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David R. Brigstock, Ph.D.


The Ohio State University
700 Childrens Dr.
Columbus, Ohio, 43205
Phone: (614) 722-2840

Degrees

January 1984 Brunel University
January 1988 - January 1991 Harvard Medical School
January 1998 PhD, University of Cambridge

Research

Books, Articles, and Other Published Papers

Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M (2009) Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and β cell proliferation during embryogenesis. Mol Endocrinol 23:324-36.

Lawrenica C, Charrier A, Huang G and Brigstock DR (2009) Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells Growth Factors 27 91-99

Wang J, Leclercq, Brymore JM, Ramezani-Mogadam M, London RM, Brigstock DR, George J (2009). Kupffer cells mediate leptin-induced liver fibrosis Gastroenterology 137 713-723

Brigstock DR (2009) Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. J. Cell Comm Signal 3 5-18

Tong Z, Chen R, Kemper S, Perbal B, and Brigstock DR (2009) Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes Hepatology 50 939-947

Gao R and Brigstock DR (2009) Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function. World J Gastroenterology 15 3807-3813

Brigstock DR (2009) Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: Lessons from transgenic animals. J. Cell Comm. Signal http://dx.doi.org/1007/s12079-009-0071-5

Leask A, Chen S, Pala D, and Brigstock DR (2008) Regulation of CCN2 expression and promoter activity in activated hepatic stellate cells. J. Cell Comm. 2 49-56

Tong Z, Brigstock, D.R. (2006) Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor J. Endocrinol 188 R1-R8

Gao, R. and Brigstock, D.R. (2006) A novel integrin ?5?1–binding domain in module 4 of connective tissue growth factor promotes adhesion and migration of activated pancreatic stellate cells. Gut 55 856-862.

Gao R and Brigstock DR (2005) Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin ?5?1 as a novel CCN2 receptor. Gastroenterology 129 2019-2030

Gao R, Ball DK, Perbal B, Brigstock DR (2004) Connective tissue growth factor (CCN2) induces c-fos gene activation and cell proliferation through p44/42 MAP kinase (ERK1/2) in primary rat hepatic stellate cells J. Hepatol 40 431-438

Gao R., Brigstock DR (2004) Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its carboxyl-terminal domain to integrin ?v?3 and heparan sulfate proteoglycans. J Biol Chem 279 8848-8855

Ball, D.K., Moussad, E.E-D.A., Rageh, M.A.E., Kemper, S.A, Brigstock, D.R. (2003) Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction 125 271-284

Wang JF, Olson ME, Ball DK, Brigstock DR, Wright JB, Hart DA (2003). Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression.Wound Repair Regen 11 220-229

Gao R, Brigstock DR (2003) Low-density lipoprotein receptor-related protein is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 27 214-220

Ball DK, Wilson AW, Kemper SA, Brigstock DR (2003). The heparin-binding 10kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol 176 R1-R7

di Mola FF, Friess H, Riesle E, Koliopanos A, Buchler P., Zhu Z, Brigstock DR, Korc M, Buchler MW (2002) Connective tissue growth factor (CTGF) is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Annals Surgery 235 60-67

Williams, E.J., Gaca, M.D.A., Brigstock, D.R., Arthur, M.J.P, and Benyon, R.C. (2000) Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J. Hepatology 32 754-761

Brigstock, D.R., Steffen, C.L. Kim, G.Y., Vegunta, R.K. Diehl, J.R. and Harding P.A. (1997) Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: Identification as heparin-regulated 10,000-Mr forms of connective tissue growth factor. J. Biol. Chem.272 20275-20282

Peer-Reviewed Journal Articles

1. Gao R; Brigstock DR, "Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.". The Journal Of Biological Chemistry. Vol. 279, no. 10: 8848. 2004.

2. Rachfal AW; Luquette MH; Brigstock DR, "Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour.". Journal Of Clinical Pathology. Vol. 57, no. 4: 422. 2004.

3. Rachfal AW; Brigstock DR, "Structural and functional properties of CCN proteins.". Vitamins And Hormones. Vol. 70, 69. 2005.

4. Köninger J; di Mola FF; Di Sebastiano P; Gardini A; Brigstock DR; Innocenti P; Büchler MW; Friess H, "Transforming growth factor-beta pathway is activated in cholecystolithiasis.". Langenbeck's Archives Of Surgery / Deutsche Gesellschaft Für Chirurgie. Vol. 390, no. 1: 21. 2005.

5. Cicha I; Yilmaz A; Klein M; Raithel D; Brigstock DR; Daniel WG; Goppelt-Struebe M; Garlichs CD, "Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro.". Arteriosclerosis, Thrombosis, And Vascular Biology. Vol. 25, no. 5: 1008. 2005.

