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Research

Pei-Hui Lin, Ph.D.


460 W. 12th Avenue
Columbus, OH 43210

Phone: (614) 292-2802

Email: lin.1658@osu.edu

 

Current OSU Appointment

Research Assistant Professor, Cardiac Surgery

 

Research Interest

disease mechanism in skeletal musce, heart and kidney; protein therapeutics and tissue repair, regeneration

Professional Interests Narrative

I'm interested in the signaling pathways in the physiological processes, such as tissue repair and regeneration, and the underlying disease mechanism.
I have strong passion toward the continued learning and education of our future generations.

Academic Advising

2013 - present , The Ohio State University.
2015 - present , The Ohio State University.
 

Conferences

N/A

Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair

Non-muscle Myosin IIA Facilitates Vesicle Trafficking for MG53-mediated Cell Membrane Repair

MG53 Protein Modulates Therapeutic Cell Membrane Repair in Skeletal Muscle

PTRF anchors MG53 to cell injury site for initiation of membrane repair

Additive phenotype of MG53 and dysferlin deficientcies in membrane repair function of skeletal muscle fibers

TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells

Co-Expression of TRIC-A and Cardiac Ryanodine Receptor affects Store-Overload Induced Calcium Release in HEK293 Cells

The Two-pore channel 2 (TPC2) mediates autophagy in skeletal muscles

Nonmuscle Myosin Heavy Chain Type IIA Is required for TRIM72-mediated proximal tubular cell protection in acute kidney injury

TRIM72 Binds to phosphatidylserine in pre-apoptotic PTE Cells prevents Kim-1 mediated phagocytosis

Superresolution Microscopy Reveals Nanometer-Scale Reorganization of MG53 Associated with Membrane Repair

The therapeutic role of recombinant human MG53 protein in wound healing. Biophysical society

Superresolution Microscope Image Reconstruction by Spatiotemporal Object Decomposition and Association: Application in Resolving T-Tubule Structure in Skeletal Muscle

TRIM 50 interacts with microtubules to facilitate vesicle trafficking in gastric parietal cells

Suppressed Autophagy Flux in Skeletal Muscle of an Amyotrophic Lateral Sclerosis Mouse Model

Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein

MG56, a Member of the MBOAT Family of Proteins, Regulates Intracellular Calcium Signaling in Striated Muscle

MG53 promotes wound healing and reduces scar formation by facilitating cell membrane repair and controlling myofibroblast differentiation

Zinc Binding to MG53 Facilitates Repair of Injury to Cell Membrane

MG53 promotes wound healing and reduces scar formation by facilitating cell membrane repair and controlling myofibroblast differentiation

 

Editorial Activities

2013 - present medical journal
2013 Current Vascular Pharmacology
2013 International Journal of Physical Medicine and Rehabilitation
2014 Journal of Visualized Experiments
2015 Austin Journal of Molecular and Cell Biology
 

Journal Articles

"Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function.." Mechanisms of development. Vol. 94, no. 1-2. (June 2000.): -.

"The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis.." The Journal of biological chemistry. Vol. 281, no. 24. (June 2006.): -.

"Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes.." Biophysical journal. Vol. 90, no. 12. (June 2006.): -.

"The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis.." Journal of cell science. Vol. 120, no. Pt 16. (August 2007.): -.

"Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells.." Journal of cellular physiology. Vol. 216, no. 1. (July 2008.): -.

"The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells.." American journal of physiology. Cell physiology. Vol. 296, no. 2. (February 2009.): -.

"MG53 nucleates assembly of cell membrane repair machinery.." Nature cell biology. Vol. 11, no. 1. (January 2009.): -.

"Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.." The Journal of biological chemistry. Vol. 285, no. 48. (November 2010.): -.

"Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.." Circulation research. Vol. 107, no. 1. (July 2010.): -.

"Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway." EMBO REPORTS. Vol. 12, no. 5. (May 2011.): -.

"Dysferlin, Annexin A1, and Mitsugumin 53 Are Upregulated in Muscular Dystrophy and Localize to Longitudinal Tubules of the T-System With Stretch." JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 70, no. 4. (April 2011.): -.

 

Inventions and Patents

COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES

COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES, KIDNEY AND BONE DYSFUNCTION

 

Professional Activities

present graduate student admission process. OSU. Columbus, OH.
2015 - present as admission screener. osu medical center.
2011 Xinyu Zhou - Graduate Student. Dr. Jianjie Ma’ Lab.
2013 Matt Sermersheim - Graduate Student. Dr. Jianjie Ma’ Lab.
2013 Kristyn Gumpper - Graduate Student. Dr. Jianjie Ma’ Lab.
2001 - 2002 Dr. Erin O’Neill - Postdoctoral Fellows. Dr. Jianjie Ma’ Lab.
2001 - 2003 Dr. Claude Collet - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2001 - 2004 Dr. Xu Wang - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2004 - 2005 Dr. Henrietta Szapponos - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2001 - 2006 Dr. Yutaka Hirata - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2004 - 2006 Dr. Noah Weisleder - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2002 - 2007 Na Li - Graduate Student. Dr. Jianjie Ma’ Lab.
2002 - 2007 Lin Zheng - Graduate Student. Dr. Jianjie Ma’ Lab.
2003 - 2007 Jae-Kyun Ko - Graduate Student. Dr. Jianjie Ma’ Lab.
2003 - 2007 Xiaoli Zhao - Graduate Student. Dr. Jianjie Ma’ Lab.
2007 Christopher Ferrante - Graduate Student. Dr. Jianjie Ma’ Lab.
2003 - 2008 Angela Thornton - Graduate Student. Dr. Jianjie Ma’ Lab.
2004 - 2008 Dr. Chuanxi Cai - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2008 Choon Kee Min - Graduate Student. Dr. Jianjie Ma’ Lab.
2008 Srilatha Simhadri - Graduate Student. Dr. Jianjie Ma’ Lab.
2007 - 2009 Dr. Xiaoli Zhao - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2005 - 2010 Moon-Sun Hwang - Graduate Student. Dr. Jianjie Ma’ Lab.
2007 - 2010 Kyoung-Han Choi - Graduate Student. Dr. Jianjie Ma’ Lab.
2008 - 2010 Dr. Hua Zhu - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.
2007 - 2011 Andoria Tjondrokoesoemo - Graduate Student. Dr. Jianjie Ma’ Lab.
2008 - 2012 Matt Orange - Graduate Student. Dr. Jianjie Ma’ Lab.
2009 - 2014 Dr. GeJing De - Postdoctoral Fellow. Dr. Jianjie Ma’ Lab.