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Research

Gail E. Besner, M.D.


700 Childrens Dr
Columbus, OH 43205

Phone: (614) 722-3900

Email: besner.2@osu.edu

 

Current OSU Appointments

Professor, Pediatric Surgery

Professor, Pediatrics

 

Academic Advising

present Rajan Thakkar,, Nationwide Children's Hospital.
present Matthew Todd, OSU.
present Robert Gates,, Nationwide Children's Hospital.
present Christina Hinman,, Nationwide Children's Hospital.
present Jeffrey Halter,, Nationwide Children's Hospital.
present Laura Boomer,, Nationwide Children's Hospital.
present Dorothy Rocourt,, Nationwide Children's Hospital.
present Marc Michalsky,, The Ohio State University.
present Jixin Yang,, Nationwide Children's Hospital.
present Iyore Otabor,, The Ohio State University.
present Jia Wei,, Nationwide Children's Hospital.
present Claudio Lagoa,, Nationwide Children's Hospital.
present Jiexiong Feng,, Nationwide Children's Hospital.
present Hong-Yi Zhang, Nationwide Children's Hospital.
present Rahul Basho, OSU.
present Chad Hamner,, Nationwide Children's Hospital.
present Azim Haque, Case Western Reserve University.
present Dan Teitelbaum,, University of Michigan.
present Joanna Askegard-Geismann,, Nationwide Children's Hospital.
present Michelle Mackey, OSU.
present Heather Paddock,, Nationwide Children's Hospital.
present Yu Zhou,, Nationwide Children's Hospital.
present Meghan Ryan, OSU.
present David Scarda,, Nationwide Children's Hospital.
present Katherine Dominguez,, Nationwide Children's Hospital.
present David Yu,, The Ohio State University.
present Avanti Jakadtar, OSU.
present Keith Webb,, Nationwide Children's Hospital.
present Diane W., Nationwide Children's Hospital.
present Anthony Georges,, Nationwide Children's Hospital.
present Andrei Radulescu,, Riverside Methodist Hospital.
present Sanjay Krishnaswami,, University of Oregon.
present Ann Kuhn,, Nationwide Children's Hospital.
present Thomas Sims,, Nationwide Children's Hospital.
present Yanwei Su,, Nationwide Children's Hospital.
present Maria Lara-Marquez,, Nationwide Children's Hospital.
present Bharath Bhushan, OSU.
present Mark Downing,, Nationwide Children's Hospital.
present Guliang Xia,, Nationwide Children's Hospital.
present Terry Rager,, OSU.
present Diane McCarthy,, Nationwide Children's Hospital.
present Colin Bethel,, Nationwide Children's Hospital.
present Chun-Liang Chen,, Nationwide Children's Hospital.
present Angela Hanna,, Nationwide Children's Hospital.
present Randolph Cribbs,, Nationwide Children's Hospital.
present Nashith Bhattacharyya,, Nationwide Children's Hospital.
present Khaled Mutabagani,, Nationwide Children's Hospital.
present John Gosche,, Nationwide Children's Hospital.
present Ravindra Vegunta,, Nationwide Children's Hospital.
present Jennifer Aldrink,, Nationwide Children's Hospital.
present Karen Davis,, Nationwide Children's Hospital.
present Ann O'Connor,, Nationwide Children's Hospital.
present Denis Bensard,, University of Colorado.
present Lindsay Grier, Nationwide Children's Hospital.
present Jonathan Groner,, The Ohio State University.
present Nathan Orvets, OSU.
present Alice Ji, OSU.
present Kyle Markmann, OSU.
present April Edwards, The Ohio State University.
present Linda Chun, OSU.
present Sarah Brehm, OSU.
present Abigail Martin,, Duke University.
present Jacob Olson, OSU.
present Shahab Abdessalam,, University of Nebraska.
present Dan Watkins,, Nationwide Children's Hospital.
present Paul Harding,, Nationwide Children's Hospital.
present Helena Crowley,, St. Christopher's Hospital for Children.
present Sri Pallai,, Cook County Hospital.
present Cynthia Corpron,, Syracuse University.
present Mehul Raval,, Nationwide Children's Hospital.
2010 - present Kevin Peine, Nationwide Children's Hospital.
 

