed Journal Articles

1. Murray BA, Yee LD, Loomis WF, "Immunological analysis of a glycoprotein (contact sites A) involved in intercellular adhesion of Dictyostelium discoideum". J Supramol Struct Cell Biochem. Vol. 17, no. 3: 197-211. 1981. (Published)

2. Loomis WF, Murray BA, Yee LD, Jongens T, "Adhesion-blocking antibodies prepared against gp150 react with gp80 of Dictyostelium". Exp Cell Res. Vol. 147, no. 1: 231-234. 1985. (Published)
3. Kacinski BM, Yee LD, Carter D, Li D, Kuo MT, "Human breast carcinoma cell levels of MDR-1 (P-glycoprotein) transcripts correlate in vivo inversely and reciprocally with tumor progesterone receptor content". Cancer Commun. Vol. 1, no. 1: 1-6. 1989. (Published)

4. Kacinski BM, Yee LD, Carter D, "Quantitation of tumor cell expression of the P-glycoprotein (MDR1) gene in human breast carcinoma clinical specimens". Cancer Bull. Vol. 41, no. 1: 44. 1989. (Published)

5. Yee LD, Kacinski BM, Carter D, "Oncogene structure, function and expression in breast cancer". Sem Diag Path. Vol. 6, no. 2: 110-125. 1989. (Published)

6. Guiney DG, Deiss C, Simnad B, Yee L, Pansegrau W, Lanka E, "Mutagenesis of the Tra1 core region of RK2 by using Tn5: Identification of plasmid-specific transfer genes". J Bacteriol. Vol. 171, no. 7: 4100-4103. 1989. (Published)

7. Kacinski BM, Carter D, Mittal K, Yee LD, Scata KA, Donofrio L, Chambers SK, Wang KI, Yang-Feng T, Rohrschneider LR, Rothwell VM, "Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1". Am J Path. Vol. 137, no. 1: 135-147. 1990. (Published)

8. Kacinski BM, Scata KA, Carter D, Yee LD, Sapi E, King BL, Chambers SK, Jones MA, Pirro MH, Stanley ER, Rohrschneider LR, "FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro". Oncogene. Vol. 6, no. 6: 941-952. 1991. (Published)

9. Wu K, Salas P, Yee L, Fregien N, Carraway K, "Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185neu". Oncogene. Vol. 9, 3139-3147. 1994. (Published)

10. Mesko TW, Garcia O, Yee LD, Villar MJ, Chan H, "The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a consequence of neck dissection". The Journal of Laryngology and Otology. Vol. 111, no. 5: 449-453. 1997. (Published)

11. Jain AB, Yee LD, Nalesnik MA, Youk A, Marsh G, Reyes J, Rakela J, Irish W, Fung JJ, "Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data". Transplantation. Vol. 66, no. 9: 1193-1200. 1998. (Published)

12. Yee LD, Sabourin CLK, Liu L, Smith PJ, Seewaldt V, Kniss DA, "Peroxisome proliferator-activated receptor gamma activation in human breast cancer.". International Journal of Oncology. Vol. 15, 967-973. 1999. (Published)

13. Komatsu M, Yee L, Carraway KL, "Overexpression of sialomucin complex, a rat homolog of MUC4, inhibits tumor killing by lymphokine-activated killer cells". Cancer Research. Vol. 59, 2229-2236. 1999. (Published)

14. Burak WE Jr, Walker MJ, Yee LD, Kim JA, Saha S, Hinkle G, Olsen JO, Pozderac R, Farrar WB, "Routine preoperative lymphoscintigraphy is not necessary prior to sentinel node biopsy for breast cancer". American Journal of Surgery. Vol. 177, 445-449. 1999. (Published)

15. Yee LD and Liu L, "The constitutive production of colony stimulating factor 1 by invasive human breast cancer cells". Anticancer Research. Vol. 20, 4379-4384. 2000. (Published)

16. Zervos EE, Badgwell BD, Abdessalam SF, Farrar WB, Walker MJ, Yee LD, Burak WE Jr, "Selective analysis of the sentinel node in breast cancer". Am J Surg. Vol. 182, no. 4: 372-376. 2001. (Published)

