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Research

Sashwati Roy, Ph.D.


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-7657

Email: roy.63@osu.edu

 

Current OSU Appointment

Associate Professor, General Surgery

 

Advising Narrative

Denman - Biological Sciences 2006Co-authored a paper:Roy, S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen CK. Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells. DNA Cell Biol. 2005 Apr;24(4):244-55.
Denman Undergraduate Research Forum, 4th Place Winner in 2005Awarded the Denman recognition for outstanding presentation of his scientific research. Viren also published six international peer-reviewed publications including two as first author: Patel V, Khanna S, Roy S, Ezziddin O, Sen CK. Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal. Free Radic Res. 2006 Jul;40(7):763-71. Khosla P, Patel V, Whinter JM, Khanna S, Rakhkovskaya M, Roy S, Sen CK. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Antioxid Redox Signal. 2006 May-Jun;8(5-6):1059-68. Bagchi D, Roy S, Patel V, He G, Khanna S, Ojha N, Phillips C, Ghosh S, Bagchi M, Sen CK. Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries. Mol Cell Biochem. 2006 Jan;281(1-2):197-209. Khanna S, Patel V, Rink C, Roy S, Sen CK. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic Biol Med. 2005 Nov 15;39(10):1310-9. Patel V, Chivukula IV, Roy S, Khanna S, He G, Ojha N, Mehrotra A, Dias LM, Hunt TK, Sen CK. Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress. Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1377-87.
Her thesis work became part of a larger project that was published: Patel V, Chivukula IV, Roy S, Khanna S, He G, Ojha N, Mehrotra A, Dias LM, Hunt TK, Sen CK. Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress. Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1377-87.
Biological Sciences
Biological Sciences

Academic Advising

2009 Amitava Das, The Ohio State University. Graduated 0.
2013 Sarah Chaney, The Ohio State University. Graduated 0.
2016 Sriteja Dixit, The Ohio State University. Graduated 0.
2003 - 2007 Navdeep Ojha, The Ohio State University. Graduated 2007.
2007 Trenton Rink, The Ohio State University. Graduated 0.
2004 - 2008 Cameron Rink, The Ohio State University. Graduated 2008.
2004 - 2008 Cameron Rink, The Ohio State University. Graduated 2008.
2008 Daniel Pugmire, The Ohio State University. Graduated 0.
2007 - 2010 Laura Kearns, The Ohio State University. Graduated 0.
2007 - 2010 Han-a Park, The Ohio State University. Graduated 2010.
2010 Courtney Jabolinsky, The Ohio State University. Graduated 0.
2008 - 2014 Jaideep Banerjee, The Ohio State University. Graduated 2014.
2014 Ravi Ramacharmdran, The Ohio State University. Graduated 0.
2015 Tirth Patel, The Ohio State University. Graduated 0.
 

Chapters in Books

Biochemical Monitoring of the Aquatic Environment using Macrophytes

Bioconcentration and metabolism of organic pollutants in aquatic plants

Biochemical monitoring of the aquatic environment: Possibilities and limitations

Peroxidase activity in aquatic plants as a marker of aquatic pollution

Ortho- and para- hydroxylation of pentachlorophenol in aquatic plants: possible involvement of cytochrome P-450

Biotrasformation and antioxidant enzymes in aquatic organisms as bioindicators of pollution

Bioindicators of Environmental Health

Use of aquatic plants in ecotoxicology monitoring of organic pollutants: bioconcentration and biochemical responses

Macrophyte enzymes as indicators of aquatic pollution

Therapeutic potential of alpha-lipoic acid: molecular aspects

Assessment of pollution using biotransformation enzymes in fish as biomarkers

Fish and plant as experimental organisms: aquatic toxicology as an example

Integrative approach to aquatic environment biomonitoring

Therapeutic potential of the antioxidant and redox properties of alpha-lipoic acid

Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription.

Antioxidant properties and regulation of gene expression

Oxidants and Antioxidants in glutamate-induced cytotoxicity

Alpha-lipoic acid: cell regulatory function and potential implications

Redox Regulation of Cell Adhesion Processes

Wound healing

Down-regulation of agonist-induced nitric oxide synthesis and cell-cell adhesion by Ginkgo biloba extract EGb 761: therapeutic efficacy in circulatory disorders

Determination of nuclear factor-kB activity

Resolution of inflammation

Role of Edible Berry Anthocyanins in Angiogenesis

Wound Inflammation: From Initiation to Resolution

Disorder of localized inflammation in wound healing: a system's perspective

Micromanaging Inflammation and Tissue Repair

Wound Inflammation: Emerging role of miRNA in MicroRNAs and other non-coding RNAs in inflammation

