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Lisa D. Yee, MD

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410 W 10th Ave
Columbus, OH 43210

Phone: (614) 293-6654

Email: yee.52@osu.edu


Current OSU Appointments

Associate Professor-Clinical, Surgical Oncology

Physician, FGP-Surgical Oncology



1994 - present Diplomate: American Board of Surgery


Xu,Ronald,X; Qiang,Bo; Olsen,John,O; Povoski,Stephen,P; Yee,Lisa,D; Mao,Jimmy. "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging." 2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7. (January 2005). 4473-4476.



1986 M.D., Yale University School of Medicine


Editorial Activities

2010 - present Experimental Biology and Medicine

Journal Articles

Murray BA, Yee LD, Loomis WF. "Immunological analysis of a glycoprotein (contact sites A) involved in intercellular adhesion of Dictyostelium discoideum." J Supramol Struct Cell Biochem. Vol. 17, no. 3. (January 1981.): 197-211.

Loomis WF, Murray BA, Yee LD, Jongens T. "Adhesion-blocking antibodies prepared against gp150 react with gp80 of Dictyostelium." Exp Cell Res. Vol. 147, no. 1. (August 1985.): 231-234.

Yee LD, Kacinski BM, Carter D. "Oncogene structure, function and expression in breast cancer." Sem Diag Path. Vol. 6, no. 2. (May 1989.): 110-125.

Kacinski BM, Yee LD, Carter D, Li D, Kuo MT. "Human breast carcinoma cell levels of MDR-1 (P-glycoprotein) transcripts correlate in vivo inversely and reciprocally with tumor progesterone receptor content." Cancer Commun. Vol. 1, no. 1. (January 1989.): 1-6.

Kacinski BM, Yee LD, Carter D. "Quantitation of tumor cell expression of the P-glycoprotein (MDR1) gene in human breast carcinoma clinical specimens." Cancer Bull. Vol. 41, no. 1. (January 1989.): 44-.

Guiney DG, Deiss C, Simnad B, Yee L, Pansegrau W, Lanka E. "Mutagenesis of the Tra1 core region of RK2 by using Tn5: Identification of plasmid-specific transfer genes." J Bacteriol. Vol. 171, no. 7. (July 1989.): 4100-4103.

Kacinski BM, Carter D, Mittal K, Yee LD, Scata KA, Donofrio L, Chambers SK, Wang KI, Yang-Feng T, Rohrschneider LR, Rothwell VM. "Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1." Am J Path. Vol. 137, no. 1. (July 1990.): 135-147.

Kacinski BM, Scata KA, Carter D, Yee LD, Sapi E, King BL, Chambers SK, Jones MA, Pirro MH, Stanley ER, Rohrschneider LR. "FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro." Oncogene. Vol. 6, no. 6. (June 1991.): 941-952.

Wu K, Salas P, Yee L, Fregien N, Carraway K. "Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185neu." Oncogene. Vol. 9, (January 1994.): 3139-3147.

Mesko TW, Garcia O, Yee LD, Villar MJ, Chan H. "The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a consequence of neck dissection." The Journal of Laryngology and Otology. Vol. 111, no. 5. (January 1997.): 449-453.

Jain AB, Yee LD, Nalesnik MA, Youk A, Marsh G, Reyes J, Rakela J, Irish W, Fung JJ. "Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data." Transplantation. Vol. 66, no. 9. (January 1998.): 1193-1200.

Yee LD, Sabourin CLK, Liu L, Smith PJ, Seewaldt V, Kniss DA. "Peroxisome proliferator-activated receptor gamma activation in human breast cancer.." International Journal of Oncology. Vol. 15, (January 1999.): 967-973.

Burak WE Jr, Walker MJ, Yee LD, Kim JA, Saha S, Hinkle G, Olsen JO, Pozderac R, Farrar WB. "Routine preoperative lymphoscintigraphy is not necessary prior to sentinel node biopsy for breast cancer." American Journal of Surgery. Vol. 177, (January 1999.): 445-449.