17. Dietze EC, Yee L, and Seewaldt VL, "Suppression of pRB expression in normal human mammary epithelial cells is associated with resistance to all-trans-retinoic acid but not N-(4-Hydroxylphenyl)-Retinamide". Breast Cancer Research and Treatment. Vol. 66, no. 1: 41-50. 2001. (Published)

18. Abdessalam SF, Zervos EE, Prasad M, Farrar WB, Yee LD, Walker MJ, Carson WB, Burak WE, "Predictors of positive axillary lymph nodes following sentinel lymph node biopsy in breast cancer". Am J Surg. Vol. 182, no. 4: 316-320. 2001. (Published)

19. Price-Schiavi SA, Jepson S, Li P, Arango M, Rudland PS, Yee L, Carraway KL, "Rat MUC4 (sialomucin complex) reduces binding of anti-erbB2 antibodies to tumor cell surfaces, a potential mechanism for Herceptin resistance". International Journal of Cancer. Vol. 99, no. 6: 783-791. 2002. (Published)

20. Dietze EC, Caldwell LE, Grupin SL, Marcom K, Yee L, Collins SJ, Swisshelm K, Seewaldt VL, "Retinoids and Retinoic Acid Receptors Regulate Proliferation and Apoptosis in Human Mammary Epithelial Cells and Modulate Expression of CBP/p300". Microscopy Research and Techniques. Vol. 59, no. 1: 23-40. 2002. (Published)

21. Zhu W-G, Srinivasan K, Dai Z, Duan W, Druhan LJ, Ding H, Yee L, Villalona-Calero MA, Plass C, Otterson GA, "Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter". Molecular and Cellular Biology. Vol. 23, no. 12: 4056-4065. 2003. (Published)

22. Yee LD, Guo Y, Bradbury J, Suster S, Clinton SK, Seewaldt VL, "The antiproliferative effects of PPAR gamma ligands in normal mammary epithelial cells". Breast Cancer Research and Treatment. Vol. 78, no. 2: 179-192. 2003. (Published)

23. Dietze EC, Troch MM, Bowie ML, Yee L, Bean GR, Seewaldt VL, "CBP/p300 Induction Is Required for Retinoic Acid Sensitivity in Human Mammary Cells". Biochemical and Biophysical Research Communications. Vol. 302, no. 4: 841- 848. 2003. (Published)

24. Badgwell BD, Povoski SP, Abdessalam SF, Young DC, Farrar WB, Walker MJ, Yee LD, Zervos EE, Carson WB, Burak WE, "Patterns of recurrence after sentinel lymph node biopsy for breast cancer". Annals of Surgical Oncology. Vol. 10, no. 4: 376-380. 2003. (Published)

25. Yee LD, Young DC, Rosol TJ, VanBuskirk AM, Clinton SK, "Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu- induced breast cancer in mice independently of the PPAR gamma ligand rosiglitazone". Journal of Nutrition. Vol. 135, 983-988. 2005. (Published)

26. Ramaswamy B, Povoski S, Rhoades C, Allen J, Hauger, M, Young D, Burak W, Farrar W, Yee L, Kendra K, Somasundram S, Orlowski RZ, Shapiro CL, "Phase II trial of neoadjuvant chemotherapy with docetaxel followed by epirubicin in stage II/III breast cancer". Breast Cancer Research and Treatment. Vol. 93, no. 1: 67-74. 2005. (Published)

27. Bean GR, Scott V, Yee L, Ratliff-Daniel B, Troch M, Seo P, Bowie M, Marcom PK, Slade J, Kimler B, Fabian C, Zalles CM, Broadwater G, Baker JC, Moore C, Seewaldt VL, "Retinoic Acid Receptor-beta2 Promoter Methylation in Random Periareolar Fine Needle Aspiration". Cancer Epidemiology Biomarkers and Prevention. Vol. 14, no. 4: 790-798. 2005. (Published)

28. VanBuskirk AM, Nye KJ, Lesinski G, Carson W, Yee LD, "TGF-ß Inhibition of CTL Restimulation Requires Accessory Cells and Induces Peroxisome-Proliferator Activated Receptor-gamma (PPAR gamma)". American Journal of Transplantation. Vol. 6, no. 8: 1809-1819. 2006. (Published)

