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Research

Chandan K. Sen, Ph.D.


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 257-7786

Email: sen.16@osu.edu

 

Current OSU Appointments

Professor, General Surgery

Professor, SBS-Biolog Chem & Pharmacology

Associate Dean, ADM-Medicine Administration

Adjunct Professor, College of Nursing

 

Biographical

OTHER EXPERTISE
Editorial Board, Physiological Genomics

Advising Narrative

Biological Sciences
Biological Sciences
BS with Distinction in Biology

Books

SKELETAL MUSCLE RESEARCH: CELLULAR PHYSIOLOGY & BIOCHEMISTRY

EXERCISE AND OXYGEN TOXICITY

SKELETAL MUSCLE RESEARCH: METABOLISM & PATHOPHYSIOLOGY

OXIDATIVE STRESS IN SKELETAL MUSCLES

ANTIOXIDANT AND REDOX REGULATION OF GENE

HANDBOOK OF OXIDANTS & ANTIOXIDANTS IN EXERCISE

METHODS IN ENZYMOLOGY: Redox Cell Biology & Genetics. Part B

METHODS IN ENZYMOLOGY: Redox Cell Biology & Genetics. Part A

Methods in Enzymology: Oxygen Sensing

 

Chapters in Books

Foreword

A Novel Model for the Study of Angiogenesis

Glutathione Defense in Neutrophil Induced Post Exercise Muscle Damage

Oxygen Free Radicals in Physical Exercise

Antioxidant Supplementation and the Control of Oxygen Toxicity During Exercise

Physiological Antioxidants

Detoxification of Reactive Oxygen Species: Molecular Strategies

Exercise-induced oxidative stress and antioxidant defenses [in Finnish language: Liikunta synnyttää happiradikaaleja - antioksidatiivinen.puolustusketju.]

Oxidative Stress Induced by Physical Exercise

Exercise Induced Oxidative Stress in Diabetes Mellitus

Exercise induced oxidative stress in diabetes mellitus

Therapeutic Potential of Alpha-Lipoic Acid: Molecular Aspects

Glutathione dependent antioxidant protection in skeletal muscle: Exercise and Training

Therapeutic Potential of the Antioxidant and Redox Properties of Alpha-Lipoic Acid

Oxidants and antioxidants in glutamate-induced cytotoxicity

Glutathione: A Key Role in Skeletal Muscle Metabolism

Strategies to Assess Oxidative Stress

Ginkgo biloba extract (EGb 761): antioxidant properties and regulation of gene expression

Redox Regulation of Cellular Responses by Alpha-Lipoic Acid

Alpha-Lipoic Acid: Cell Regulatory Function and Potential Implications

Down-Regulation of Agonist-Induced Nitric Oxide Synthesis and Cell-Cell Adhesion by Ginkgo Biloba Extract EGb761: Therapeutic Efficacy in Circulatory Disorders

Oxidants and Antioxidants in Apoptosis: Role of bcl-2

Determination of Nuclear Factor Beta Activity

Exercise induced oxidative stress and antioxidant nutrients

Exercise and Oxidative Stress in Diabetes Mellitus

Biological Thiols and Redox Regulation of Cell Signaling

Antioxidants and Physical Exercise

Physiological Antioxidants and Exercise Training

Redox Regulation of Mitochondrial Permeability Transition: Contrasting effects of Lipoic Acid and Its Positively Charged Analoge LA-plus

Wound Healing and Regeneration, in Physiology and Maintenance

Alpha-Lipoic Acid

Redox Regulation of Angiogenesis Anti-Angiogenic Properties of Edible Berries and Its Significance in a Clinical Setting

Obesity and Angiogenesis

Role of Edible Berry Anthocyanins in Angiogenesis

Angiogenesis Targeted Redox-Based Therapeutics

Revascularization of wounds: The oxygen-hypoxia paradox

 

Conferences

Regulation of 3,3',4,4'-tetrachlorobiphenyl induced cytochrome P450 metabolism by thiols in tissues of rainbow trout

Physical exercise and antioxidant defenses in the heart

Update on thiol status and supplements in physical exercise

Cellular protection with proanthocyanidins derived from grape seeds

Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract

 

Degrees

1990 M.S., Calcutta University

1994 Ph.D., University of Kuopio

 

Edited Books

Skeletal Muscle Research: Cellular Physiology & Biochemistry

Skeletal Muscle Research: Metabolism & Pathophysiology

Exercise and Oxygen Toxicity

Oxidative Stress in Skeletal Muscles

Antioxidant and Redox Regulation of Genes

Handbook of Oxidants & Antioxidants in Exercise

Methods in Enzymology: Redox Cell Biology & Genetics Part A

Methods in Enzymology: Redox Cell Biology & Genetics Part B

Methods in Enzymology: Oxygen Sensing

 