Komatsu M, Yee L, Carraway KL. "Overexpression of sialomucin complex, a rat homolog of MUC4, inhibits tumor killing by lymphokine-activated killer cells." Cancer Research. Vol. 59, (January 1999.): 2229-2236.

Yee LD and Liu L. "The constitutive production of colony stimulating factor 1 by invasive human breast cancer cells." Anticancer Research. Vol. 20, (January 2000.): 4379-4384.

Zervos EE, Badgwell BD, Abdessalam SF, Farrar WB, Walker MJ, Yee LD, Burak WE Jr. "Selective analysis of the sentinel node in breast cancer." Am J Surg. Vol. 182, no. 4. (January 2001.): 372-376.

Abdessalam SF, Zervos EE, Prasad M, Farrar WB, Yee LD, Walker MJ, Carson WB, Burak WE. "Predictors of positive axillary lymph nodes following sentinel lymph node biopsy in breast cancer." Am J Surg. Vol. 182, no. 4. (January 2001.): 316-320.

Dietze EC, Yee L, and Seewaldt VL. "Suppression of pRB expression in normal human mammary epithelial cells is associated with resistance to all-trans-retinoic acid but not N-(4-Hydroxylphenyl)-Retinamide." Breast Cancer Research and Treatment. Vol. 66, no. 1. (January 2001.): 41-50.

Dietze EC, Caldwell LE, Grupin SL, Marcom K, Yee L, Collins SJ, Swisshelm K, Seewaldt VL. "Retinoids and Retinoic Acid Receptors Regulate Proliferation and Apoptosis in Human Mammary Epithelial Cells and Modulate Expression of CBP/p300." Microscopy Research and Techniques. Vol. 59, no. 1. (January 2002.): 23-40.

Price-Schiavi SA, Jepson S, Li P, Arango M, Rudland PS, Yee L, Carraway KL. "Rat MUC4 (sialomucin complex) reduces binding of anti-erbB2 antibodies to tumor cell surfaces, a potential mechanism for Herceptin resistance." International Journal of Cancer. Vol. 99, no. 6. (January 2002.): 783-791.

Badgwell BD, Povoski SP, Abdessalam SF, Young DC, Farrar WB, Walker MJ, Yee LD, Zervos EE, Carson WB, Burak WE. "Patterns of recurrence after sentinel lymph node biopsy for breast cancer." Annals of Surgical Oncology. Vol. 10, no. 4. (January 2003.): 376-380.

Zhu W-G, Srinivasan K, Dai Z, Duan W, Druhan LJ, Ding H, Yee L, Villalona-Calero MA, Plass C, Otterson GA. "Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter." Molecular and Cellular Biology. Vol. 23, no. 12. (January 2003.): 4056-4065.

Dietze EC, Troch MM, Bowie ML, Yee L, Bean GR, Seewaldt VL. "CBP/p300 Induction Is Required for Retinoic Acid Sensitivity in Human Mammary Cells." Biochemical and Biophysical Research Communications. Vol. 302, no. 4. (January 2003.): 841-848.

Yee LD, Guo Y, Bradbury J, Suster S, Clinton SK, Seewaldt VL. "The antiproliferative effects of PPAR gamma ligands in normal mammary epithelial cells." Breast Cancer Research and Treatment. Vol. 78, no. 2. (January 2003.): 179-192.

Ramaswamy B, Povoski S, Rhoades C, Allen J, Hauger, M, Young D, Burak W, Farrar W, Yee L, Kendra K, Somasundram S, Orlowski RZ, Shapiro CL. "Phase II trial of neoadjuvant chemotherapy with docetaxel followed by epirubicin in stage II/III breast cancer." Breast Cancer Research and Treatment. Vol. 93, no. 1. (January 2005.): 67-74.