29. Povoski SP, Olsen JO, Young DC, Clarke J, Burak WE, Walker MJ, Carson WE, Yee LD, Agnese DM, Pozderac RV, Hall NC, Farrar WB, "Prospective randomized clinical trial comparing intradermal, intraparenchymal, and subareolar injection routes for sentinel lymph node mapping and biopsy in breast cancer". Annals of Surgical Oncology. Vol. 13, no. 11: 1412-1421. 2006. (Published)

30. Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C, "Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers". Clinical Cancer Research. Vol. 13, no. 1: 246-252. 2007. (Published)

31. Povoski SP, Young DC, Walker MJ, Carson WE, Yee LD, Agnese DM, Farrar WB, "Re-emphasizing the concept of adequacy of intraoperative assessment of the axillary sentinel lymph nodes for identifying nodal positivity during breast cancer surgery". World Journal of Surgical Oncology. Vol. 5, 18. 2007. (Published)

32. Bean GR, Ibarra C, Goldenberg V, Baker Jr JC, Troch MM, Paisie C, Wilke LG, Yee L, Marcom PK, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Scott V, and Seewaldt VL, "Hypermethylation of the Breast Cancer-Associated Gene 1 promoter does not predict cytologic atypia or correlate with surrogate endpoints of breast cancer risk". Cancer Epidemiology Biomarkers & Prevention. Vol. 16, no. 1: 50-56. 2007. (Published)

33. Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC Jr, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL, "Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF". Clinical Cancer Research. Vol. 13, no. 22 Pt 1: 6834-6841. 2007. (Published)

34. Hatton JL, Yee LD, "Clinical use of PPAR gamma ligands in cancer". PPAR Research. Vol. 2008, 159415. 2008. (Published)

35. Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G, "Pten in stromal fibroblasts suppresses mammary epithelial tumours". Nature. Vol. 461, no. 7267: 1084-1091. 2009. (Published)

36. Ibarra-Drendall C, Wilke LG, Zalles C, Scott V, Archer LE, Lem S, Yee LD, Lester J, Kulkarni S, Murekeyisoni C, Wood M, Wilson K, Garber J, Gentry C, Stouder A, Broadwater G, Baker JC Jr, Vasilatos SN, Owens E, Rabiner S, Barron AC, Seewaldt VL, "Reproducibility of random periareolar fine needle aspiration in a multi-institutional Cancer and Leukemia Group B (CALGB) cross-sectional study". Cancer Epidemiol Biomarkers Prev. Vol. 18, no. 5: 1379-1385.
2009. (Published)

37. Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, Clinton SK, "Omega 3 fatty acid supplements in women at high risk for breast cancer show dose dependent effects on breast adipose fatty acid composition". The American Journal of Clinical Nutrition. Vol. 91, no. 5: 1185-1194. 2010. (Published)

Abstract and Short Entries

1. Yee L, Kacinski B, Carter D, Donofrio L, Eng M. "The interactions of expressed oncogenes in carcinoma of the breast". United States and Canadian Academy of Pathology Annual Meeting. Washington ( 1988 ) [ Peer-Review ] ( Published )

2. Yee LD, Liu L. "CSF-1 expression in breast cancer correlates with increased invasiveness". Association for Academic Surgery Annual Meeting Proceedings. Dallas ( 1997 ) [ Peer-Review ] ( Published )

3. Yee L, Liu L, Kniss D. "Glucocorticoid regulation of COX-2 expression in human breast cancer cells.". American Association for Cancer Research Annual Meeting Proceedings. New Orleans ( 1998 ) [ Peer-Review ] ( Published )

4. Yee L, Liu L. "CSF-1 expression in breast cancer cells correlates with increased invasiveness". Metastasis Research Society Congress Meeting. San Diego ( 1998 ) [ Peer-Review ] ( Published )

5. Yee LD, Sabourin CLK, Liu L, Smith PJ, Kniss DA. "Prostanoid activation of peroxisome proliferator-activated receptor gamma inhibits breast cancer cell proliferation". American Association for Cancer Research Annual Meeting Proceedings. Philadelphia ( 1999 ) [ Peer-Review ] ( Published )

6. Yee LD. "NCCN Practice Guidelines for Patient/Physician Communication: Informed Consent". Fort Lauderdale ( 2000 ) [ Peer-Review ] ( Published )

7. Yee LD, Liu L, Sabourin CLK. "Differential activation of peroxisome proliferator-activated receptor gamma (PPAR) in human breast cancer by synthetic and natural ligands.". American Association for Cancer Research Annual Meeting Proceedings. San Francisco ( 2000 ) [ Peer-Review ] ( Published )

