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Research


We have placed a renewed emphasis on our academic tradition at Ohio State. Faculty in our Division have interests in clinical outcomes research, health care policy/administration/financing, basic and translational stroke mechanisms, and stem cell therapy for limb ischemia. Our research coordinator maintains a prospective database of all procedures for use in retrospective reviews and outcomes studies.
 

Cameron Rink, PhD, has expanded our scientific focus to include the basic mechanisms of stroke infarct evolution and exciting translational applications of oxygen and nutrient therapy to treat stroke. Dr. Rink’s laboratory is interested in understanding the specific role of molecular oxygen in stroke pathology. Fundamental to this pursuit is the mechanistic understanding of how oxygen serves brain tissue as both a substrate for life-sustaining glucose metabolism, and in a setting of cerebral ischemia as a catalyst for pathological oxidative stress. In pursuing this objective, we have established several novel in vitro and in vivo models to study hypoxic-ischemic cell death, reperfusion injury biology, and by correcting the hypoxia component of stroke, the unique contribution of oxygen to ischemic brain injury. Research efforts span basic to translational science, with an emphasis on cutting-edge scientific tools such as electron paramagnetic resonance imaging for non-invasive oxymetry, and laser capture microdissection for cell and site specific resolution of stroke biology.

Significance of Brain Tissue Oxygenation and the Arachidonic Acid Cascade in Stroke.

Oxygen-sensitive outcomes and gene expression in acute ischemic stroke.

Jean Starr, M.D. has a research interest in endovascular surgery and clinical outcomes studies, in addition to serving as the local Principal Investigator, several multicenter trials and registries. Her current projects include a study of the financial impact of ultrasound-accelerated thrombolysis versus standard thrombolysis, long term complications from IVC Filters, and the effect of obesity on surgical site infections. She also leads local and regional advocacy efforts for women in surgery. Dr. Starr is also Principal Investigator of a Boston Scientific trial of the EPIC Nitinol stent system in the treatment of atherosclerotic lesions in the iliac arteries to determine whether its use for primary stenting shows acceptable performance at 9 months.

Bhagwan Satiani, MD, MBA, has written and presented extensively in the areas of the vascular diseases, non-invasive testing, business of medicine, workforce issues, health care policy, appropriateness of non-invasive testing with national cost implications and administration as well as workforce shortage and faculty retention. He has become an acknowledged regional and national expert in these areas. He is also Director of the Faculty Leadership Institute at the Wexner Medical Center  at The Ohio State University. In addition, he is the Director of our ICAL-accredited vascular laboratory and Co-Course Director of our Annual Vascular Noninvasive Testing Symposium, and is involved in research in the vascular lab with carotid intima-media thickness measurement and brachial artery reactivity testing.

Michael Go, MD, is active in clinical outcomes research focusing on treatment of non-healing lower extremity wounds and critical limb ischemia and continues to publish in the area of vascular non-invasive ultrasound testing.  He participates as a Co-Investigator in an NIH-funded R01 project investigating the role of magnetic resonance elastography in the diagnosis and management of abdominal aortic aneurysms and also collaborates with The Ohio State University Mathematical Biosciences Institute, developing a serum biomarker based mathematical model to predict aneurysm growth.  He is experienced in techniques of carotid intima media thickness measurement and brachial artery reactivity testing, providing these services through the Ross Heart Hospital Vascular Lab as a core resource for researchers throughout the OSU campus and for several multicenter trials.

Hosam El Sayed, MD, PhD has research interests in outcome clinical research, complex aortic endograft therapy for thoracic and abdominal aortic disease, endovascular lower extremity revascularization, evaluation and adoption of new technologies and therapies in vascular surgery.

Mounir Haurani, MD has research interests in thoracic, abdominal and peripheral aneurysms, carotid disease, venous obstructive disease, peripheral vascular disease, complex endovascular revascularization, IVC filter retrieval and placement, clinical outcomes reactive oxygen species and neointimal hyperplasia.

Led by Drs. Starr and Patrick Vaccaro, MD, we have consistently enrolled high numbers of patients in multicenter post-marketing registries and Phase II and III trials. Currently, we are actively enrolling or completing follow-up in the following trials: https://osuwmcdigital.osu.edu/sitetool/sites/surgeryvascular2public/documents/ResearchUpdate.pdf