Licenses

1983 - present Certificattion: National Board of Medical Examiners
1988 - present Certification: American Board of Surgery
1991 - present Ohio Medical License: State Medical Board of Ohio
1993 - present Instructor: American Burn Association
1993 - present Provider: American Burn Association
1998 - present Diplomat-General Surgery: American Board of Surgery
2003 - present Provider: American Heart Association
1987 - 1989 Massachusetts Medical License: Commonwealth of Massachusetts Board of Registration in Medicine
1989 - 1991 New York Medical License: New York Medical Board
1992 - 2012 Certification: American Board of Surgery
1992 - 2013 Certification: American Board of Surgery
 

Chapters in Books

Penetrating neck trauma in children: a reappraisal.

Pediatric electrical burns: management strategies.

Testicular Problems and Varicoceles

Burns

Breast Disorders

 

Clinical Services

01/01/1977 - 01/01/1978 Research Fellowship (Cornell University)
01/01/1982 - 01/01/1983 Intern (Brigham & Women's Hospital)
01/01/1983 - 01/01/1987 Resident (Brigham & Women's Hospital)
01/01/1987 - 01/01/1989 Research Fellow (Children's Hospital Boston Massachusetts)
01/01/1989 - 01/01/1990 Senior Resident (The Children's Hospital of Buffalo)
01/01/1990 - 01/01/1991 Chief Resident (The Children's Hospital of Buaffalo)
01/01/1991 - 01/01/2013 CLINICAL ATTENDING (NATIONWIDE CHILDREN'S HOSPITAL, COLUMBUS)
01/01/1991 - 01/01/2013 CONSULTANT IN PEDIATRIC SURGERY (MOUNT CARMEL MEDICAL CENTER, COLUMBUS)

Conferences

Nonteratomatous germ cell tumors in children

Fall injuries in the pediatric population: Safer and most cost-effective management

 

Degrees

1978 B.A., Cornell University

1982 M.D., University of Cincinnati College of Medicine

 

Editorial Activities

present Pediatric Research
present Journal of Burn Care and Rehabilitation
present E Medicine, Textbook of Pediatric Surgery
present Cell Proliferation
present American Journal of Physiology
present American Journal of Perinatology
present American Journal of Obstetrics and Gynecology
present American Journal of Pathology
present Surgery
present Seminars in Pediatric Surgery
present Journal of the American College of Surgeons
present Journal of Pediatric Surgery
present Journal of Investigative Surgery
present Pediatrics
present Nitric Oxide: Biology and Chemistry
 