8. Yee LD. "Activation of peroxisome proliferator activated receptor gamma in human breast cancer". 5th World Congress on Advances in Oncology Proceedings. Crete ( 2000 ) [ Peer-Review ] ( Published )

9. Yee LD, Bradbury J, Liu L, Seewaldt V, Clinton S. "The expression and activation of peroxisome proliferator-activated receptor gamma (PPAR) in normal and malignant mammary epithelial cells". American Association for Cancer Research Annual Meeting Proceedings. New Orleans ( 2001 ) [ Peer-Review ] ( Published )

10. Beckman N, Guo Y, Yee LD. "Inhibition of human breast cancer cell proliferation by PPAR and RXR ligands".
American Association of Cancer Research Annual Meeting Proceedings. San Francisco ( 2002 ) [ Peer-Review ] ( Published )

11. Yee LD, Cheung S, Eng C. "Rosiglitazone therapy in breast cancer, Era of Hope Department of Defense". Era of Hope Department of Defense Breast Cancer Research Program Proceedings. Orlando ( 2002 ) [ Peer-Review ] ( Published )

12. Yee LD, Guo Y, Suster S, Clinton SK, Seewaldt VL. "The antiproliferative effects of PPARg ligands in normal mammary epithelial cells". Frontiers in Cancer Prevention Research Annual Meeting Proceedings. Boston ( 2002 ) [ Peer-Review ] ( Published )

13. Dittmar P, VanBuskirk A, Yee LD. "The antiangiogenic effects of PPAR ligands on EOMA endothelial cells". American Association for Cancer Research Annual Meeting Proceedings. Washington ( 2003 ) [ Peer-Review ] ( Published )

14. Troch MM, Bean G, Scott V, Ratliff B, Kimler B, Fabian C, Zalles CM, Yee L, Seewaldt VL. "Can RARbeta p2 promoter methylation in breast random periareolar fine-needle aspiration serve to risk stratify women at high risk for breast cancer?". Association for Cancer Research Annual Meeting Proceedings. ( 2004 ) [ Peer-Review ] ( Published )

15. Xu RX, Qiang B, Olsen JO, Povoski SP, Yee LD, Mao J. "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging". IEEE Eng Med Biol. 2005 ed. Vol. 1385, (2005 ): 4473-4476. [ Peer-Review ] ( Published )

16. Yee LD, Young DC, Rosol TJ, VanBuskirk AM, Clinton SK. "Dietary n 3 polyunsaturated fatty acids inhibit HER 2/neu induced breast cancer in mice independently of the PPAR ligand rosiglitazone,". American Association for Cancer Research Annual Meeting Proceedings. Anaheim ( 2005 ) [ Peer-Review ] ( Published )

17. Vanbuskirk A, Nye KJ, Lesinski G, Yee LD, Carson WE. "A role for antigen presenting cells (APC) in post-transplant lymphoproliferative disorder (PTLD)". American Transplant Congress. ( 2005 ) [ Peer-Review ] ( Published )

18. Yee LD, Williams N, Wen P, Suster S, Farrar W, Walker M, Povoski S, Eng C. "Rosiglitazone therapy in breast cancer". Era of Hope Department of Defense Breast Cancer Research Meeting Proceedings. Philadelphia ( 2005 ) [ Peer- Review ] ( Published )

19. Seo PH, Bean GR, Baker Jr. JC, Scott JV, Rasheed K, Yee LD, Troch MM, Case N, Bowie ML, Marcom PK, Kimler BF, Zalles CM, Sloane R, Fabian CJ, Seewaldt VL. "Association of RAR 2, ER, BRCA and p16 promoter methylation with cytologic atypia in random periareolar fine needle aspiration (RPFNA) breast tissue of asymptomatic women at high risk for breast cancer". San Antonio Breast Cancer Symposium Proceedings. San Antonio ( 2005 ) [ Peer-Review ] ( Published )

20. Yee LD, Williams N, Wen P, Young DC, Lester J, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C.. "The effects of rosiglitazone therapy in early stage breast cancer". Association for Cancer Research Annual Meeting Proceedings. Washington ( 2006 ) [ Peer-Review ] ( Published )

