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Research

Zhiwei Hu, MD, PhD


410 W 12th Ave
Wiseman Hall 3rd floor (CCC)
Columbus, OH 43210

Phone: (614) 685-4606

Email: hu.788@osu.edu

 

Current OSU Appointment

Research Associate Professor, Surgical Oncology

 

Master/Graduate Advising

I have been advising/co-advising master and doctoral graduate students since I joined OSU faculty in 2012.

Undergraduate, Graduate, and Professional Courses Taught

I have been participating in teaching undergraduate and graduate courses, including Research for Credit courses at Yale Departments of Molecular Biophysics and Biochemistry and of OBGYN during my tenure at Yale University, and Biochem 4998 (2014) and BSGP7900 (starting September 2015) at the Ohio State University College of Medicine, Wexner Medical Center and the OSU James Comprehensive Cancer Center.

Research Interest

Tumor Immunology, Tumor Angiogenesis, Targeted Immunotherapy, Targeted Photodynamic Therapy, Gene Therapy, Translational Cancer Research, Antibody, Immunoconjugates, Natural Killer Cells, Cancer Stem Cells

Academic Advising

2013 Shengjia Gao, The Ohio State University. Graduated 2015.
2013 Amanda Harper, The Ohio State University. Graduated 0.
2015 Meghan Flannery, The Ohio State University. Graduated 0. Neovascular-targeted microbubbles for ultrasound diagnosis of cancer
2015 Elizabeth McMichael, The Ohio State University. Graduated 0.
2005 N/A , Yale University. Graduated 0. Icon-targeted photodynamic therapy for cancer.
2005 N/A , Yale University. Graduated 0. Icon-targeted photodynamic therapy for cancer, tumor angiogenesis, and Icon protein purification and detection.
2005 N/A , Yale University. Graduated 0. Icon-targeted photodynamic therapy for cancer, tumor angiogenesis, and Icon protein purification and detection.
2005 N/A , Yale University. Graduated 0. Icon-targeted photodynamic therapy for cancer, tumor angiogenesis, and Icon protein purification and detection.
2006 N/A , Yale University. Graduated 0. Icon-mediated therapies and tumor angiogenesis.
2006 N/A , Yale University. Graduated 0. Icon-mediated therapies and tumor angiogenesis.
2007 N/A , Yale University. Graduated 0. The role of tissue factor on tumor angiogenesis.
2013 Zi Li, The Ohio State University. Graduated 0.
2014 - 2015 Meghan Flannery, The Ohio State University. Graduated 2015. An Investigation of a Novel NKG2D Ligand-Targeting Fusion Protein with Potential as a Cancer Immunotherapeutic Agent
2014 - 2015 Dr. Qikun, The Ohio State University. Graduated 2015.
 

Chapters in Books

Antigen-driven stimulation of B-lymphocytes in vitro

Factor VII-Targeted Photodynamic Therapy for Breast Cancer and Its Therapeutic Potential for Other Solid Cancers and Leukemia

 

Conferences

Therapeutic targeting of tissue factor on the neovascular endothelium with factor VII Icons

Tissue factor as a therapeutic and diagnostic target for the tumor neovasculature

A novel immunotherapy for endometrial adenocarcinoma targeting tissue factor overexpression

 

Degrees

1991 M.D., Jiangxi Medical College

1994 M.S., Jiangxi Medical College

1997 Ph.D., Hunan Medical University

 

Editorial Activities

2007 - present The International Journal of Cancer
2008 - present The Journal of Immunology
2010 - present Current Cancer Drug Targets
2010 - present Biologicals (Journal of the International Association for Biologicals)
2010 - 2012 The Journal of Analytical & Bioanalytical Techniques
2011 - present BMC Cancer
2011 - present The Journal of Solid Tumors
2011 - present The Journal of Solid Tumors
2011 - present Lung Cancer: Targets and Therapy
2011 - present International Journal of Nanomedicine
2011 - present HIV/AIDS: Research and Palliative Care
2011 - present Clinical Oncology and Cancer Research
2011 - present Breast Cancer: Targets and Therapy
2011 - present Breast Cancer Research and Treatment
2011 The Journal of Analytical & Bioanalytical Techniques
2012 - present The Open Journal of Immunology
2012 - present The Oncologist
2012 - present The Journal of Immune Based Therapy, Vaccines and Antimicrobials
2012 - present Photomedicine and Laser Surgery
2012 - present Advances in Breast Cancer Research
2012 - present Dataset Papers in Medicine
2012 - present The Open Journal of Apoptosis
2012 - present The Journal of Analytical & Bioanalytical Techniques
2012 - present The Journal of Immune Based Therapies, Vaccines and Antimicrobials
2012 - present The Journal of Cancer Research and Treatment
2013 - present Stomatology Journal
2013 - present PLOS One
2013 - present International Journal of Cancer Research and Diagnosis
2013 - present Open Journal of Immunology
2013 - present Journal of Immunotherapy Applications
2013 - present Journal of Leukemia
2013 - present The Journal of Oral Oncology
2013 - present British Journal of Medicine and Medical Research
2013 - present Enliven: Challenges in cancer
2014 - present Qatar National Research Fund, Doha, State of Qatar
2014 - present Final Performance Review-13-14 Cycle B for The Pennsylvania Department of Health, USA
2014 - present Enliven: Bio Analytical Techniques
2014 - present Journal of Vaccine and Immunotechnology
2014 - present MOJ Immunology
2015 - present Autoimmune and Infectious Diseases: Open Access
2015 - present Immune Research: Open Access
2015 - present Journal of Surgery: Open Access
2015 Immune Research: Open Access
2015 Journal of Surgery: Open Access
 