Honors

1974 New York State Regents Scholarship. Bronx High School of Science.
1974 - 1978 Dean's List.
1978 Magna Cum Laude with distinction in all subjects.
1982 Citation for Scholastic Achievement. American Medical Women's Association.
1982 Alpha Omega Alpha Honor Medical Society.
1987 - present Pediatric Surgery Research Project.
1990 Grand Prize Winner, ACS Western New York Chapter Essay Contest.
1992 - present Research Award.
1992 Research Award - Special Commendation for Excellence in Research.
1993 Research Award - Special Commendation for Excellence in Research.
1994 Research Award - Third Prize Winner - Resident's Paper Competition. Presidential Symposium.
1996 Research Award - Second Prize Winner - Resident's Paper Competition. Presidential Symposium.
1997 Sterling Who's Who.
1997 Research Award - Second prize Winner - Resident's Paper Competition. Annual Surgery Residetn's Forum, Huntington, West Virginia.
1997 Research Award - Second Prize Winner - Graduate Student Research Competition.
1997 Research Award - First Prize Winner - Resident's Paper Competition. Presidential Symposium.
1997 Research Award - First Prize Winner - Graduate Student Research Competition.
1998 - present Research Award.
1998 Strathmore's Who's Who.
1999 - present Research Award - First Prize Winner Resident Paper Competition.
1999 Research Award - Second Prize Winner - Resident's paper Competition.
1999 Research Award - First Prize Winner – Resident’s Paper Competition. Fourth Annual Resident’s Research Conference.
1999 Marquis' Who's Who in Medicine and Health Care.
2000 - present Research AwardFirst - Prize Winner Residents Paper Competition.
2000 Research AwardFirst - Prize Winner – Resident’s Paper Competition. Presidential Symposium.
2000 Research Award - Third Prize Winner - Graduate Student Research Competition.
2000 Research Award - First Prize Winner - Graduate Student Research.
2000 Recognition Award for Surgical Separation of Conjoined Twins from Africa. Liberian Friendship Association.
2001 The Grant Morrow III Resident Fellow Research Award - First Place Winner.
2001 Best Surgical Presentation Award, Advances in Pediatric Surgery.
2001 Best Program Award, Advances in Pediatric Surgery.
2002 The Communicator Award of Distinction.
2004 Research Award - First Place Winner Best Research Fellow.
2006 - present Nationwide Children's Hospital Art in Science Competition - Honorable Mention.
2006 Nationwide Children’s Hospital Art in Science Competition - Honorable Mention.
2006 Research Award- First Prize Winner-Resident Research Competition.
2007 - present The Global Directory of Who's Who.
2007 - present America's Best Doctors. U.S. News & World Report.
2007 The Global Directory of Who’s Who.
2007 Winner in Outstanding Woman in Technology Category. Tech Ohio Top Contributors to the Advancement of Technology (TopCAT) Award.
2007 Health Care Heroes Award.
2007 - 2008 Best Doctors in America.
2008 - present Who's Who.
2008 - present Research Award - Bronze Medal Winner Resident Paper Competition.
2008 Research Award - Post-doctoral Fellow Research Award.
2008 Research Award - Bronze Medal Winner – Resident’s Paper Competition. Presidential Symposium.
2008 Outstanding House Staff Publication Award.
2008 Who’s Who “Honors Edition”.
2008 Endowed Chair, John E. Fisher Professor of Neonatal Research.
2009 - present Strathmore's Who's Who.
2009 - present Research Award - Gold Medal Winner Resident Paper Competition.
2009 Strathmore’s Who’s Who.
2009 Hero Recognition Award, Columbus Church of Christ.
2009 Research Award - Prize Winner.
2009 Research Award - Medical Student Research Award.
2009 Research Award - Gold Medal Winner – Resident’s Paper Competition. Presidential Symposium.
2009 Best Doctors in America.
2010 - present Winner Trainee Travel Award Competition.
2010 - present Second Place Prize Clinical Category.
2010 - present Post-Doctoral Fellow Research Award.
2010 Research Award - Post-doctoral Fellow Research Award.
2010 Research Award - Gold Medal Winner – Resident’s Paper Competition. Presidential Symposium.
2010 Winner – Trainee Travel Award Competition. Annual International Symposium on Cells of the Hepatic Sinusoid.
2010 Second Place Prize – Clinical Category.
2011 - present Research Award, 16th Annual Dept. of Surgery.
2011 - present James D. King Research Award.
2012 - present Denis R. King Teacher of the Year Award.
2012 - present Columbus Surgical Society.
 

Journal Articles

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Softwares

July 2009 ."Heparin-binding EGF-like growth factor increases intestinal microvascular blood flow in necrotizing enterocolitis."