Yee LD, Young DC, Rosol TJ, VanBuskirk AM, Clinton SK. "Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPAR gamma ligand rosiglitazone." Journal of Nutrition. Vol. 135, (January 2005.): 983-988.

Bean GR, Scott V, Yee L, Ratliff-Daniel B, Troch M, Seo P, Bowie M, Marcom PK, Slade J, Kimler B, Fabian C, Zalles CM, Broadwater G, Baker JC, Moore C, Seewaldt VL. "Retinoic Acid Receptor-beta2 Promoter Methylation in Random Periareolar Fine Needle Aspiration." Cancer Epidemiology Biomarkers and Prevention. Vol. 14, no. 4. (January 2005.): 790-798.

VanBuskirk AM, Nye KJ, Lesinski G, Carson W, Yee LD. "TGF-ß Inhibition of CTL Restimulation Requires Accessory Cells and Induces Peroxisome-Proliferator Activated Receptor-gamma (PPAR gamma)." American Journal of Transplantation. Vol. 6, no. 8. (January 2006.): 1809-1819.

Povoski SP, Olsen JO, Young DC, Clarke J, Burak WE, Walker MJ, Carson WE, Yee LD, Agnese DM, Pozderac RV, Hall NC, Farrar WB. "Prospective randomized clinical trial comparing intradermal, intraparenchymal, and subareolar injection routes for sentinel lymph node mapping and biopsy in breast cancer." Annals of Surgical Oncology. Vol. 13, no. 11. (January 2006.): 1412-1421.

Bean GR, Ibarra C, Goldenberg V, Baker Jr JC, Troch MM, Paisie C, Wilke LG, Yee L, Marcom PK, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Scott V, and Seewaldt VL. "Hypermethylation of the Breast Cancer-Associated Gene 1 promoter does not predict cytologic atypia or correlate with surrogate endpoints of breast cancer risk." Cancer Epidemiology Biomarkers & Prevention. Vol. 16, no. 1. (January 2007.): 50-56.

Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC Jr, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL. "Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF." Clinical Cancer Research. Vol. 13, no. 22 Pt 1. (January 2007.): 6834-6841.

Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C. "Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers." Clinical Cancer Research. Vol. 13, no. 1. (January 2007.): 246-252.

Povoski SP, Young DC, Walker MJ, Carson WE, Yee LD, Agnese DM, Farrar WB. "Re-emphasizing the concept of adequacy of intraoperative assessment of the axillary sentinel lymph nodes for identifying nodal positivity during breast cancer surgery." World Journal of Surgical Oncology. Vol. 5, (January 2007.): 18-.

Hatton JL, Yee LD. "Clinical use of PPAR gamma ligands in cancer." PPAR Research. Vol. 2008, (January 2008.): 159415-.

Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G. "Pten in stromal fibroblasts suppresses mammary epithelial tumours." Nature. Vol. 461, no. 7267. (January 2009.): 1084-1091.

Ibarra-Drendall C, Wilke LG, Zalles C, Scott V, Archer LE, Lem S, Yee LD, Lester J, Kulkarni S, Murekeyisoni C, Wood M, Wilson K, Garber J, Gentry C, Stouder A, Broadwater G, Baker JC Jr, Vasilatos SN, Owens E, Rabiner S, Barron AC, Seewaldt VL. "Reproducibility of random periareolar fine needle aspiration in a multi-institutional Cancer and Leukemia Group B (CALGB) cross-sectional study." Cancer Epidemiol Biomarkers Prev. Vol. 18, no. 5. (May 2009.): 1379-1385.

Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, Clinton SK. "Omega 3 fatty acid supplements in women at high risk for breast cancer show dose dependent effects on breast adipose fatty acid composition." The American Journal of Clinical Nutrition. Vol. 91, no. 5. (May 2010.): 1185-1194.