6. Brigstock D; Lau L; Perbal B, "Report and abstracts of the 3rd International Workshop on the CCN Family of Genes. St Malo, France, 20-23 October 2004.". Journal Of Clinical Pathology. Vol. 58, no. 5: 463. 2005.

7. Gao R; Brigstock DR, "Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor.". Gastroenterology. Vol. 129, no. 3: 1019. 2005.

8. Gao R; Brigstock DR, "Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells.". Cell Communication And Signaling: CCS. Vol. 3, 14. 2005.

9. Tong ZY; Brigstock DR, "Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor.". The Journal Of Endocrinology. Vol. 188, no. 3: R1. 2006.

10. Csencsits K; Wood SC; Lu G; Faust SM; Brigstock D; Eichwald EJ; Orosz CG; Bishop DK, "Transforming growth factor beta-induced connective tissue growth factor and chronic allograft rejection.". American Journal of Transplantation: Official Journal of The American Society of Transplantation and The American Society of Transplant Surgeons. Vol. 6, no. 5 Pt 1: 959. 2006.

11. Gao R; Brigstock DR, "A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells.". Gut. Vol. 55, no. 6: 856. 2006.

12. Cooker LA; Peterson D; Rambow J; Riser ML; Riser RE; Najmabadi F; Brigstock D; Riser BL, "TNF-alpha, but not IFN- gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis.". American Journal Of Physiology. Renal Physiology. Vol. 293, no. 1: F157. 2007.

13. Baran CP; Opalek JM; McMaken S; Newland CA; O'Brien JM Jr; Hunter MG; Bringardner BD; Monick MM; Brigstock DR; Stromberg PC; Hunninghake GW; Marsh CB, "Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.". American Journal Of Respiratory and Critical Care Medicine. Vol. 176, no. 1: 78. 2007.

14. Boag JM; Beesley AH; Firth MJ; Freitas JR; Ford J; Brigstock DR; de Klerk NH; Kees UR, "High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia.". British Journal of Haematology. Vol. 138, no. 6: 740. 2007.

15. Dean RA; Butler GS; Hamma-Kourbali Y; Delbé J; Brigstock DR; Courty J; Overall CM, "Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis.". Molecular And Cellular Biology. Vol. 27, no. 24: 8454. 2007.

16. Leask A, Chen S, Pala D, Brigstock DR., "Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells.". J Cell Commun Signal. Vol. 2, no. 1-2: 49-56. 2008.

17. Liu J; Xu W; Sun T; Wang F; Puscheck E; Brigstock D; Wang QT; Davis R; Rappolee DA, "Hyperosmolar stress induces global mRNA responses in placental trophoblast stem cells that emulate early post-implantation differentiation.". Placenta. Vol. 30, no. 1: 66. 2009.

18. Crawford LA; Guney MA; Oh YA; Deyoung RA; Valenzuela DM; Murphy AJ; Yancopoulos GD; Lyons KM; Brigstock DR; Economides A; Gannon M, "Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.". Molecular Endocrinology (Baltimore, Md.). Vol. 23, no. 3: 324. 2009.

19. Brigstock DR, "Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.". Journal of Cell Communication and Signaling. Vol. 3, no. 1: 5. 2009.

20. Lawrencia C; Charrier A; Huang G; Brigstock DR, "Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.". Growth Factors (Chur, Switzerland). Vol. 27, no. 2: 91. 2009.

21. Zhou Y; Brigstock D; Besner GE, "Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles.". Microvascular Research. Vol. 78, no. 1: 78. 2009.

22. Wang J; Leclercq I; Brymora JM; Xu N; Ramezani-Moghadam M; London RM; Brigstock D; George J, "Kupffer cells mediate leptin-induced liver fibrosis.". Gastroenterology. Vol. 137, no. 2: 713. 2009.

23. Gao RP; Brigstock DR, "Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.". World Journal of Gastroenterology: WJG. Vol. 15, no. 30: 3807. 2009.

24. Tong Z; Chen R; Alt DS; Kemper S; Perbal B; Brigstock DR, "Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes.". Hepatology (Baltimore, Md.). Vol. 50, no. 3: 939. 2009.

25. Brigstock DR, "Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals.". Journal Of Cell Communication And Signaling. Vol. 4, no. 1: 1. 2010.

26. Charrier AL; Brigstock DR, "Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.". Laboratory Investigation; A Journal Of Technical Methods And Pathology. Vol. 90, no. 8: 1179. 2010.

Prizes and Awards

1986, New Investigator Award,

1996, Finalist, Society for the Study of Fertility,

2000, Invited Speaker, Gordon Conference on Reproductive Tract Biology,

2002, Invited Speaker & Session Chairman, International Symposia on CCN Gene Family (1st 2000, 2nd 2002, 3rd 2004, 4th 2006),

2002, Fellow, Society of Biology,