Inventions and Patents

Heparin-binding Mitogen with Homology to EGF

Heparin-binding Mitogen with Homology to EGF

Heparin-binding Mitogen with Homology to EGF

Heparin-binding Mitogen with Homology to EGF

Method of Treating Intestinal Ischemia Using Heparin-Binding Epidermal Growth Factor

Methods of Treating Necrotizing Enterocolitis using Heparin Binding Epidermal Growth Factor

Method of Treating Shock Using Heparin-Binding EGF-Like Growth Factor

 

Presentations

Characterization and Prufication of a Heparin-Binding Growth Factor from Mononuclear Cell Conditioned Medium.

A Novel Macrophage-Secreted Growth FActor and It's Possible Role in the Regulation of Angiogenesis

Familial Hirschprung's Disease

Macrophages Secrete a Novel Endothelial Cell Inhibitor: Possible Roles in Angiogenesis

Surfactant Replacemetn for the HIgh Risk Neonate with CDH

Heparin-dependence of the interaction of heparin-binding EGF-like growth factor (HB-EGF) with the EGF receptor

Heparin-binding epidermal growth factor (HB-EGF): A novel growth factor with potential intestinal cytoprotective effects

A new aspect in the wound healing module - heparin-binding epidermal growth factor (HB-EGF). What role does heparin binding play?

Specific protein expression by a metastasizing clone of murine neuroblastoma

Novel forms of epidermal growth factor in uterine fluids

Hyper-responsiveness of atherogenic vascular smooth muscle cells to members of the EGF family

Characterization of a polypeptide growth factor in human urine

Specific protein expression by a metastasizing clone of murine neuroblastoma

Epidermal growth factor in uterine fluids

Human burn wound fluid contains heparin-binding EGF-like growth factor (HB-EGF) and platelet-derived growth factor (PDGF)

Heparin-binding epidermal growth factor (HB-EGF) - New implications in wound healing

Production and characterization of recombinant human HB-EGF in E. coli

Human burn wound fluid contains HB-EGF-like factors and PDGF-like factors

Urinary heparin-binding growth factor (uHBGF)

Immunohistochemical localization of heparin-binding EGF-like growth factor in diseased skin

Immunohistochemical localization of heparin-binding EGF-like growth factor in diseased skin

An analysis of O-glycosylation in human heparin-binding EGF-like growth factor

Definitive percutaneous treatment of lymphatic malformations of the trunk and extremities

HB-EGF promotes P38MAPK-dependent endothelial cell migration and angiogenesis without stimulating proliferation

HB-EGF knockout mice have increased intestinal permeability after intestinal ischemia/reperfusion injury

HB-EGF knockout mice have delayed angiogenesis after intestinal ischemia/reperfusion injury

HB-EGF increases intestinal microvascular blood flow in rats subjected to ischemia/reperfusion injury

HB-EGF attenuates experimental liver fibrosis and reduces hepatic stellate cell activation

HB-EGF gene knockout exacerbates liver fibrosis in mice.

 

Professional Activities

0 Ad Hoc Reviewer. Surgery.
0 Ad Hoc Review. American Journal of Physiology.
0 Ad Hoc Reviewer. American Journal of Obstetrics and Gynecology.
0 Ad Hoc Reviewer. Journal of the American College of Surgeons.
0 Ad Hoc Reviewer. Pediatrics.
0 Ad Hoc Reviewer. Journal of Pediatric Surgery.
0 Ad Hoc Reviewer. Pediatric Research.
0 Ad Hoc Reviewer. Journal of the Americna College of Surgeons.
0 Ad Hoc Reviewer. American Journal of Physiology.
0 Ad Hoc Review. Journal of Investigative Surgery.
0 Ad Hoc Reviewer. Journal of Pathology.
0 Ad Hoc Reviewer. Journal of Burn Care and Rehabilitaion.
0 Ad Hoc Reviewer. Nitric Oxide: Biology and Chemistry.
0 Ad Hoc Reviewer. Cell Proliferation.
0 Ad Hoc Reviewer. American Journal of Perinatology.
0 Managing Editor. E Medicine, Textbook of Pediatric Surgery.
0 Guest Editor. Seminars in Pediatric Surgery.