Honors

1986 - 1991 Annual Student’s Scholarship (First Class). Jiangxi Medical College.
1986 - 1991 Annual Honor Student. Jiangxi Medical College.
1995 - present The Excellent Thesis Award at the 6th Annual Meeting on Cancer and the 7th Annual Meeting on Immunology. Chinese Association for Pathophysiology.
1996 - 1997 Fellowship. Dr. Xianzhi Su Education Foundation.
2002 - 2005 The C. G. Swebilius/Yale Cancer Center Translational Cancer Research Award. Yale Cancer Center.
2006 - 2008 The Susan G. Komen Award. Susan G. Komen for the Cure Foundation.
2015 - 2016 OSU CCTS L-Pilot Phase 1 Award. OSU CCTS.
2016 - 2017 Dr. Falk Catalyst Award. The Dr. Ralph and Marian Falk Medical Research Trust.
 

Journal Articles

 

Reference Works

April 2002 Zhiwei Hu, Jing Li, Alan Garen."Immunotherapy of human solid tumors mediated by a Tissue Factor:Factor VII complex" .
July 2003 Zhiwei Hu, Jing Li, Alan Garen."Targeting pathological neovasculature for immunotherapy of human tongue cancer in SCID mice: Role of natural killer cells" .
January 2004 Tezel TH, Sonmez K, Cruz JMC, Kapliappan S, Bora PS, Hu Z, Garen A and Kaplan HJ."Selective immunotherapy for choroidal neovascularization with intravitreal factor VII-Fc chimeric antibody (ICON)" . : E-Abstract 1859
August 2004 Fang Lu, Zhiwei Hu, Alan Garen, Ron Adelman."Targeted Photodynamic Therapy for Choroidal Neovascularization in a Laser-Induced Rat Model" .
January 2004 Sonmez K, Tezel TH, Kaliappan S, Cruz JMC, Bora PS, Hu Z, Garen A and Kaplan HJ."Selective targeting of choroidal neovascularization (CNV) with factor VII-Fc chimeric antibody (ICON): comparison with anti-von Willebrand antibody" . : E-Abstract 1860
February 2004 Graciela Krikun, Zhiwei Hu, Pei Hui, William Konigsberg, Charles Lockwood, Alan Garen."A novel immunotherapy for endometrial adenocarcinoma targeting tissue factor overexpression" . : 180A-181A 320 Suppl. S
June 2005 Palumbo JS, Massari JV, La Jeunesse CM, Flick MJ, Hu Z, Talmage KE, Degen JL."Interplay between tumor cell-associated and circulating coagulation factors in establishing metastatic potential" . : 202A-203A 686 Part 1
April 2005 Zhiwei Hu and Alan Garen."Icon-Targeted Immunotherapy and Photodynamic Therapy for Breast Cancer." .
June 2005 Zhiwei Hu and Alan Garen."Targeting Neovasculature for Development of Icon-Mediated Immunotherapy and Photodynamic Therapy of Pancreatic Cancer" .
March 2007 Ron Adelman, Fang Lu, Zhiwei Hu, J Sinard, Alan Garen."Histopathology of Icon-targeted photodynamic therapy for treatment of choroidal neovascularization in a laser-induced rat model" .
April 2008 Zhiwei Hu, Benqiang Rao, Shimin Chen, Alan Garen."Targeting tissue factor for photodynamic therapy of breast cancer" .
December 2016 Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth McMichael, Lianbo Yu, Bhuvana Ramaswamy, Cheryl A. London, Tian Xu and William E. Carson III."Late-breaking abstract for poster presentation at the SITC 31st Annual Meeting on November 11-13, 2016 in National Harbor, MD" . : 232-233
January 2017 ."" .
Zhiwei Hu*, Elizabeth McMichael, Amanda Harper, Cheryl A. London and William E. Carson III."Tissue Factor-Targeted Immunotherapy of Melanoma and Triple Negative Breast Cancer Using A Second Generation ICON" .