Zhongfa,Liu; Chiu,Ming; Wang,Jiang; Chen,Wei; Yen,Winston; Fan-Havard,Patty; Yee,Lisa,D; Chan,Kenneth,K. "Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice.." Cancer chemotherapy and pharmacology. Vol. 69, no. 3. (March 2012.): 679-689.

Chen,Wei; Fan-Havard,Patty; Yee,Lisa,D; Cao,Yu; Stoner,Gary,D; Chan,Kenneth,K; Liu,Zhongfa. "A liquid chromatography-tandem mass spectrometric method for quantification of curcumin-O-glucuronide and curcumin in human plasma." JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. Vol. 900, (July 2012.): 89-93.

D'Amato,Nicholas,C; Ostrander,Julie,H; Bowie,Michelle,L; Sistrunk,Christopher; Borowsky,Alexander; Cardiff,Robert,D; Bell,Katie; Young,Lawrence,JT; Simin,Karl; Bachelder,Robin,E; Delrow,Jeff; Dawson,Alyssa; Yee,Lisa,D; Mrozek,Krzysztof; Clay,Timothy,M; Osada,Takuya; Seewaldt,Victoria,L. "Evidence for Phenotypic Plasticity in Aggressive Triple-Negative Breast Cancer: Human Biology Is Recapitulated by a Novel Model System." PLOS ONE. Vol. 7, no. 9. (September 2012.): e45684-.

Fagundes,Christopher,P; Bennett,Jeanette,M; Alfano,Catherine,M; Glaser,Ronald; Povoski,Stephen,P; Lipari,Adele,M; Agnese,Doreen,M; Yee,Lisa,D; Carson,William,E; Farrar,William,B; Malarkey,William,B; Chen,Min; Kiecolt-Glaser,Janice,K. "Social Support and Socioeconomic Status Interact to Predict Epstein-Barr Virus Latency in Women Awaiting Diagnosis or Newly Diagnosed With Breast Cancer." HEALTH PSYCHOLOGY. Vol. 31, no. 1. (January 2012.): 11-19.

Liu Zhongfa,Z,F; Chiu,Ming; Wang,Jiang; Chen,Wei; Yen,Winston; Fan-Havard,Patty; Yee,Lisa,D; Chan,Kenneth,K. "Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice." CANCER CHEMOTHERAPY AND PHARMACOLOGY. Vol. 69, no. 3. (March 2012.): 679-689.

Fagundes,Christopher,P; Glaser,Ronald; Alfano,Catherine,M; Bennett,Jeanette,M; Povoski,Stephen,P; Lipari,Adele,M; Agnese,Doreen,M; Yee,Lisa,D; Carson,William,E; Farrar,William,B; Malarkey,William,B; Kiecolt-Glaser,Janice,K. "Fatigue and herpesvirus latency in women newly diagnosed with breast cancer." BRAIN BEHAVIOR AND IMMUNITY. Vol. 26, no. 3. (March 2012.): 394-400.

Lester,Joanne; Yee,Lisa,Diane. "Random periareolar fine-needle aspiration: the new pap smear of the breast?." Journal of the advanced practitioner in oncology. Vol. 3, no. 6. (November 2012.): 411-414.

Bronisz,A; Godlewski,J; Wallace,J,A; Merchant,A,S; Nowicki,M,O; Mathsyaraja,H; Srinivasan,R; Trimboli,A,J; Martin,C,K; Li,F; Yu,L; Fernandez,S,A; Pecot,T; Rosol,T,J; Cory,S; Hallett,M; Park,M; Piper,M,G; Marsh,C,B; Yee,L,D; Jimenez,R,E; Nuovo,G; Lawler,S,E; Chiocca,E,A; Leone,G; Ostrowski,M,C. "Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320." NATURE CELL BIOLOGY. Vol. 14, no. 2. (February 2012.): 159-167.

