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Research

Raphael E. Pollock, M.D., Ph.D.


410 W 10th Ave
Columbus, OH 43210

Email: pollock.316@osu.edu

 

Current OSU Appointments

Professor, Surgical Oncology

Physician, FGP-Surgical Oncology

 

Academic Advising

2014 - present Lee Ellis,, American Cancer Society. Sponsor for American Cancer Society Clinical Oncology Career Development Award – funded.
2014 - present Peter Pisters,, American Cancer Society. Sponsor for American Cancer Society Clinical Oncology Career Development Award – funded.
2014 - present Barry Feig,, American Cancer Society. Sponsor for American Cancer Society Clinical Oncology Career Development Award – funded.
 

Books

Surgical Oncology

Liver Cancer; M. D. Anderson Solid Tumor Oncology Series

UICC Manual of Clinical Oncology, 7th ed.

Breast cancer; M. D. Anderson Solid Tumor Oncology Series

Cancer Medicine, 5th ed.

Soft Tissue Sarcoma

Pancreatic Cancer, M.D. Anderson Solid Tumor Oncology Series

Soft Tissue Sarcomas; Surgical Oncology Clinics of North America

Cancer medicine

UICC manual of clinical oncology

Principles of Surgery, 8th ed.

Cancer medicine 7th ed.

Advanced Therapy in Surgical Oncology

Principles of Surgery, 9th ed.

Cancer Medicine, 8th ed

 

Chapters in Books

Primary retroperitoneal tumors.

Retroperitoneal tumours.

Soft tissue sarcomas.

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ONCOLOGY

Surgical procedures for advanced local and regional malignancy of the breast

Small bowel tumors

Formulating an initial research plan

Writing grant applications for laboratory research

Resection of soft tissue sarcomas

Splenectomy in the patient with cancer

Soft-tissue sarcoma of the extremities. MR appearance of post-treatment changes and local recurrences.

SURGICAL-MANAGEMENT OF PRIMARY SOFT-TISSUE SARCOMA

Molecular determinants of sarcoma metastasis

Soft tissue tumours.

Surgical procedures for advanced local and regional malignancies of the breast

Applying for funding from the NIH: a useful paradigm for most applications

Formulating an original research plan

Multicenter collaborative clinical trials

Breast sarcoma

New surgical approaches to soft tissue sarcoma

High risk soft tissue sarcoma: an overview

Soft tissue sarcoma

History of the M. D. Anderson surgical training program

Sarcomas of Soft Tissue and Bone

Principles of surgical oncology

Radical amputation

Abdominal wall sarcoma

Soft tissue sarcoma

Prognostic factors in soft tissue sarcoma

Principles of Surgical Oncology

Epidemiology, pathology, molecular biology, and natural history of gastrointestinal sarcomas

Soft tissue sarcomas

Principles of surgical cancer care

Principles of Surgical Oncology

Soft tissue sarcoma.

Surgical oncology in multimodality cancer care: History and Scope

Unintended effects of cancer surgery

Soft-tissue Sarcoma

Long-Term Consequences of Cancer Surgery

Surgical procedures for advanced local and regional malignancies of the breast

Soft Tissue Sarcoma

Principles of Surgical Oncology

Soft tissue sarcoma

Gene Therapy for Sarcoma

Alveolar soft-part sarcoma of the orbit.

Fore-Quarter Amputation

Clinical dilemmas paradoxes: unique patterns of metastasis by common and rare types of cancer

Surgical management of desmoid tumors

Role of Translation and its Regulation in Sarcoma

 

Conferences

Lower extremity salvage in cancer patients using free tissue transfer

 

Journal Articles

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Presentations

Surgical stress mediated suppression of natural immune mechanisms and metastatic enhancement

Surgical stress mediated suppression of natural killer cell cytotoxicity and metastatic enhancement

Surgical stress mediated suppression of natural killer cell cytotoxicity and metastatic enhancement

Surgical stress generation of suppressor cells which impair natural killer cell cytotoxicity

Percoll gradient isolation of surgical stress generated NK suppressor cells

Surgical stress impairment of murine natural killer cell cytotoxicity

Characterization of surgical-stress generated NK suppressor cells

Venous access systems for chemotherapy

How to write a National Cancer Institute K08 clinician-investigator training grant

Surgical stress impairs cytotoxic lysis kinetics (V Max) of murine natural killer cells

Surgical stress impairment of natural immunity: Preclinical and Clinical Studies

How to write a training grant application

Reversal of tumor-induced suppression of natural killer cell cytotoxicity does not prevent metastases

Identification of human peripheral blood lymphocytes (PBL) responsible for long-term IL-2 dependent antitumor cytotoxicity

Computer-assisted models of NK cell cytotoxicity (NKCC) for lytic unit calculations

Dissociation of growth and antitumor activity of IL-2 activated human blood lymphocytes: isolation of the subset with highest cytotoxic activity