Softwares

February 1998 Hu,Z.W. and Sun,Q.B."Homo sapiens clone EL6D immunoglobulin heavy chain variable region gene, partial cds" GenBank
February 1998 Hu,Z.W. and Sun,Q.B."Homo sapiens clone EL17 immunoglobulin kappa light chain variable region gene, partial cds" GenBank
February 1998 Hu,Z.W. and Sun,Q.B."Homo sapiens clone EL5D immunoglobulin kappa light chain variable region gene, partial cds" GenBank
February 1998 Hu,Z.W. and Sun,Q.B.."Homo sapiens clone CA12 immunoglobulin heavy chain variable region gene, partial cds" GenBank
August 2000 Hu,Z. and Garen,A.."Synthetic construct mutated mouse factor VII molecule immunoconjugate mRNA, complete cds." GenBank
August 2000 Hu,Z. and Garen,A.."Synthetic construct anti-human melanoma single-chain variable fragment antibody G71-1 immunoconjugate mRNA, complete cds." GenBank
May 2000 Hu,Z. and Garen,A."Homo sapiens factor VII active site mutant immunoconjugate mRNA, complete cds" GenBank

Inventions and Patents

Neovascular-targeted immunoconjugates

Neovascular-targeted immunoconjugates

Neovascular-targeted immunoconjugates

Neovascular-Targeted Immunoconjugates

Neovascular-Targeted Immunoconjugates

Factor VII conjugates for selectively treating neovascularization disorders

Factor VII conjugates for selectively treating neovascularization disorders

Targeted Immunotherapy of Melanoma with Second Generation ICON

NKG2D-Fc as a Novel Therapeutic Agent for NKG2D Ligand-Targeting Immunotherapy for the Treatment of Cancer and Viral Infections

 

Presentations

Immunotherapy of human solid tumors mediated by a Tissue Factor:Factor VII complex

Targeting pathological neovasculature for immunotherapy of human tongue cancer in SCID mice: Role of natural killer cells

Targeted Photodynamic Therapy for Choroidal Neovascularization in a Laser-Induced Rat Model

Icon-Targeted Immunotherapy and Photodynamic Therapy for Breast Cancer

Targeting Neovasculature for Development of Icon-Mediated Immunotherapy and Photodynamic Therapy of Pancreatic Cancer

Histopathology of Icon-targeted photodynamic therapy for treatment of choroidal neovascularization in a laser-induced rat model

Targeting tissue factor for photodynamic therapy of breast cancer

Selective and effective targeting of tumor blood vessels and tumor cells using a novel factor VII-targeted photodynamic therapy

Simultaneously Targeting Tumor Blood Vessels and Tumor Cells for Immunotherapy and Photodynamic Therapy of Cancer

Tissue factor-targeted photodynamic therapy for dual-targeting of tumor cells and tumor neovasculature

Tissue factor as a novel therapeutic target for cancer immunotherapy and photodynamic therapy

Neovascular-targeting immunotherapy for cancer and other angiogenesis-dependent diseases

Environmental chemicals in tumor angiogenesis

Tissue factor: a common yet specific target for tumor cells and tumor neovasculature in the development of cancer immunotherapy and photodynamic therapy

Utilizing a Factor VII-IgG1 Fc Fusion Protein and Interleukin-15 To Promote Natural Killer Cell Activity Against Metastatic Melanoma

Large scale production, purification and characterization of recombinant proteins in Chinese Hamster Ovary cells. Poster at the 2014 International Scholar Research Exposition

Targeting tissue factor for photodynamic therapy of cancer

Tissue factor-targeted cancer therapeutics

Environmental chemicals in tumor angiogenesis

 

Professional Activities

present Peer Reviewer. Shanghai Jiao Tong University.
present Grant Reviewer. Qatar National Research Fund.
present Grant Reviewer. The Pennsylvania Department of Health.
present Grant Reviewer. Medical Research Council.
present Grant Reviewer. Ministry of Science and Technology of the People’s Republic of China.
present Grant Reviewer. Oak Ridge Associated Universities (ORAU). Oak Ridge, TN.
present Grant Reviewer. The Pennsylvania Department of Health.
present Grant Reviewer. The Pennsylvania Department of Health.
present Grant Reviewer. Qatar National Research Fund.
present Supervisor. Yale University.
present Team Leader and Lead Author. Getting to Know Cancer.
2006 Mentor. Summer Undergraduate Research Fellowship (SURF) Program, Yale Graduate School.
2007 - 2008 Mentor. Bristol-Myers Squibb Summer Science Internship Program, Yale Cancer Center.
2005 - 2009 Scientific Advisor/Consultant. Scientific Advisor/Consultant. Atlanta, GA.
2008 - 2011 Mentor. Discovery to Cure Internship Program, Yale University.
2011 - 2012 Vice President. The Chinese Association for Science and Technology in Connecticut (CAST-CT),.