21. Hatton JL, Zhou W, Nye K, Shrode G, Belury MA, Oberyszyn TM, VanBuskirk AM, Yee LD,. "Dietary fish oil increases UVB-induced neutrophil infiltration and activation in the skin but inhibits edema". Association for Cancer Research Annual Meeting Proceedings. Washington ( 2006 ) [ Peer-Review ] ( Published )

22. Yee LD, Evans J, Hatton J, Rosol TJ, Lehman A, Clinton SK. "n-3 and n-6 PUFA-mediated modulation of HER-2/neu membrane localization and signaling in breast cancer". Frontiers in Cancer Prevention Annual Meeting Proceedings. Philadelphia ( 2007 ) [ Peer-Review ] ( Published )

23. Yee LD, Lester JL, Cole RM, Richardson JR, Li Y, Hsu JC, Belury MA, Clinton SK. "A dose response study of omega 3 fatty acids in women at high risk for breast cancer". Association for Cancer Research Annual Meeting Proceedings. Denver ( 2009 ) [ Peer-Review ] ( Published )

24. Weng SC, Wu, E, Kulp, S, Wang, DS, Chen CS, Yee LD. "The antitumor effects of OSU-HDAC42, a histone deacetylase inhibitor, in HER2-positive breast cancer are mediated partly through Hsp90 modulation". Association for Cancer Research Annual Meeting Proceedings. Denver ( 2009 ) [ Peer-Review ] ( Published )

Invited Presentations

Local

1. Lisa D. Yee, Presenter. "Cancer Prevention." Presented at Surgical Grand Rounds. Columbus, Ohio, ( 2002 )

2. Lisa D. Yee, Presenter. "Management of High Risk Breast Patients." Presented at Department of Obstetrics and
Gynecology Grand Rounds. Columbus, Ohio, ( 2003 )

3. Lisa D. Yee, Lecturer. "Management of Menopausal Symptoms in Women at High Risk and in Breast Cancer Survivors." Presented at Breast Cancer Risk: Emerging Issues and Strategies for Patient Management. Columbus, Ohio, ( 2004 )

4. Lisa D. Yee, Lecturer. "Surgical Management of Breast Cancer." Presented at Hematology-Oncology Fellowship Lecture Series. Columbus, Ohio, ( 2004 )

5. Lisa D. Yee, Seminar Presenter. "PPARgamma, fatty acids, and breast cancer prevention." Presented at Ohio State University Nutrition Seminar. Columbus, Ohio, ( 2005 )

6. Lisa D. Yee, Presenter. "Breast Cancer Prevention." Presented at Surgical Grand Rounds. Columbus, Ohio, ( 2008 )

7. Lisa D. Yee, Presenter. "Omega 3 fatty acids and breast cancer – a “neu” perspective." Presented at Center for
Advanced Functional Foods Research and Entrepreneurship Seminar. Columbus, Ohio, United States. ( 2010 )

8. Lisa D. Yee, Seminar Presenter. "Of mice and women: omega 3 fatty acids for breast cancer prevention." Presented at 7th Annual Russell Klein Nutrition Research Symposium. Columbus, Ohio, United States. ( 2010 )

National

1. Lisa D. Yee, Panelist. "Physical & Psycho-social Issues after Breast Cancer Diagnosis: Hormones, Fertility, Menopause." Presented at Delivering the Promise, 6th Annual Mission Conference of the Susan G. Komen Breast Cancer Foundation. Washington, D.C., ( 2003 )

2. Lisa D. Yee, Seminar Presenter. "PPARs, fatty acids and breast cancer." Presented at Breast Research Round Table. Kansas City, Kansas, ( 2003 )

Other Presentations

Local

1. Lisa D. Yee, Presenter. "Polyunsaturated fatty acids and breast cancer prevention: bridging the gap between mice and women." Presented at Roswell Park Cancer Institute Prevention Grand Rounds. Buffalo, New York, United States. (2009 ) Joint presentation with Dr. Martha A. Belury

Focus of Research

The Yee laboratory is interested in gene-nutrient interactions in breast cancer that affect the development and progression of breast cancer. One major area of research involves investigation of the mechanisms by which dietary fat content, specifically omega 3 and omega 6 polyunsaturated fatty acids, affects HER-2/neu signal transduction in mammary carcinogenesis. A second area of research is the establishment of novel biomarkers to monitor breast cancer risk and the effects of chemopreventive and/or bioactive nutrients such as dietary omega 3 fatty acids in high risk cohorts. A third area of interest is the role of the steroid nuclear receptor peroxisome proliferator activated receptor gamma (PPAR) in mediating dietary fat effects in mammary carcinogenesis, which may affect proliferative, angiogenic and inflammatory responses critical to breast cancer. We work closely with the research groups of Drs. Steven Clinton, Professor, Department of Internal Medicine and Martha Belury, Professor, Department of Human Nutrition.