Yee,Lisa,D; Agarwal,Deepak; Rosol,Thomas,J; Lehman,Amy; Tian,Min; Hatton,Jennifer; Heestand,Jessica; Belury,Martha,A; Clinton,Steven,K. "The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs." MOLECULAR NUTRITION & FOOD RESEARCH. Vol. 57, no. 2. (February 2013.): 320-327.

Lindgren,Monica,E; Fagundes,Christopher,P; Alfano,Catherine,M; Povoski,Stephen,P; Agnese,Doreen,M; Arnold,Mark,W; Farrar,William,B; Yee,Lisa,D; Carson,William,E; Schmidt,Carl,R; Kiecolt-Glaser,Janice,K. "Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients." PSYCHO-ONCOLOGY. Vol. 22, no. 8. (August 2013.): 1889-1894.

Jaremka,Lisa,M; Andridge,Rebecca,R; Fagundes,Christopher,P; Alfano,Catherine,M; Povoski,Stephen,P; Lipari,Adele,M; Agnese,Doreen,M; Arnold,Mark,W; Farrar,William,B; Yee,Lisa,D; Carson,William,E; Bekaii-Saab,Tanios; Martin,Edward,W; Schmidt,Carl,R; Kiecolt-Glaser,Janice,K. "Pain, depression, and fatigue: Loneliness as a longitudinal risk factor.." Health psychology. Vol. 33, no. 9. (September 2014.): 948-957.

Hughes,Spenser; Jaremka,Lisa,M; Alfano,Catherine,M; Glaser,Ronald; Povoski,Stephen,P; Lipari,Adele,M; Agnese,Doreen,M; Farrar,William,B; Yee,Lisa,D; Carson,William,E; Malarkey,William,B; Kiecolt-Glaser,Janice,K. "Social support predicts inflammation, pain, and depressive symptoms: Longitudinal relationships among breast cancer survivors." PSYCHONEUROENDOCRINOLOGY. Vol. 42, (April 2014.): 38-44.



"Cancer Prevention." Presented at Surgical Grand Rounds, Columbus, OH. (December 2002)

"Physical & Psycho-social Issues after Breast Cancer Diagnosis: Hormones, Fertility, Menopause." Presented at Delivering the Promise, 6th Annual Mission Conference of the Susan G. Komen Breast Cancer Foundation, Washington, D.C.. (June 2003)

"Management of High Risk Breast Patients." Presented at Department of Obstetrics and Gynecology Grand Rounds, Columbus, OH. (June 2003)

"PPARs, fatty acids and breast cancer." Presented at Breast Research Round Table, Kansas City, KS. (January 2003)

"Management of Menopausal Symptoms in Women at High Risk and in Breast Cancer Survivors." Presented at Breast Cancer Risk: Emerging Issues and Strategies for Patient Management, Columbus, OH. (February 2004)

"Surgical Management of Breast Cancer." Presented at Hematology-Oncology Fellowship Lecture Series, Columbus, OH. (May 2004)

"PPARgamma, fatty acids, and breast cancer prevention." Presented at Ohio State University Nutrition Seminar, Columbus, OH. (May 2005)

"Breast Cancer Prevention." Presented at Surgical Grand Rounds, Columbus, OH. (May 2008)


Professional Activities

2002 - present Living with Lymphedema: A Comprehensive Care Model. The James Cancer Hospital, Columbus Affiliate of the Susan G. Komen Breast Cancer Foundation. Columbus, OH.
2004 - present Department of Defense Breast Cancer Research Program.
2011 - present World Cancer Research Foundation Grant Program. World Cancer Research Foundation.
1999 - 2003 NCCN Patient/Physician Communication Task Force. National Comprehensive Cancer Network.
2003 Medical Reviewer. Susan G. Komen Breast Cancer Foundation.
2003 - 2004 Advisory Committee. The Ribbon: Advice for Life after Breast Cancer. Columbus, OH.
2000 - 2009 Susan G. Komen Breast Cancer Foundation.