Central venous access for patients with inaccessible superior vena cavae

Totally implanted versus percutaneous central venous access system in cancer patients: a case-control analysis of durability and cost

Splenic natural killer cell cytotoxicity (NKCC) can be augmented in patients with leukemia

Mechanism of surgical stress impairment of human perioperative natural killer cell cytotoxicity

Conflict of interest in academic surgery

Surgical stress impairment of human perioperative natural immunity

Increased activity and expression of pp60cc-src in liver metastases of human colon tumors

Current concepts in the local treatment of sarcomas

Islet cell carcinoma of the pancreas: preoperative (neoadjuvant) chemoembolization - infusion in patients with concomitant primary lesions and liver metastases

Preoperative radiotherapy and limb-sparing surgery for soft tissue sarcomas: Influence of margins on outcome

Surgical stress impairs natural killer cell calcium-dependent delivery of lethal hit to tumor

Multidisciplinary therapy of sarcomas

Multidisciplinary therapy of sarcomas

The effects of surgery on immune suppression

Impact of a short course in ethics of research on T32 surgical investigator trainees

Sarcoma of the breast: prognostic factors and their implications for therapy

Human fibroblasts produce paracrine motility factor(s) for human sarcoma cells

Management of retroperitoneal sarcomas

Growth enhancement of human soft tissue sarcoma cell lines by epidermal growth factor (EGF) and insulin-like growth factors-1 (lGF-1)

Contemporary management of soft tissue sarcoma

New developments in connective tissue oncology

Current surgical therapy of abdominal sarcomas

New perspectives in soft tissue sarcoma

Current trends in the management of sarcoma

A general surgeon’s look at presacral masses

Inhibition of platelet derived growth factor receptor (PDGFr) signal transduction results in decreased proliferation of human soft tissue sarcoma

Identification, purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells

Reintroduction of wild type (wt) p53 inhibits soft tissue sarcoma

Sarcoma metastasis: Clonal expansion of p53 mutated primary tumor cells

Recent experience with 100 desmoid tumors: Analysis of prognostic factors influencing outcome

The natural history of clear cell sarcoma

New frontiers in breast cancer: the surgical oncology perspective

Contemporary approaches to soft tissue sarcoma

Increased tumor radiosensitivity in human sarcoma cells transduced with wild-type p53

International oncology education

New surgical approaches to soft tissue sarcomas

Wild type p53 transfection inhibits soft tissue sarcoma

Reintroduction of wild type p53 enhances sarcoma chemosensitivity

Quality assurance of cancer therapy: surgery

Soft tissue sarcoma: Clinical implications of new biology, Postgraduate Course

International surgical oncology education; the American College of Surgeons/UICC Cancer Management Course Program

Advances in brief: molecular therapeutics in soft tissue sarcoma

Wild type p53 transfection inhibits soft tissue sarcoma growth and enhances chemosensitivity

Grantsmanship: How to achieve success

Contemporary management of retroperitoneal tumors

Contemporary management of extremity soft tissue sarcoma

Therapeutic issues in sarcomas of the retroperitoneum

The role of splenectomy in leukemia

Molecular perspectives in soft tissue sarcoma

New directions in carcinoma of the breast

Multimodality treatment of gastric carcinoma

Contemporary management of soft tissue sarcoma

Molecular approaches to soft tissue sarcoma

High risk soft tissue sarcoma: An overview

Gene therapy in malignancies

Role of multi-modality therapy in management of soft tissue sarcomas of the extremity

International surgical oncology education; the American College of Surgeons/UICC Cancer Management Course Program

Molecular approaches to soft tissue sarcoma

Current status of cooperative group trials in sarcoma

Contemporary management of soft tissue sarcoma

Quality assurance in cancer surgery

Current management of soft tissue sarcoma

Contemporary management of soft tissue sarcoma

Principles of molecular biology and gene therapy

New directions in breast cancer

Contemporary management of soft tissue sarcoma

Value of the sentinel lymph node biopsy for the detection of micrometastases

Contemporary management of soft tissue sarcoma

Contemporary and future therapeutics in soft tissue sarcoma

Molecular approaches to soft tissue sarcoma

Retroperitoneal sarcomas and Sentinel node biopsy in melanoma

Wild-type p53 down-regulates vascular endothelial growth factor expression in human leiomyosarcoma and synoviosarcoma cells

New molecular approaches to soft tissue sarcoma. Symposium: Genes, proteins and therapy in soft tissue sarcomas

Contemporary management of soft tissue sarcoma

Soft tissue sarcoma diagnosis, treatment, and research progress

New molecular perspectives in soft tissue sarcoma

Increasing ethnic diversity among academic oncology specialists and scientists

The value and technique of sentinel node biopsy

Limb sarcomas in adults: The experience of M.D. Anderson Cancer Center

The promises of regional therapies in controlling disease in retroperitoneal sarcomas