Genomics as a Tool to Characterize Anti-inflammatory Nutraceuticals

Proteomics and Nutrition Research

Exercise induced oxidative stress and antioxidant nutrient

 

Conferences

Activation of oxygen-sensitive gene expression following ischemia-reperfusion: Characterization of perceived hyperoxia in the heart

Perceived hyperoxia: Oxygen sensing in reoxygenated cardiac fibroblasts

Perceived hyperoxia in the reoxygenated heart: Oxygen-sensitive signaling for cell cycle arrest and differentiation of cardiac fibroblasts

Impaired clearance of apoptotic cells in diabetic wounds

Fra2 mediates oxygen-induced TGFbeta-1 mRNA expression in adult cardiac fibroblasts: Significance in myocardial fibrosis following ischemia-reperfusion injury

 

Edited Books

7th International Bioindicators Symposium and Workshop on Environmental Health

Chronic Inflammation: Molecular Pathophysiology, Nutrition and Therapteutic Interventions

 

Editorial Activities

present SOCIETY OF ADVANCED WOUND CARE (SAWC)
present SOCIETY FOR FREE RADICAL BIOLOGY AND MEDICINE
present AMERICAN HEART ASSOCIATION (AHA)
present Cytokine
present WOUND HEALING SOCIETY
present AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY (ASBMB)
2008 Plos one
2008 Journal of Leukocyte Biology
2008 Circulation
2008 BMC genomics
2008 Journal of Investigative Dermatology
2014 Physiological Genomics
2014 Journal American College of Nutrition
2014 Advances in Wound Care
 

Journal Articles

"Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts." CARDIOVASCULAR RESEARCH. Vol. 87, no. 4. (September 2010.): -.

"Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 182, no. 12. (December 2010.): -.

"Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction." PLOS ONE. Vol. 8, no. 6. (June 2013.): -.

 

Inventions and Patents

Lipoic acid analogues

 

Presentations

Physiology, Molecular Mechanisms and Prevention

Presentation

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Presenation

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Presenation

Molecular and Biological Mechanisms of Antioxidant Action

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Presentation

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presentation

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Microarray Data Analysis: from Pattern to Pathways

DNA Microarray Technology

Reoxygenation-Induced Myocardial Remodeling

Reoxygenation-Induced Myocardial Remodeling

Molecular Determinants of Wound Healing

Significance of Dead Cell Clearance in Wound Healing

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Tocotrienol: The Natural Vitamin E against Stroke Related Neurodegeneration

c-Src Signals for Neurodegeneration:Protective Effects of Alpha-Tocotrienol

What is Efferocytosis and why do we need to know?

Dead Cell Clearance: Significance in Tissue Repair

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Dysregulated apoptotic cell clearance in diabetic wounds

Surgical Infections & Healing Surgical Wounds

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a

Annual meeting

Cellular Debridement and Wound Inflammation

Scientist seminar

MicroRNA Discussion

a

TRENDS: Traditional and Progress

Presentation

Human Nutrition

Seminar

Scientific Sessions

Podium presentation

Meeting

Podium presentation

Tocotrienols

Workshop

Wound Care

Podium presentation

Scientific Sessions

Wound Healing

Joint Meeting

Redox Biology and Micronutrients: from signaling translation and back

Lecture

Biochemitry Seminar

Heart Rhythym

Endocrinology

Society for Free Radial Research

Diabetes

Anesthesia Research

Regenerative Wound Care

Health

Organizing Committee

Advanced Wound Care and Wound Healing Society

Annual Retreat

Workshop

Wound Healing and Tissue Repair

Experimental Biology

Strategic Meeting

Annual Meeting

Wound Healing

Wound Care

Impact on Health Wellness, Environment and Economics

H3C

Chronic Wound Care

Wound Care and Wound Healing

Shock

Inflammation and Health

Impact on Health, Wellness, Environment and Economics

 

Professional Activities

2006 - present First Annual Research Day poster competition.
2006 - present OSUMC Research day.
2006 - present DHLRI Research Retreat.
2007 - present Interview. Department of Human Nutrition for faculty.
2007 - present OSUMC Research day.
2007 - present Oral Session. DHLRI Research Retreat.
2007 - present Director of Trauma Interview. Dept of Surgery, Div. of Critical Care, Trauma and Burns.
2007 - present DHLRI Research Retreat.
2007 - present DHLRI Research Retreat.
2008 - present OSUMC Research day.
2008 - present Denman Undergraduate research Forum.
2009 - present Research Day. Department of Surgery.
2009 - present Denman Undergraduate Research Forum.