Editorial Activities

1999 - 2007 Journal of Applied Physiology
1999 - 2007 Antioxidants & Redox Signaling
2002 - 2005 Current Topics in Nutraceutical Research
2002 - 2007 Medicine & Science in Sports and Exercise
2002 - 2007 DNA & Cell Biology
2003 - present Dynamic Medicine
2003 - 2006 Physiological Genomics
2005 - 2007 Genes & Nutrition
2006 - 2007 Physiological Genomics
2007 Redox Report
2007 Science
2007 Pharmacological Research
2007 Free Radical Research
2007 Free Radical Biology & Medicine
2007 FASEB Journal
2007 Journal of Applied Physiology
2007 Arch. Biochemistry & Biophysics
2007 Molecular & Cell Biochemistry
2007 Medicine & Science in Sports and Exercise
2007 Life Science
2007 Experimental Gerontology
2007 Diabetologia
2007 American Journal of Physiology
2007 American Journal of Clinical Nutrition
2007 Acta Physiologica Scandinavica
2007 Stroke
2007 Journal of Physiology (London)
2007 Journal of Immunology
2007 Journal of Nutrition
2007 Circulation
2007 Cancer Research
2007 Physiological Genomics
2007 Journal of Molecular & Cellular Cardiology
2007 Journal of Clinical Investigation
2007 Biochimica Biophysica Acta
2007 Arteriosclerosis, Thrombosis, and Vascular Biology
2007 European Journal of Applied Physiology
 

Honors

1989 - present Prof. S.R. Moitra Memorial Gold Medal.
1994 - present Order of the Horse Collar Knights.
1997 - present Fellow.
1997 - present Jogue Young Scientist Award.
1998 - present President's Honor Award. International Society of Pathophysiology.
1998 - present Young Investigator Award. International Society of Free Radical Research.
2001 - present Fellow. American College of Nutrition.
2002 - present Outstanding Contribution to Education Award.
2002 - present Citation of Recognition. Mayor of Columbus, Columbus, OH.
2003 - present Honorary Member. Alpha Epsilon Delta National Honors Society.
2004 - present Bowditch Award Nominee.
2005 - present Star Award - Physiological Society.
2005 - present Honorary Member.
2005 - present Creativity Award (group).
2006 - present Session Moderator, 16th Annual Meeting.
2008 Columbus TopCAT award finalist.
 

Journal Articles

"DNA microarray technology in nutraceutical and food safety." Toxicology Letters. Vol. 150, no. 1. (April 2004.): -.

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"Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing." FREE RADICAL BIOLOGY AND MEDICINE. Vol. 44, no. 4. (February 2008.): -.

 

Inventions and Patents

Lipoic Acid Analogs

Methods and compositions for wound healing

 

Presentations

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Hyperbaric Therapy Current Concepts and Practice Training Program

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Redox Signaling and Cellular Function

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Novel Insights from Vitamin E Neuroprotection

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Tocotrienol: Potent Neuroprotection By a Non-Tocopherol Natural Vitamin E

KL4: Tocotrienols: Kindling the Hope Against Neurodegeneration and Stroke

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Therapeutic Management of Inflammation

Redox: The Signal to Heal?

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Perceived Hyperoxia: Oxygen Sensitive Myocardial Remodeling

Tissue Remodeling

Spotlight on Neuroprotection by Natural Vitamin E Alpha-Tocotrienol

Setting Up the Translation Wound Research Infrastructure

New Horizons in Vitamin E Neuroprotection

Neuroportection By A Non-Tocopherol Form of Natural Vitamin E

The case for alpha-tocotrienol against stroke

Switch of Myocardial Fibroblasts

Tocotrienol: the natural vitamin E against stroke-related neurodegeneration

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Vitamin E and Brain Health: Looking Beyond Tocopherols

Advanced Collaborative Medical Redox Navigation Research COE

How does a reviewer perceive/evaluate the proposal?

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Redox: The Signal to Heal?

Palm Tocotrienol Complex's Function in Preventing Brian Disease

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Oxygen and the Postischemic Heart: An Untold Story of Tissue Remodeling

Neuroprotective Properties of the Natural Vitamin E Alpha-Tocotrienol

Surgical Infections & Healing Surgical Wounds

Vitamin E in Stroke: A New Angle?

Laser Microdissection Pressure Catapulting

Dead Cell Clearance in Wound Inflammation

Emerging Trends in Free Radical and Antioxidant Research

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Remodeling of the Post-Ischemic Heart: Oxygen-Sensitive Phenotypic Switch of Primary Adult Cardia Fibroblasts

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Professional Activities

1998 - present tenure of assistant professor.
1999 - present NCI P01 grant.
1999 - present Immunology Study Section. NIH.
1999 - present National Science Foundation.
2000 - present Veteran Affairs Medical.
2000 - present promotion of associate professor.
2000 - present Book proposals. Commercial Publishing Houses.
2000 - present The Office of Naval Research.
2000 - present American Institute of Biological Sciences.
2001 - present Respiratory & Applied Physiology.
2001 - present Cardiovascular Sciences.
2003 - present EB03 SSS M58.
2003 - present tenure of assistant professor.
2004 - present ZRG1 SSS M(52)(R).
2004 - present ZRG1 SSS M(01)(Q).
2004 - present Southern/Ohio Valley 5B.
2005 - present Member of External Advisory Board for the University of Texas Medical Branch Wound Healing Redox Regulation Research Team. Galveston, TX.
2005 - present tenure of senior lecturer.
2005 - present NHLBI PO1 Review.
2006 - present NIH Study Section, Special Emphasis Panel/Scientific Review Group ZRG1 SBIB-E (02) M.
2006 - present NIH Study Section. SAT.
2007 - present NIH Study Section, Special Emphasis Panel/Scientific Review Group.
2007 - present NIH Study Section, VCMB.
2001 the 6th Annual Congress of the European College of Sport Science (ECSS) Meeting. American College of Sports Medicine (www.acsm.org).
2000 - 2003 National Space and Biomedical Research Insititute/ NASA.
2005 - 2006 Program Project Application of Dr. Mark Entman.