I am also collaborating with other OSU investigators on breast cancer related projects, including Drs. Michael C. Ostrowski, Professor & Chair, Department of Molecular and Cellular Biochemistry (stromal-epithelial cell interactions in the mammary tumor microenvironment), Timothy Huang, Professor, Department of Molecular Virology, Immunology & Medical Genetics (DNA methylation and gene expression studies in women at high risk for breast cancer), Mette Prætorius Ibba, Assistant Professor, Department of Molecular and Cellular Biochemistry (dietary effects on autophagy in breast cancer), Zhongfa Liu, Research Assistant Professor, Department of Pharmacology (curcumin and omega 3 fatty acid modulation of DNA methylation and gene expression in breast cancer), Ronald Glaser, Professor, Institute of Behavioral Medicine Research (omega 3 fatty acids and stress hormone response in nasopharyngeal cancer), Douglas Kniss, Professor, Department of Obstetrics/Gynecology (ferlin and breast cancer invasion and metastasis).

My translational and clinical research is focused on breast cancer prevention and survivorship, with an emphasis on dietary interventions. I serve as the Breast Surgery Co-Chair for CALGB 70305, A randomized study to prevent lymphedema in women treated for breast cancer (PI: Electra Paskett, PhD) and site PI for two multi-institutional trials for women at high risk of developing breast cancer utilizing random periareolar fine needle aspiration of the breast for biomarker development (Testing for the Reproducibility of Reverse Phase Proteomic Proteomic Signatures in Random Periareolar Fine Needle Aspiration (RPFNA) Cytology, PI: Victoria Seewaldt, Duke University) and biomarkers of response to chemopreventive measures (OSU protocol 2009C0018, Breast cancer prevention by letrozole in high risk women, PI: Carol Fabian, MD, University of Kansas). I am conducting a pilot trial of dietary fish in high risk women, with funding from the National Fisheries Scholarship Fund (OSU protocol 10024, Omega 3 fatty acids and breast cancer prevention-protective benefits of increased fish consumption, PI: Lisa Yee). Pending protocols that have received funding for which I am Co-PI include 1) Prevention of Aromatase Inhibitor-induced Joint Symptoms with Omega 3 Fatty Acid Supplementation: a randomized placebo controlled pilot study, CALGB CCOP Research grant, PI: Maryam Lustberg and for which I am the site PI for OSU: 2) Vitamin D and breast cancer biomarkers, NIH/NCI, PI: Marie Wood, University of Vermont; 3) Flaxseed Lignan as a Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer, Susan G. Komen Foundation Promise Grant, PI: Carol Fabian, University of Kansas.

Research Funding

1. Date Submitted: 07/2009. PTEN in the tumor microenvironment of breast cancer. ( 0 ) Research Grant. ( Pending )

2. Date Submitted: 05/2010. Ferlin protein expression and function in breast cancer cell motility and metastasis. ( 0 ) Research Grant. ( Pending )
PI: Douglas Kniss

3. Date Submitted: 10/2010. Potential breast cancer risk from bioactive Zeranol metabolites in beef. ( 0 ) Research Grant. ( Pending )
PI: Young C. Lin

4. Date Submitted: 07/2004 - Date Denied: 07/2004. IFN-g, TGF-b, PTLD: The pathway balance model.. National Institutes of Health. ( 0 ) Research Grant. ( Unfunded )

5. Date Submitted: 09/2005 - Date Denied: 09/2005. The effects of dietary n-3 fatty acids on mammary carcinogenesis and immune function. ( 0 ) Research Grant. ( Unfunded )

6. Date Submitted: 04/2006 - Date Denied: 04/2006. Multimodality strategies to assess short term breast cancer risk and response to chemoprevention. ( 0 ) Research Grant. ( Unfunded )