Neoadjuvant therapy for cancer

Soft tissue sarcoma

Contemporary management of soft tissue cancer

Challenges for surgical leaders

Adjuvant chemotherapy for high grade extremity sarcoma – beneficial vs useless

What’s new in Houston surgery

Standardization of sarcoma pathology reporting: What the surgeon needs

Multidisciplinary management of soft tissue sarcoma

Management of soft tissue sarcomas

Surgery and laboratory investigations for soft tissue sarcoma

New directions in soft tissue sarcoma

Contemporary management of soft tissue sarcoma

Biologic and therapeutic implications of tumor local recurrence

The role of the surgical oncologist

Sarcoma update: State-of-the-art therapy and future directions

Laboratory research findings in soft tissue sarcoma

Multidisciplinary cancer treatment: Expanding opportunities

Contemporary management of soft tissue sarcoma

Sarcoma

Principles of sarcoma surgery

Keynote address: new approaches in soft tissue sarcoma

Contemporary management of retroperitoneal sarcoma

The future of surgical oncology training: The U.S. perspective

Sarcoma surgery: Lesson learned

Contemporary management of soft tissue sarcoma

Staging soft tissue sarcoma: State of the art and opportunities for the future

Evolution de la classification TNM

Clinical dilemmas in surgical oncology

Value-based health care delivery

Limits of resectability in sarcoma

Management of complex retroperitoneal sarcoma

Contemporary issues in soft tissue sarcoma management

Lessons learned, unlearned, and relearned

Molecular staging and multidisciplinary management of soft tissue sarcomas

Sarcoma basis of metastasis through the vascular system

Oncology surgery in the management of multidisciplinary cancer: history and prospects

Current state and management of the multidisciplinary soft tissue sarcoma and of the extremities

Controversies in the management of retroperitoneal sarcoma

Contemporary issues in sarcoma

Contemporary approaches to sarcoma of the retroperitoneum and abdomen

Plenary session: The role of surgical oncology in multidisciplinary cancer care

New translational research perspectives in soft tissue sarcoma

Contemporary multimodality approaches to localized malignancy: a surgical oncologist’s perspective

Establishing an experimental platform for translational liposarcoma research studies

New technologies in cancer surgery

Board certification in surgical oncology; opportunities and challenges

Clinical problems in oncology: Surgery for soft tissue sarcomas

Surgery for sarcoma metastases

Onco-anesthesiology; An emerging medical specialty whose time has come?

Options in management of retroperitoneal sarcoma

Meet the Professor Session: A multidisciplinary approach to integrating local therapies with systemic approach in soft tissue sarcomas

Surgery in extremity soft tissue sarcoma

Sarcoma tumor board

Great Debates; Extended resection for retroperitoneal STS improves survival

Fibromatoses/desmoid tumors: the state of art and future perspectives

Contemporary management of Pelvic Sarcoma; Internal Hemipelvectomy

Extended surgery for retroperitoneal liposarcoma

Contemporary Issues in Soft Tissue Sarcoma Multidisciplinary Care, State of the Art Lecture

Recent approaches and results in sarcomas

Personalising local treatment of STS, in brief.

Setting the Stage: Natural History, Staging and Prognostic Factors

Difficult cases in sarcoma

Emerging multidisciplinary approaches for the management of gastrointestinal stromal tumors

[Retroperitoneal liposarcoma].

SURGICAL STRESS IMPAIRS MURINE NATURAL-KILLER CELL CYTO-TOXICITY (NKCC) - MULTIPLE SUPPRESSOR CELLS

ROLE OF ERYTHROBLAST IN MECHANISM OF SURGICAL STRESS IMPAIRMENT OF MURINE NATURAL-KILLER CELL CYTO-TOXICITY (NKCC)

SURGICAL STRESS IMPAIRMENT OF MURINE NATURAL-KILLER-CELL CYTOTOXICITY

RECOMBINANT IL-2 (RIL-2) INHIBITS SURGICAL-STRESS GENERATED NK SUPPRESSOR CELLS

 

Technical Reports

Role of surgery in the management of cancer pain, clinical practice guideline for the management of cancer pain

 

Unpublished Works

A clinicopathologic portrait of sporadic peripheral schwannomas

High throughout Raman spectral imaging complements optical coherence tomography for tumor boundary detection

IRF8 expressed in T cells and tumor cells regulates GM-CSF expression to control myelopoiesis and myeloid-derived supressor cell differentiation

Accuracy of preoperative percutaneous biospsy for the diagnosis of retroperitoneal liposarcoma subtypes

Vascular Leiomyosarcoma: Clinical observation and molecular variables

A novel and potent inhibitor of the MDM2:p53 axis for the treatment of dedifferentiated liposarcoma