7. Date Submitted: 09/2006 - Date Denied: 09/2006. Toll-like receptors, fatty acids, and breast cancer prevention. ( 0 ) Research Grant. ( Unfunded )

8. Date Submitted: 07/2007 - Date Denied: 07/2007. Omega 3 fatty acids for breast cancer prevention in high risk women. ( 0 ) Research Grant. ( Unfunded )

9. Date Submitted: 07/2007 - Date Denied: 07/2007. Dietary omega-3 fatty acids and macrophage-mediated immune response in breast carcinogenesis. ( 0 ) Research Grant. ( Unfunded )

10. Date Submitted: 09/2007 - Date Denied: 09/2007. Energy balance and immune cell function in mammary carcinogenesis. ( 0 ) Research Grant. ( Unfunded )

11. Date Submitted: 09/2007 - Date Denied: 09/2007. Breast adipose and cancer risk: biomarkers of inflammation and dietary response. ( 0 ) Research Grant. ( Unfunded )

12. Date Submitted: 10/2008 - Date Denied: 10/2008. Novel breast cancer drug based on diketo curcumin scaffold targeting STAT3. American Association for Cancer Research. ( 0 ) Research Grant. ( Unfunded )

13. Date Submitted: 01/2009 - Date Denied: 01/2009. Empowering breast cancer patients? treatment decisions using Oncotype DX. ( 0 ) Research Grant. ( Unfunded )

14. Date Submitted: 02/2009 - Date Denied: 02/2009. Developing novel drugs via small molecule STAT3 inhibition for breast cancer therapy. ( 0 ) Research Grant. ( Unfunded )

15. Date Submitted: 03/2009. ( 0 ) Research Grant. ( Unfunded )

16. Date Submitted: 06/2009. (ARRA) Pharmacokinetics and bioavailability of standard and self-microemulsion curcumin. (0 ) Research Grant. ( Unfunded )

17. Date Submitted: 07/2009. The role of dickkopf-1 (DKK1) in breast cancer bone metastases.. ( 0 ) Research Grant. ( Unfunded )

18. Date Submitted: 09/2009. A randomized study to prevent lymphedema in women treated for breast cancer. National Institutes of Health. ( 0 ) Research Grant. ( Unfunded )

19. Date Submitted: 12/2009. Helping breast cancer patients make treatment decisions using genomic tests. ( 0 ) Research Grant. ( Unfunded )

20. Date Submitted: 01/2010. The role of Dickkopf-1 (DKK1) in breast cancer bone metastases. ( 0 ) Research Grant. ( Unfunded )

Service

Ad hoc Reviewer

2003 Journal of Medical Genetics.
2005 Cancer Letters.
2006 Antioxidants and Redox Signaling.
2007 Clinical Breast Cancer.
2007 Biomed Central.
2008 PPAR Research.
2010 Clinical Nutrition.
2002 Cancer Research.
2002 American Journal of Obstetrics and Gynecology.
2010 Experimental Biology and Medicine.

Service to Professional Societies

2008 - Present. Member. Breast Cancer Local Regional and Adjuvant Therapy Track,
Present Member. American Society of Clinical Oncology,
Present Member. American Medical Association,
Present Member. American Association for Cancer Research,

Consultation Activity

1999 - 2003 Member of task force, NCCN Patient/Physician Communication Task Force, National Comprehensive Cancer Network, Key Achievement: Chairperson for the Discussing Clinical Trials Subcommittee

Clinical Services

Medical

2000 - Present OSU-0115, Rosiglitazone Therapy for Breast Cancer. The Ohio State University, The
James Cancer Hospital. Description: Principal Investigator

2000 - Present OSU-9990, Fatty Acids & Peroxisome Proliferator-Activated Receptors in Breast Cancer
Prevention. The Ohio State University, The James Cancer Hospital. Description: Principal Investigator

2003 - Present The Ohio State University, The James Cancer Hospital.
Description: Principal Investigator

2006 - Present The Ohio State University, The James Cancer Hospital.
Description: Principal Investigator

2007 - Present CALGB-70305, A Randomized Study to Prevent Lymphedema in Women Treated for
Breast Cancer. The Ohio State University, The James Cancer Hospital. Description: Site Principal Investigator, CALGB Breast Surgery Co-Chairperson

2009 - Present OSU-08189, Breast Cancer Prevention by Letrozole in High Risk Women. The Ohio State
University, The James Cancer Hospital. Description: Site Principal Investigator

2010 - Present The Ohio State University, The James Cancer Hospital.
Description: Principal Investigator

2010 - Present The Ohio State University, The James Cancer Hospital.
Description: Site Principal Investigator

Present. Surgical Oncology Service. The Ohio State Medical Center, James Cancer Hospital, Surgery.

Present. Surgical Oncology Clinic. James Care in Dublin, The James Cancer Hospital, Surgery.

Present. High Risk Breast Clinic. James Care in Dublin, The James Cancer Hospital, Surgery.

Community Service

2003 Volunteer, Medical Reviewer, Susan G. Komen Breast Cancer Foundation, Washington, D.C.,
Key Achievement: reviewed and edited articles written about breast cancer-related topics covered at the AACR meeting

2003 - 2004 Volunteer, Advisory Committee, The Ribbon: Advice for Life after Breast Cancer, Columbus, Ohio.

2002 - Present Volunteer, Living with Lymphedema: A Comprehensive Care Model, The James Cancer Hospital, Columbus Affiliate of the Susan G. Komen Breast Cancer Foundation, Columbus, Ohio.
Key Achievement: invited speaker to present "Diagnosing and Treating Lymphedema"

2007 - Present Volunteer, Ladies Night Out: Breast cancer detection-risk factors, screening, and prevention, Mercer Health, Celina, Ohio.

2010 - Present Volunteer, It's All About Health, The Cancer Screening Controversy, Joy 106.3 FM, Columbus, Ohio.

Research

2000 - 2009 Grant Reviewer, Susan G. Komen Breast Cancer Foundation,
2004 - Present Grant Reviewer, Department of Defense Breast Cancer Research Program,
2011 - Present Grant Reviewer, World Cancer Research Foundation Grant Program, World Cancer
Research Foundation,

Conference Participation

2009 - Present Moderator, Breast Cancer Local Regional and Adjuvant Therapy Track, Oral Presentation
Session, Annual Meeting, American Society of Clinical Oncology, Orlando, Florida.

2010 - Present Moderator, Breast Cancer Local Regional and Adjuvant Therapy Track, Poster Discussion
Session, Annual Meeting, American Society of Clinical Oncology, Chicago, Illinois.

Administrative Service

The Ohio State University

1997 - 2000 Information Systems Committee, Member
2001 - 2002 Undergraduate Curriculum Committee, Member
2002 - 2010 Roessler Medical Student Scholarship Committee, Reviewer
2003 - 2010 Animal Review Committee, Member
1996 - 2010 Comprehensive Cancer Center, Molecular Carcinogenesis and Chemoprevention,
Member
2002 - 2010 Cancer Institutional Review Board, Member
2006 - 2010 Cancer Institutional Review Board, Expedited Review Panel, Active Member
2009 - 2010 Food Innovation Center, Faculty Member

Participation in Student Life programs

My involvement in Student Life programs includes presentations to undergraduate students in Animal Sciences and Human Nutrition regarding career choices and basic/clinical research. I have also served as a judge for poster presentations at annual meetings of The Ohio State University-Comprehensive Cancer Center and Russell Klein Nutrition Research Seminar of the OSU Graduate Society of Nutritional Sciences. I have participated in mentoring programs for incoming Freshman minority students and undergraduate women interested in surgery.

Service activities

My professional service activities are primarily in the areas of grant, manuscript and protocol review: 1) grant review as a scientific reviewer (Susan G. Komen Foundation, Department of Defense Breast Cancer Research Program); 2) manuscript review as an ad hoc reviewer (journals in the areas of cancer biology, breast cancer, and diet and cancer); 3) protocol review as a longstanding member of the Cancer Institutional Review Board and expedited review panel for the Cancer IRB. In addition to involvement on other University committees on a shorter term basis, I have been a longstanding member of the Licensed Independent Health Care Provider committee. Clinical service includes my activities as an attending physician on the Scarlet service of Surgical Oncology with weekly breast surgical oncology clinics, every other monthly high risk breast clinics, on call duties 24 hours per day and inpatient consultation services on a rotating basis every several weeks. I have also served as a presenter or moderator for community-based, local and national/international meetings for topics in breast cancer treatment and prevention and survivorship issues.